concept

INSOMNIA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about INSOMNIA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

61Connections

0Hypotheses

0Analyses

5Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	INSOMNIA
Key Genes/Proteins	circadian clock genes, OREXIN_A
Related Pathways	HPA_AXIS

Pathway Diagram

graph TD
    INSOMNIA["INSOMNIA"]
    INSOMNIA -->|"contributes to"| Neurodegeneration["Neurodegeneration"]
    INSOMNIA -->|"risk_factor_for"| Cardiovascular_Disease["Cardiovascular Disease"]
    CIRCADIAN_CLOCK_GENES["CIRCADIAN CLOCK GENES"] -->|"causes"| INSOMNIA
    Circadian_Clock_Genes["Circadian Clock Genes"] -->|"causes"| INSOMNIA
    Circadian_Misalignment["Circadian Misalignment"] -->|"contributes to"| INSOMNIA
    Melatonin["Melatonin"] -->|"treats"| INSOMNIA
    Genetic_Polymorphisms["Genetic Polymorphisms"] -->|"risk_factor_for"| INSOMNIA
    OREXIN_A["OREXIN-A"] -->|"regulates"| INSOMNIA
    Mitochondrial_Oxidative_Stress["Mitochondrial Oxidative Stress"] -->|"contributes to"| INSOMNIA

Outgoing (5)

Target	Relation	Type	Str
Metabolic Syndrome	risk_factor_for	disease	0.90
Mood Disorders	associated_with	disease	0.90
Neurodegeneration	contributes_to	process	0.85
Cardiovascular Disease	risk_factor_for	disease	0.85
Neurodegeneration	causes	process	0.80

Incoming (56)

Source	Relation	Type	Str
Circadian Clock Genes	causes	pathway	0.95
CIRCADIAN CLOCK GENES	causes	gene	0.95
Circadian Clock Genes	associated_with	pathway	0.95
vornorexant	treats	drug	0.90
sleep deprivation	causes	process	0.90
MTNR1A	therapeutic_target	gene	0.90
MTNR1B	therapeutic_target	gene	0.90
Circadian Misalignment	contributes_to	process	0.90
Covid-19	associated_with	disease	0.88
GABRA1	therapeutic_target	gene	0.85
HTR1A	therapeutic_target	gene	0.85
Pinghe Sleep Aromatherapy Product	treats	drug	0.85
Gabaergic Drugs	treats	drug	0.85
Neuroinflammation	associated_with	process	0.85
OREXIN-A	regulates	protein	0.85
Genetic Polymorphisms	risk_factor_for	biomarker	0.85
IL6	therapeutic_target	gene	0.85
HCRTR2 antagonist	treats	compound	0.85
AKT1	therapeutic_target	gene	0.85
TNF	therapeutic_target	gene	0.85
CASP3	therapeutic_target	gene	0.85
TP53	therapeutic_target	gene	0.85
VEGFA	therapeutic_target	gene	0.85
Mitochondrial Oxidative Stress	involved_in	process	0.80
Mitochondrial Oxidative Stress	associated_with	process	0.80
Mitochondrial Oxidative Stress	contributes_to	process	0.80
Serotonin	involved_in	compound	0.80
circadian clock genes	implicated_in	gene	0.80
neuroactive ligand-receptor interaction	involved_in	pathway	0.80
GABRB2	therapeutic_target	gene	0.80
PER	associated_with	gene	0.80
CRY	associated_with	gene	0.80
Covid-19	causes	disease	0.80
CLOCK	associated_with	gene	0.80
BMAL1	associated_with	gene	0.80
Neuroinflammation	contributes_to	process	0.80
Synaptic Plasticity	associated_with	process	0.80
linalool	treats	compound	0.75
D-limonene	treats	compound	0.75
calcium signaling pathway	involved_in	pathway	0.75
IL6	associated_with	gene	0.75
TNF	associated_with	gene	0.75
Luteolin	associated_with	compound	0.75
Linalool	associated_with	compound	0.75
D-Limonene	associated_with	compound	0.75
Healthcare Worker Status	risk_factor_for	phenotype	0.75
MSZRD	treats	drug	0.72
TNF	biomarker_for	gene	0.70
HIF-1 signaling pathway	involved_in	pathway	0.70
AKT1	implicated_in	gene	0.70

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity