concept

TNF SIGNALING

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TNF SIGNALING: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

89Connections

0Hypotheses

0Analyses

22Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	TNF SIGNALING
Key Genes/Proteins	AKT, AKT1, CASP3, CTSD, CXCL10, IL1B
Related Diseases	ALZHEIMER'S DISEASE, APOPTOSIS, disease, INFLAMMATION
Related Pathways	inflammation

Pathway Diagram

graph TD
    TNF_SIGNALING["TNF SIGNALING"]
    VEGFA["VEGFA"] -->|"target for"| TNF_SIGNALING
    TNF__["TNF-Alpha"] -->|"target for"| TNF_SIGNALING
    Tumor["Tumor"] -->|"target for"| TNF_SIGNALING
    TNF["TNF"] -->|"inhibits"| TNF_SIGNALING
    INFLAMMATION["INFLAMMATION"] -->|"activates"| TNF_SIGNALING
    Inflammation["Inflammation"] -->|"activates"| TNF_SIGNALING
    AKT1["AKT1"] -->|"target for"| TNF_SIGNALING
    IL6["IL6"] -->|"target for"| TNF_SIGNALING
    EGF["EGF"] -->|"target for"| TNF_SIGNALING

Outgoing (22)

Target	Relation	Type	Str
cancer	therapeutic_target	disease	0.83
IL6	targets	gene	0.65
MMP9	targets	gene	0.65
IL-17	regulates	concept	0.50
MAPK SIGNALING	regulates	concept	0.50
IL-17	expressed_in	concept	0.50
CASP3	associated_with	gene	0.45
PI3K	associated_with	gene	0.45
MAPK	associated_with	gene	0.45
IL1B	associated_with	gene	0.45
AKT	associated_with	gene	0.45
IL6	associated_with	gene	0.45
INFLAMMATION	associated_with	phenotype	0.45
APOPTOSIS	associated_with	phenotype	0.45
MMP9	associated_with	gene	0.45
MICROGLIA	associated_with	cell_type	0.45
TNF	associated_with	gene	0.45
CXCL10	associated_with	gene	0.45
PARP1	associated_with	gene	0.45
CTSD	associated_with	gene	0.45
STROKE	associated_with	disease	0.45
RIPK1	associated_with	gene	0.45

Incoming (67)

Source	Relation	Type	Str
RUBCNL	inhibits	protein	0.88
TNF-Α	therapeutic_target	gene	0.70
Tumor	therapeutic_target	disease	0.70
Inflammation	activates	disease	0.70
INFLAMMATION	activates	gene	0.70
TNF	inhibits	gene	0.70
VEGFA	therapeutic_target	gene	0.70
TNF	transports	gene	0.65
ALZHEIMER'S DISEASE	activates	disease	0.65
Asthma	activates	disease	0.60
KRAS	regulates	gene	0.60
CANCER	therapeutic_target	gene	0.60
Cancer	therapeutic_target	disease	0.60
Aging	regulates	disease	0.60
Carcinoma	regulates	disease	0.60
Pancreatic Cancer	therapeutic_target	disease	0.60
Tumor	regulates	disease	0.60
FERROPTOSIS	inhibits	gene	0.60
Tumor	activates	disease	0.60
GPX4	activates	gene	0.60
AKT1	therapeutic_target	gene	0.60
IL6	therapeutic_target	gene	0.60
EGF	therapeutic_target	gene	0.60
PARP1	therapeutic_target	gene	0.60
PI3K	therapeutic_target	gene	0.60
TNF	associated_with	gene	0.60
AKT	therapeutic_target	gene	0.60
Depression	associated_with	disease	0.60
INFLAMMATION	therapeutic_target	gene	0.60
STROKE	implicated_in	gene	0.60
NEUROINFLAMMATION	therapeutic_target	gene	0.60
Als	therapeutic_target	disease	0.60
Neuroinflammation	therapeutic_target	disease	0.60
Stroke	implicated_in	disease	0.60
Inflammation	therapeutic_target	disease	0.60
CYTOKINES	activates	gene	0.60
NF-ΚB	therapeutic_target	gene	0.60
IL-6	therapeutic_target	gene	0.60
Neuropathy	inhibits	disease	0.60
CXCL1	regulates	gene	0.60
DEPRESSION	associated_with	gene	0.60
SYNAPSE	associated_with	gene	0.60
TP53	regulates	gene	0.60
GENES	associated_with	gene	0.60
TNFR2	regulates	gene	0.60
TNF	therapeutic_target	gene	0.60
disease	inhibits	disease	0.50
NEURODEGENERATIVE DISEASE	inhibits	concept	0.50
IL1B	expressed_in	gene	0.50
TNF-α	expressed_in	concept	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TNF SIGNALING in their description or question text

No additional research found