gene

S100A9

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about S100A9: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

307Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

S100A9 is a gene implicated in neurodegeneration research. Key relationships include: expressed in, activates, associated with. Associated with ALI, Als, Atherosclerosis. Connected to 88 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	S100A9
Full Name	S100 Calcium Binding Protein A9
Chromosome	1q21.3
Protein Family	S100 calcium-binding protein family
Function	S100A9, particularly as part of calprotectin (S100A8/A9), has diverse functions
Molecular Weight	13.2 kDa
Amino Acids	113 aa
Exons	3
Pathways	NF-κB, MAPK signaling
GeneCards	S100A9
Human Protein Atlas	S100A9
EF-hand I (pseudo)	N-terminal non-functional calcium-binding site
EF-hand II (canonical)	C-terminal functional calcium-binding site
Hydrophobic patches	Mediate interaction with S100A8 and target proteins
C-terminal extension	Involved in dimerization and target recognition
Associated Diseases	Als, Ms, Neuroinflammation, Sepsis, stroke
Known Drugs/Compounds	GW201
Interactions	ACE2, Actin, AGING, AIFM1, ALDH1A1, ALZHEIMER
KG Connections	307 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

S100A9 - S100 Calcium Binding Protein A9

gene · 963 words

→

S100A9 Protein - Calgranulin B

protein · 698 words

→

Pathway Diagram

graph TD
    S100A9["S100A9"]
    ALI{"ALI"}
    S100A9 -->|"activates"| ALI
    ALDH1A1["ALDH1A1"]
    S100A9 -->|"activates"| ALDH1A1
    brain_metastasis(["brain metastasis"])
    S100A9 -->|"activates"| brain_metastasis
    osimertinib_resistance(["osimertinib resistance"])
    S100A9 -->|"activates"| osimertinib_resistance
    lung_cancer_progression(["lung cancer progression"])
    S100A9 -->|"biomarker for"| lung_cancer_progression
    INFLAMMATION["INFLAMMATION"]
    S100A9 -->|"activates"| INFLAMMATION
    Ms{"Ms"}
    S100A9 -->|"associated with"| Ms
    Sepsis{"Sepsis"}
    S100A9 -->|"activates"| Sepsis
    S100A9 -->|"expressed in"| Ms
    Cancer{"Cancer"}
    S100A9 -->|"activates"| Cancer
    Neuroinflammation{"Neuroinflammation"}
    S100A9 -->|"expressed in"| Neuroinflammation
    Inflammation{"Inflammation"}
    S100A9 -->|"expressed in"| Inflammation
    MMP9["MMP9"]
    MMP9 -->|"associated with"| S100A9
    BAX["BAX"]
    BAX -->|"activates"| S100A9
    GENES["GENES"]
    GENES -->|"activates"| S100A9
    S100A8["S100A8"]
    S100A8 -->|"associated with"| S100A9
    APOPTOSIS["APOPTOSIS"]
    APOPTOSIS -->|"activates"| S100A9
    S100A8 -->|"activates"| S100A9
    CANCER["CANCER"]
    CANCER -->|"activates"| S100A9
    OCLN["OCLN"]
    OCLN -->|"expressed in"| S100A9
    IL1RN["IL1RN"]
    IL1RN -->|"expressed in"| S100A9
    MICROGLIA["MICROGLIA"]
    MICROGLIA -->|"expressed in"| S100A9
    MIRNAS["MIRNAS"]
    MIRNAS -->|"expressed in"| S100A9
    ASTROCYTES["ASTROCYTES"]
    ASTROCYTES -->|"expressed in"| S100A9
    style S100A9 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (201)

