gene

CXCL1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CXCL1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

466Connections

2Hypotheses

2Analyses

50Outgoing

50Incoming

1Experiments

4Debates

Summary

C-X-C motif chemokine ligand 1 (GROα) - pro-inflammatory chemokine involved in neuroinflammation, glial activation, and neurodegenerative disease pathogenesis.

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🧬 Gene Info

Gene Symbol	CXCL1
Aliases	C-X-C motif chemokine ligand 1 (GROα)
Protein Type	Receptor
Primary Expression	blood-brain barrier
Amino Acids	107 aa
Pathways	Chemoresistance, Cholesterol, Tnf Signaling, Toll-Like Receptor, Tumor Microenvironment
Ensembl ID	ENSG00000163425
GeneCards	CXCL1
Human Protein Atlas	CXCL1
Associated Diseases	Alzheimer, Inflammation, Ms, neurodegeneration, Neuroinflammation, Pancreatic Cancer
Known Drugs/Compounds	rapamycin
Interactions	Akt, AKT, AND, APOE, App, ASTROCYTES
KG Connections	466 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (7)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CXCL1["CXCL1"]
    CXCL1 -->|"target for"| Ms["Ms"]
    CXCL1 -->|"target for"| Als["Als"]
    CXCL1 -->|"target for"| Atherosclerosis["Atherosclerosis"]
    CXCL1 -->|"target for"| Cardiovascular["Cardiovascular"]
    CXCL1 -->|"inhibits"| Inflammation["Inflammation"]
    CXCL1 -->|"expressed in"| Tumor["Tumor"]
    CXCL1 -->|"activates"| Alzheimer["Alzheimer"]
    CXCL1 -->|"activates"| Neuroinflammation["Neuroinflammation"]
    CXCL2["CXCL2"] -->|"inhibits"| CXCL1
    IL6["IL6"] -->|"inhibits"| CXCL1
    ATF4["ATF4"] -->|"target for"| CXCL1
    PPP1R15A["PPP1R15A"] -->|"target for"| CXCL1
    IL12B["IL12B"] -->|"inhibits"| CXCL1
    XBP1["XBP1"] -->|"target for"| CXCL1
    IL1B["IL1B"] -->|"regulates"| CXCL1
    TLR2["TLR2"] -->|"regulates"| CXCL1
    DDIT3["DDIT3"] -->|"target for"| CXCL1
    CLDN5["CLDN5"] -->|"inhibits"| CXCL1

Outgoing (299)

Target	Relation	Type	Str
Inflammation	activates	disease	1.00
Als	activates	disease	0.95
Cancer	activates	disease	0.85
Nf-Κb	activates	pathway	0.80
Infection	activates	disease	0.75
Tumor	regulates	disease	0.75
Carcinoma	regulates	disease	0.75
Tumor	expressed_in	disease	0.75
Neuroinflammation	activates	disease	0.75
Inflammation	associated_with	disease	0.75
TNF	activates	gene	0.70
Mapk	activates	pathway	0.70
CANCER	activates	gene	0.70
Inflammasome	activates	pathway	0.70
Ms	associated_with	disease	0.65
Tumor	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Rheumatoid Arthritis	associated_with	disease	0.65
Senescence	associated_with	disease	0.65
Cancer	inhibits	disease	0.65
Tumor	therapeutic_target	disease	0.65
ALS	activates	disease	0.65
Ms	therapeutic_target	disease	0.65
Neurodegeneration	activates	disease	0.65
Alzheimer	activates	disease	0.65
Depression	protects_against	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Ms	activates	disease	0.65
Inflammation	inhibits	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Tumor	activates	disease	0.65
Als	therapeutic_target	disease	0.65
Atherosclerosis	inhibits	disease	0.65
Als	inhibits	disease	0.65
Cardiac	inhibits	disease	0.65
Fibrosis	inhibits	disease	0.65
Atherosclerosis	therapeutic_target	disease	0.65
Ms	inhibits	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
Sepsis	causes	disease	0.65
Depression	treats	disease	0.65
Neuroinflammation	causes	disease	0.65
Sepsis	therapeutic_target	disease	0.65
Inflammation	causes	disease	0.65
Pancreatic Cancer	associated_with	disease	0.65
ALS	inhibits	disease	0.65
Cardiovascular	inhibits	disease	0.65
Cardiovascular	regulates	disease	0.65
Als	regulates	disease	0.65
Alzheimer	regulates	disease	0.65

Incoming (167)

