| Gene Symbol | SOCS3 |
| Full Name | Suppressor of Cytokine Signaling 3 |
| Aliases | Page for SOCS3 |
| Chromosome | 17q25.3 |
| Function | encodes a key negative feedback regulator of the JAK-STAT signaling pathway, one of the primary intracellular signaling cascades mediating cytokine and growth factor responses. |
| Amino Acids | 225 aa |
| Pathways | JAK-STAT signaling, jak-stat, NF-κB |
| Ensembl ID | ENSG00000184557 |
| GeneCards | SOCS3 |
| Human Protein Atlas | SOCS3 |
| IL-10 | Limits anti-inflammatory IL-10 signaling duration |
| Leptin receptor | Contributes to leptin resistance |
| G-CSF/EPO receptors | Regulates hematopoietic cytokine signaling |
| Aβ-driven inflammation | Amyloid-beta oligomers activate JAK-STAT3 signaling in microglia and astrocytes. Inadequate SOCS3 feedback allows sustained IL-6, TNF-α, and complement production |
| Associated Diseases | neurodegeneration |
| Interactions | Actin, AMPK, AND, APOPTOSIS, ATP, AUTOPHAGY |
| KG Connections | 216 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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