gene

il30

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about il30: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

22Connections

0Hypotheses

0Analyses

8Outgoing

14Incoming

0Experiments

0Debates

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🧬 Gene Info

Gene Symbol	IL30
Full Name	Interleukin 30 (p28 Subunit)
Chromosome	1p13.1
Function	encodes a secreted glycoprotein that plays critical roles in immune regulation, particularly in the context of neuroinflammation, autoimmunity, and potentially neurodegenerative diseases.
Primary Expression	Immune cells, CNS microglia, astrocytes
Molecular Weight	27 kDa
Amino Acids	241 aa
Exons	5
UniProt ID	Q8TD97
NCBI Gene ID	359710
GeneCards	IL30
Human Protein Atlas	IL30
IL27RA (WSX-1)	The specific IL-27 receptor alpha chain, expressed primarily on T cells, NK cells, and some myeloid cells
GP130	The common signaling subunit shared with other cytokine receptors (IL-6, LIF, OSM)
Associated Diseases	Prostate Cancer
Interactions	CXCL5, IGF1, NFKB1
KG Connections	22 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: il30 — AlphaFold Q8TD97 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

IL30 — Interleukin 30 (p28 Subunit)

gene · 1804 words

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Pathway Diagram

graph TD
    IL30["IL30"]
    IL30 -->|"inhibits"| Liver_Injury["Liver Injury"]
    IL30 -->|"expressed in"| Hepatocytes["Hepatocytes"]
    IL30 -->|"inhibits"| IGF1["IGF1"]
    IL30 -->|"inhibits"| CXCL5["CXCL5"]
    IL30 -->|"upregulates"| SOCS3["SOCS3"]
    IL30 -->|"inhibits"| Cancer["Cancer"]
    IL30 -->|"implicated in"| neurodegeneration["neurodegeneration"]
    EGF["EGF"] -->|"expressed in"| IL30
    HGF["HGF"] -->|"expressed in"| IL30
    CCL2["CCL2"] -->|"expressed in"| IL30
    VEGFA["VEGFA"] -->|"expressed in"| IL30
    CDH1["CDH1"] -->|"expressed in"| IL30
    ANG["ANG"] -->|"expressed in"| IL30
    PLG["PLG"] -->|"expressed in"| IL30
    PTEN["PTEN"] -->|"expressed in"| IL30

Outgoing (8)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:IL30	data_in	dataset_row	0.00
Liver Injury	inhibits	disease	0.90
Hepatocytes	expressed_in	cell_type	0.90
IGF1	inhibits	gene	0.80
CXCL5	inhibits	gene	0.80
SOCS3	upregulates	gene	0.80
Prostate Cancer	associated_with	disease	0.80
Cancer	inhibits	disease	0.65

Incoming (14)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:IL30	data_in	dataset_row	0.00
IL12	associated_with	gene	0.80
IFN-Γ	associated_with	gene	0.80
CD3	associated_with	receptor	0.80
CCL2	expressed_in	gene	0.60
CDH1	expressed_in	gene	0.60
EGF	expressed_in	gene	0.60
VEGFA	expressed_in	gene	0.60
ANG	expressed_in	gene	0.60
PLG	expressed_in	gene	0.60
PTEN	expressed_in	gene	0.60
EFNB2	expressed_in	gene	0.60
HGF	expressed_in	gene	0.60
NFKB1	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning il30 in their description or question text

No additional research found