Source	Relation	Type	Str
Astrocytes	product_of	cell_type	0.90
INFLAMMATION	activates	gene	0.90
Dolutegravir	upregulates	drug	0.87
DTG	upregulates	drug	0.85
AKT	upregulates	gene	0.80
Endoplasmic Reticulum Stress	upregulates	process	0.80
IL-6	activates	gene	0.80
CYTOKINES	activates	gene	0.80
NF-ΚB	activates	gene	0.80
PI3K	activates	gene	0.70
TNF	regulates	gene	0.70
CANCER	activates	gene	0.70
TNF-Α	activates	gene	0.70
NF-KB	activates	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
IL8	associated_with	gene	0.60
ERK	activates	gene	0.60
AND	regulates	gene	0.60
NF-ΚB	associated_with	gene	0.60
AND	inhibits	gene	0.60
GENES	regulates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
IL-17	associated_with	gene	0.60
HUB GENES	regulates	gene	0.60
ASTROCYTE	protects_against	gene	0.60
CCL2	protects_against	gene	0.60
DEPRESSION	protects_against	gene	0.60
PERIPHERAL IMMUNE CELL INFILTRATION	protects_against	gene	0.60
AND	protects_against	gene	0.60
ASTROCYTES	protects_against	gene	0.60
IL1B	regulates	gene	0.60
TLR2	regulates	gene	0.60
CXCL8	regulates	gene	0.60
ICAM1	associated_with	gene	0.60
MMP9	regulates	gene	0.60
TLR3	activates	gene	0.60
NLRP3	activates	gene	0.60
P38	activates	gene	0.60
OPTINEURIN	associated_with	gene	0.60
CD4	inhibits	gene	0.60
CD8	therapeutic_target	gene	0.60
HSPA5	therapeutic_target	gene	0.60
DDIT3	therapeutic_target	gene	0.60
CLDN5	inhibits	gene	0.60
IL23A	inhibits	gene	0.60
OCLN	inhibits	gene	0.60
APOE	regulates	gene	0.60
NLRP1	expressed_in	gene	0.60
TNF	activates	gene	0.60
BDNF	expressed_in	gene	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
SASP Secretome-based Molecular Distinction via CXCL1/CXCL2/M	0.720	neurodegeneration	How can senescent microglia be molecular
White Matter Oligodendrocyte Protection via CXCL10 Inhibitio	0.675	neurodegeneration	Gene expression changes in aging mouse b

Mentioning Analyses (2)

Scientific analyses that reference this entity

Does CXCL10 inhibition compromise CNS immune surveillance during chronic treatme

neuroimmunology | 2026-04-11 | 0 hypotheses

Systemic immune profiling and peripheral immune contributions to neurodegenerati

neurodegeneration | 2026-04-04 | 0 hypotheses

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
CXCL10 biomarker analysis for CPSP prediction	clinical	chronic postsurgical pain	0.900	0.00	human patients undergoing thor	proposed	N/A

Related Papers (10)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
METTL3/CXCL10 axis contributes to renal fibrosis by promoting the apoptosis of t [PMID:41138934]	Sun Y, Ren Z, Ge J, Zhang W, Shao F et a	Biochim Biophys Acta Mol Basis	2026
IL-25-ILC2-IL-13 axis improves traumatic brain injury by mediating CXCL-10-depen [PMID:41527095]	Peng M, Shu D, Chen Z, Yang Z, Zhang M e	J Neuroinflammation	2026
Oligodendrocyte transcription factor 2 orchestrates glioblastoma immune evasion [PMID:41591814]	Zhang X, Xue J, Zhao C, Zeng C, Zhong J	J Clin Invest	2026
Indole-3-propionic acid inhibits astrocyte inflammation and promotes motor funct [PMID:41663028]	Yu D, Kang J, Jiang W, Zhang C, Zhao X e	Neuropharmacology	2026
Cobrotoxin mitigates neuroinflammation and cognitive impairment by suppressing C [PMID:41671614]	Li Z, Tan B, Dong K, Yu X, Zhang SW et a	Biochem Pharmacol	2026
Peripheral macrophages and T-cells accumulate in the degenerating optic tract af [PMID:41740873]	Main BS, Villapol S, Buenaventura RG, Ha	Brain Behav Immun	2026
Melanoma cell inoculation improves cognitive impairment in the 5xFAD mouse model [PMID:41760781]	Bruna-Jara B, More J, Lobos P, Ponce DP,	Scientific reports	2026
Chemokine-defined macrophage niches establish spatial organization of tumor immu [PMID:41872505]	Ghosh S, Li X, Rawat K, Dighal A, Kalino	Nat Immunol	2026
Agonists for cytosolic bacterial receptor ALPK1 induce antitumour immunity. [PMID:41372408]	Tian X, Liu J, Li Y, Wang Y, Luo Y, He H	Nature	2026
HTLV1-associated myelopathy as a translational model of progressive neurodegener [PMID:41926707]	da Silva MTT, Araujo AQC	Brain : a journal of neurology	2026

Debates (4)

Multi-agent debates referencing this entity

The debate highlighted major safety concerns about blocking CXCL10, particularly

closed · Rounds: 4 · Score: 1.00 · 2026-04-20

How do peripheral immune system alterations influence CNS pathology and neurodeg

closed · Rounds: 4 · Score: 0.76 · 2026-04-12

How do peripheral immune system alterations influence CNS pathology and neurodeg

closed · Rounds: 4 · Score: 0.78 · 2026-04-12

How do peripheral immune system alterations influence CNS pathology and neurodeg

closed · Rounds: 4 · Score: 0.50 · 2026-04-11

Related Research

Hypotheses and analyses mentioning CXCL1 in their description or question text

No additional research found

CXCL1

Understanding Entity Pages

Summary

Wiki Pages (7)

CXCL1

CXCL12 (SDF-1) - Stromal Cell-Derived Factor 1

CXCL12/CXCR4 Signaling Pathway in Neurodegeneration

CXCL12/CXCR4 Axis Modulator Therapy for Neurodegeneration

CXCL12/SDF-1 Protein

CXCL12 Gene

CXCL10 - C-X-C Motif Chemokine Ligand 10

Pathway Diagram

Outgoing (299)

Incoming (167)

Targeting Hypotheses (2)

Mentioning Analyses (2)

Does CXCL10 inhibition compromise CNS immune surveillance during chronic treatme

Systemic immune profiling and peripheral immune contributions to neurodegenerati

Experiments (1)

Related Papers (10)

Debates (4)

The debate highlighted major safety concerns about blocking CXCL10, particularly

How do peripheral immune system alterations influence CNS pathology and neurodeg

How do peripheral immune system alterations influence CNS pathology and neurodeg

How do peripheral immune system alterations influence CNS pathology and neurodeg

Related Research