Target	Relation	Type	Str
Neuroinflammation	involved_in	process	0.85
AGING	upregulates	process	0.80
Inflammation	expressed_in	disease	0.75
ALI	activates	disease	0.72
apoptosis pathway	participates_in	pathway	0.70
ALDH1A1	activates	protein	0.70
osimertinib resistance	activates	process	0.70
brain metastasis	activates	process	0.70
lung cancer progression	biomarker_for	process	0.70
INFLAMMATION	activates	phenotype	0.68
Lung Cancer	inhibits	disease	0.65
ALS	activates	disease	0.65
Aging	activates	disease	0.65
Fibrosis	inhibits	disease	0.65
Alzheimer	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
Parkinson	activates	disease	0.65
Atherosclerosis	expressed_in	disease	0.65
Als	biomarker_for	disease	0.65
Cancer	expressed_in	disease	0.65
Als	inhibits	disease	0.65
Inflammation	regulates	disease	0.65
Fibrosis	activates	disease	0.65
ALS	expressed_in	disease	0.65
Neuroinflammation	regulates	disease	0.65
Tumor	therapeutic_target	disease	0.65
Cancer	activates	disease	0.65
Als	associated_with	disease	0.65
Multiple Sclerosis	interacts_with	disease	0.65
Obesity	inhibits	disease	0.65
Ms	associated_with	disease	0.65
Sepsis	activates	disease	0.65
Ms	expressed_in	disease	0.65
Neuroinflammation	implicated_in	disease	0.65
Als	activates	disease	0.65
Neuroinflammation	expressed_in	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Inflammation	inhibits	disease	0.65
Stroke	inhibits	disease	0.65
IL17	activates	protein	0.64
S100A8	expressed_in	gene	0.60
CLDN1	expressed_in	gene	0.60
NLRP1	inhibits	gene	0.60
IL31	expressed_in	gene	0.60
IL18	inhibits	gene	0.60
TFAM	inhibits	gene	0.60
BAX	activates	gene	0.60
NLRP3	inhibits	gene	0.60
S100A8	associated_with	gene	0.60

Incoming (106)

Source	Relation	Type	Str
GW201	modulates	compound	0.85
HBV	associated_with	biological_process	0.80
BAX	activates	gene	0.60
S100A8	associated_with	gene	0.60
IL1B	associated_with	gene	0.60
SOD2	associated_with	gene	0.60
MARCKS	associated_with	gene	0.60
LAMP1	associated_with	gene	0.60
MBP	associated_with	gene	0.60
LAMP2	associated_with	gene	0.60
ALDH1A1	therapeutic_target	gene	0.60
BAX	targets	gene	0.60
IL-17	activates	gene	0.60
RNA	expressed_in	gene	0.60
CYTOKINES	activates	gene	0.60
COMPLEMENT	activates	gene	0.60
MTDNA	activates	gene	0.60
COX2	inhibits	gene	0.60
RNA	regulates	gene	0.60
ACE2	activates	gene	0.60
HMGB2	activates	gene	0.60
MMP9	associated_with	gene	0.60
S100A8	regulates	gene	0.60
MAPK14	activates	gene	0.60
MAPK1	activates	gene	0.60
BAX	associated_with	gene	0.60
CCL3	activates	gene	0.60
OVERVIEW	activates	gene	0.60
MAPK1	targets	gene	0.60
MAPK14	targets	gene	0.60
MAPK1	associated_with	gene	0.60
MAPK14	associated_with	gene	0.60
CLDN1	inhibits	gene	0.60
CCL26	expressed_in	gene	0.60
LOR	expressed_in	gene	0.60
GENES	activates	gene	0.60
AUTOPHAGY	expressed_in	gene	0.60
MTORC1	expressed_in	gene	0.60
APOPTOSIS	activates	gene	0.60
CANCER	expressed_in	gene	0.60
NF-ΚB	activates	gene	0.60
OCLN	expressed_in	gene	0.60
IL1RN	expressed_in	gene	0.60
MMP3	expressed_in	gene	0.60
IL1R1	expressed_in	gene	0.60
SERPINA3	expressed_in	gene	0.60
MTOR	expressed_in	gene	0.60
RPS6KB1	expressed_in	gene	0.60
IFNG	expressed_in	gene	0.60
S100A8	expressed_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning S100A9 in their description or question text

No additional research found