concept

DIABETIC RETINOPATHY

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DIABETIC RETINOPATHY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

393Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

DIABETIC RETINOPATHY is a concept in neurodegeneration research. Key relationships include: therapeutic target, associated with, activates. Associated with Aging, Als, Atherosclerosis. Connected to 204 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	DIABETIC RETINOPATHY
Key Genes/Proteins	AGING, AKT, ALZHEIMER, ALZHEIMER'S DISEASE, AMYOTROPHIC LATERAL SCLEROSIS, AND
Related Diseases	Aging, Als, ALS, Alzheimer, Amyotrophic Lateral Sclerosis
Related Pathways	Angiogenesis, Apoptosis

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Diabetic Retinopathy

disease · 508 words

→

Pathway Diagram

graph TD
    DIABETIC_RETINOPATHY["DIABETIC RETINOPATHY"]
    DIABETIC_RETINOPATHY -->|"causes"| NEURODEGENERATION["NEURODEGENERATION"]
    DIABETIC_RETINOPATHY -->|"target for"| Neuropathy["Neuropathy"]
    DIABETIC_RETINOPATHY -->|"target for"| Als["Als"]
    DIABETIC_RETINOPATHY -->|"target for"| Cancer["Cancer"]
    DIABETIC_RETINOPATHY -->|"target for"| Ms["Ms"]
    DIABETIC_RETINOPATHY -.protects against.-> Inflammation["Inflammation"]
    DIABETIC_RETINOPATHY -.protects against.-> Diabetes["Diabetes"]
    DIABETIC_RETINOPATHY -.protects against.-> Neurodegeneration["Neurodegeneration"]
    DIABETIC_RETINOPATHY -.protects against.-> Neuroinflammation["Neuroinflammation"]
    DIABETES_MELLITUS["DIABETES MELLITUS"] -->|"causes"| DIABETIC_RETINOPATHY
    NF__B_pathway["NF-kappaB pathway"] -->|"activates"| DIABETIC_RETINOPATHY
    miRNA["miRNA"] -->|"regulates"| DIABETIC_RETINOPATHY
    JAK["JAK"] -->|"target for"| DIABETIC_RETINOPATHY
    VEGF["VEGF"] -->|"target for"| DIABETIC_RETINOPATHY
    HSP90AA1["HSP90AA1"] -->|"target for"| DIABETIC_RETINOPATHY
    CANCER["CANCER"] -->|"target for"| DIABETIC_RETINOPATHY
    APOPTOSIS["APOPTOSIS"] -->|"target for"| DIABETIC_RETINOPATHY
    BCL2["BCL2"] -->|"target for"| DIABETIC_RETINOPATHY
    NF_KB["NF-KB"] -->|"target for"| DIABETIC_RETINOPATHY

Outgoing (233)

