concept

WNT SIGNALING

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about WNT SIGNALING: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

535Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	WNT SIGNALING
Key Genes/Proteins	AHR, AKT, ALZHEIMER, AMPK, AMYLOID, AMYLOID-BETA
Related Diseases	AGING, ALS, Alzheimer'S Disease, ALZHEIMER'S DISEASE, AMYOTROPHIC LATERAL SCLEROSIS

Pathway Diagram

graph TD
    WNT_SIGNALING["WNT SIGNALING"]
    WNT_SIGNALING -->|"dysregulated_in"| Alzheimer_s_disease["Alzheimer's disease"]
    WNT_SIGNALING -->|"activates"| MYC["MYC"]
    WIF1["WIF1"] -->|"inhibits"| WNT_SIGNALING
    MYC -->|"regulates"| WNT_SIGNALING
    SYNAPSE["SYNAPSE"] -->|"regulates"| WNT_SIGNALING
    SNCA["SNCA"] -->|"regulates"| WNT_SIGNALING
    AUTOPHAGY["AUTOPHAGY"] -->|"activates"| WNT_SIGNALING
    SQSTM1["SQSTM1"] -->|"activates"| WNT_SIGNALING
    BECN1["BECN1"] -->|"activates"| WNT_SIGNALING

Outgoing (86)

Target	Relation	Type	Str
Alzheimer's disease	dysregulated_in	disease	0.90
HIF1A	activates	gene	0.90
Astrocyte-Synapse Contact	inhibits	process	0.88
Prostate Cancer	associated_with	disease	0.80
MYC	activates	gene	0.80
tau phosphorylation	mediates	process	0.70
astrocytes	active_in	cell_type	0.70
DNMT3A	regulates	gene	0.70
neurons	active_in	cell_type	0.70
PSD95	inhibits	gene	0.70
NEURAL STEM CELLS	activates	cell_type	0.70
NEUROGENESIS	causes	phenotype	0.65
APOPTOSIS	activates	phenotype	0.65
WNT3A	activates	gene	0.65
AUTOPHAGY	regulates	phenotype	0.65
MITOCHONDRIAL DYSFUNCTION	degrades	phenotype	0.65
NEURONS	regulates	cell_type	0.65
OLIGODENDROCYTES	regulates	cell_type	0.65
NEURONS	activates	cell_type	0.65
NEURONS	inhibits	cell_type	0.65
NEURODEGENERATION	treats	disease	0.65
NEURODEGENERATION	activates	disease	0.65
NEURODEGENERATION	exacerbates	disease	0.65
MITOCHONDRIAL DYSFUNCTION	interacts_with	phenotype	0.65
APP	inhibits	gene	0.65
VEGFA	associated_with	gene	0.65
amyloid aggregation	mediates	process	0.60
synaptic plasticity	crosstalk_with	pathway	0.60
STEM CELLS	associated_with	cell_type	0.60
unfolded protein response	crosstalk_with	pathway	0.60
oligodendrocytes	active_in	cell_type	0.60
microglia	active_in	cell_type	0.60
neural stem cells	active_in	cell_type	0.60
temporal lobe	active_in	brain_region	0.60
WNT1	expressed_in	gene	0.55
NEUROGENESIS	participates_in	phenotype	0.55
ALZHEIMER'S DISEASE	implicated_in	disease	0.55
NEURODEGENERATION	implicated_in	disease	0.55
NEUROGENESIS	implicated_in	phenotype	0.55
DENTATE GYRUS	associated_with	brain_region	0.50
NEURONS	associated_with	cell_type	0.50
DNMT3A	associated_with	gene	0.50
GSK3B	associated_with	gene	0.50
TEMPORAL LOBE	associated_with	concept	0.50
BDNF	associated_with	gene	0.50
LITHIUM	associated_with	drug	0.50
APP	associated_with	gene	0.50
PSD95	associated_with	gene	0.50
AUTOPHAGY	associated_with	phenotype	0.50
PD-L1	inhibits	concept	0.50

Incoming (449)

Source	Relation	Type	Str
PI3K-AKT-mTOR Pathway	interacts_with	pathway	0.90
GSK3B	participates_in	gene	0.90
GSK3	participates_in	gene	0.90
WIF1	inhibits	protein	0.90
WIF1	regulates	gene	0.85
MYC	regulates	gene	0.85
BDNF	interacts_with	gene	0.80
TREM2	participates_in	gene	0.80
ERK	participates_in	gene	0.80
BACE1	participates_in	gene	0.80
WNT	participates_in	gene	0.80
MAPT	participates_in	gene	0.80
PI3K	participates_in	gene	0.80
MAPK1	participates_in	gene	0.80
APP	participates_in	gene	0.80
CLU	modulates	protein	0.75
SNCA	regulates	gene	0.75
MET	participates_in	gene	0.70
AKT	participates_in	gene	0.70
glioblastoma	involves	disease	0.70
Alzheimer's disease	involves	disease	0.70
CDK5	participates_in	gene	0.70
WIF1	participates_in	gene	0.70
TGF	participates_in	gene	0.70
ATG	participates_in	gene	0.70
BECN1	participates_in	gene	0.70
AMPK	participates_in	gene	0.70
MAP1LC3	participates_in	gene	0.70
LC3	participates_in	gene	0.70
RNA	participates_in	gene	0.70
MTOR	participates_in	gene	0.70
SQSTM1	participates_in	gene	0.70
PSEN1	participates_in	gene	0.70
MYC	participates_in	gene	0.70
LRP1	participates_in	gene	0.70
GAPDH	participates_in	gene	0.70
SIRT1	participates_in	gene	0.70
PKM2	participates_in	gene	0.70
MMP2	participates_in	gene	0.70
BDNF	activates	gene	0.70
REMYELINATION	regulates	phenotype	0.65
LACTATE	inhibits	phenotype	0.65
TH	targets	gene	0.65
TH	inhibits	gene	0.65
MICROGLIA	activates	cell_type	0.65
TDP-43	regulates	gene	0.65
CASP1	participates_in	gene	0.60
NIX	participates_in	gene	0.60
BNIP3L	participates_in	gene	0.60
CBP	participates_in	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Inhibitory Neuron-Selective WNT Signaling Restoration	0.554	neurodegeneration	Which cell types show the most significa

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning WNT SIGNALING in their description or question text

No additional research found