Target	Relation	Type	Str
Retinopathy	therapeutic_target	disease	1.00
Als	therapeutic_target	disease	0.95
retinal ganglion cells	causes	cell_type	0.95
WIF1	downregulates	protein	0.90
NEURODEGENERATION	causes	gene	0.90
Retinopathy	associated_with	disease	0.85
Diabetes	associated_with	disease	0.85
Diabetes	causes	disease	0.85
Retinal Neurodegeneration	causes	phenotype	0.85
Retinal Barrier Breakdown	causes	phenotype	0.85
Diabetes	activates	disease	0.85
Retinal Microvascular Deterioration	causes	phenotype	0.85
Inflammation	therapeutic_target	disease	0.75
Als	associated_with	disease	0.75
Retinopathy	activates	disease	0.75
Neurodegeneration	protects_against	disease	0.75
Senescence	therapeutic_target	disease	0.75
Diabetes	therapeutic_target	disease	0.75
Als	interacts_with	disease	0.75
Retinopathy	causes	disease	0.75
Apoptosis	activates	pathway	0.70
Apoptosis	therapeutic_target	pathway	0.70
Mitochondrial Function	therapeutic_target	pathway	0.70
Als	protects_against	disease	0.65
Cardiovascular	interacts_with	disease	0.65
Stroke	interacts_with	disease	0.65
Dementia	interacts_with	disease	0.65
Tumor	contributes_to	disease	0.65
Neuroinflammation	protects_against	disease	0.65
Inflammation	protects_against	disease	0.65
Diabetes	protects_against	disease	0.65
Macular Degeneration	associated_with	disease	0.65
Glaucoma	associated_with	disease	0.65
Osteoporosis	activates	disease	0.65
Atherosclerosis	activates	disease	0.65
Nephropathy	associated_with	disease	0.65
Tumor	therapeutic_target	disease	0.65
Ischemia	treats	disease	0.65
Hypertension	biomarker_for	disease	0.65
Retinopathy	biomarker_for	disease	0.65
Ischemia	biomarker_for	disease	0.65
Diabetes	biomarker_for	disease	0.65
Aging	interacts_with	disease	0.65
Senescence	interacts_with	disease	0.65
Als	activates	disease	0.65
Alzheimer	associated_with	disease	0.65
Hypertension	associated_with	disease	0.65
Atherosclerosis	associated_with	disease	0.65
Stroke	associated_with	disease	0.65
Ms	associated_with	disease	0.65

Incoming (160)

Source	Relation	Type	Str
DIABETES MELLITUS	causes	gene	1.00
VEGFA	involved_in	gene	0.95
VEGFA	therapeutic_target	gene	0.95
Type 2 Diabetes Mellitus	causes	disease	0.95
5'tiRNA-His-GTG	biomarker_for	biomarker	0.95
Diabetes	causes	disease	0.95
FTO	contributes_to	protein	0.90
Downregulation Of 5'tiRNA-His-GTG	protects_against	mechanism	0.90
HDAC3	involved_in	gene	0.90
Neuroinflammation	contributes_to	process	0.88
WIF1	treats	protein	0.85
Microvascular Anomalies	contributes_to	phenotype	0.85
Anti-Vascular Endothelial Growth Factor Therapies	treats	drug	0.85
WIF1	protects_against	protein	0.85
BCL2	biomarker_for	gene	0.80
DAAO	associated_with	gene	0.80
miR-195	promotes	gene	0.80
Targeting 5'Tirna-His-Gtg	treats	mechanism	0.80
VDR	therapeutic_target	gene	0.80
NPY	implicated_in	gene	0.80
BCL2	protects_against	protein	0.75
plasma proteins	contributes_to	protein	0.75
NEURODEGENERATION	protects_against	gene	0.70
VEGF	protects_against	gene	0.70
NF-κB pathway	activates	pathway	0.70
DIABETES MELLITUS	associated_with	gene	0.70
miRNA	regulates	protein	0.70
oxidative stress	associated_with	process	0.70
MITOCHONDRIA	therapeutic_target	gene	0.70
APOPTOSIS	activates	gene	0.70
INFLAMMATION	therapeutic_target	gene	0.70
SRR	associated_with	gene	0.70
APOPTOSIS	therapeutic_target	gene	0.70
VEGF	therapeutic_target	gene	0.70
HSP90AA1	therapeutic_target	gene	0.60
CANCER	therapeutic_target	gene	0.60
PI3K	associated_with	gene	0.60
FN1	interacts_with	gene	0.60
GENES	interacts_with	gene	0.60
C-JUN	activates	gene	0.60
FOS	activates	gene	0.60
SIRT1	activates	gene	0.60
C-FOS	activates	gene	0.60
GPX4	regulates	gene	0.60
OXIDATIVE STRESS	expressed_in	gene	0.60
AND	expressed_in	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
ROS	expressed_in	gene	0.60
CD4	associated_with	gene	0.60
BCL2	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning DIABETIC RETINOPATHY in their description or question text

No additional research found