gene

HSPB1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HSPB1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

321Connections

1Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

HSPB1 is a gene implicated in neurodegeneration research. Key relationships include: activates, associated with, expressed in. Associated with ALS, Aging, Als. Connected to 177 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	HSPB1
Aliases	Hsp27
Chromosome	7q11.23.
Molecular Weight	27 kDa
Amino Acids	205 aa
Pathways	MAPK Pathway, NF-κB, PI3K
GeneCards	HSPB1
Human Protein Atlas	HSPB1
Associated Diseases	Aging, Als, Alzheimer, Cardiovascular, disease, Ms
Interactions	Actin, ALS, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AMYOTROPHIC LATERAL SCLEROSIS
SciDEX Hypotheses	HSPB1 Phosphorylation Mimetics to Promote Protecti
KG Connections	321 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (4)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    HSPB1["HSPB1"]
    HSPB1 -.protects against.-> neurodegeneration["neurodegeneration"]
    HSPB1 -->|"regulates"| poly_G_aggregates["poly-G aggregates"]
    HSPB1 -->|"target for"| Multiple_Sclerosis["Multiple Sclerosis"]
    HSPB1 -->|"target for"| Alzheimer["Alzheimer"]
    HSPB1 -->|"regulates"| Ms["Ms"]
    HSPB1 -->|"target for"| Parkinson["Parkinson"]
    HSPB1 -->|"inhibits"| Cancer["Cancer"]
    HSPB1 -->|"inhibits"| Als["Als"]
    STAT3["STAT3"] -->|"regulates"| HSPB1
    CEBPA["CEBPA"] -->|"target for"| HSPB1
    HSPA1A["HSPA1A"] -->|"regulates"| HSPB1
    TFE3["TFE3"] -->|"target for"| HSPB1
    TP53["TP53"] -->|"target for"| HSPB1
    SPI1["SPI1"] -->|"target for"| HSPB1
    GENES["GENES"] -->|"regulates"| HSPB1
    CTSH["CTSH"] -->|"interacts"| HSPB1
    COMPLEMENT["COMPLEMENT"] -->|"interacts"| HSPB1

Outgoing (177)

Target	Relation	Type	Str
Apoptosis	inhibits	process	0.90
Alzheimer's Disease	upregulates	disease	0.85
Multiple Sclerosis	upregulates	disease	0.85
Parkinson's Disease	upregulates	disease	0.85
Parkinson	expressed_in	disease	0.75
Inflammation	activates	disease	0.75
Neurodegeneration	activates	disease	0.75
neurodegeneration	protects_against	process	0.70
poly-G aggregates	regulates	process	0.70
Ms	regulates	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Cancer	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Als	inhibits	disease	0.65
Sepsis	therapeutic_target	disease	0.65
Aging	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
Alzheimer	associated_with	disease	0.65
Multiple Sclerosis	associated_with	disease	0.65
Multiple Sclerosis	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
ALS	inhibits	disease	0.65
Ms	activates	disease	0.65
Ischemia	activates	disease	0.65
Amyotrophic Lateral Sclerosis	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Parkinson	activates	disease	0.65
Aging	associated_with	disease	0.65
Cardiovascular	associated_with	disease	0.65
Als	activates	disease	0.65
Stroke	activates	disease	0.65
Als	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Alzheimer	expressed_in	disease	0.65
Multiple Sclerosis	expressed_in	disease	0.65
Ms	associated_with	disease	0.65
Alzheimer	protects_against	disease	0.65
Neurodegeneration	biomarker_for	disease	0.65
Ms	expressed_in	disease	0.65
Parkinson	associated_with	disease	0.65
Als	associated_with	disease	0.65
Neuroinflammation	interacts_with	disease	0.65
Inflammation	interacts_with	disease	0.65
Alzheimer	interacts_with	disease	0.65
apoptosis	inhibits	phenotype	0.64
NEURODEGENERATION	activates	gene	0.60
PARKINSON	associated_with	gene	0.60
AGING	expressed_in	gene	0.60
NEURON	expressed_in	gene	0.60

Incoming (144)

Source	Relation	Type	Str
h-ff0d545d	targets_gene	hypothesis	0.90
SPI1	regulates	gene	0.80
CEBPA	regulates	gene	0.80
HSP90AA1	regulates	protein	0.80
TP53	regulates	entity	0.70
INFLAMMATION	activates	gene	0.70
STAT3	regulates	protein	0.70
NEURODEGENERATION	activates	gene	0.70
PARKINSON'S DISEASE	expressed_in	gene	0.70
NOS1	interacts_with	gene	0.60
IL6	interacts_with	gene	0.60
NEUROINFLAMMATION	interacts_with	gene	0.60
APOE	interacts_with	gene	0.60
SERPINA3	interacts_with	gene	0.60
PRDX6	interacts_with	gene	0.60
MT1A	interacts_with	gene	0.60
CD44	interacts_with	gene	0.60
SOD1	interacts_with	gene	0.60
OXIDATIVE STRESS	interacts_with	gene	0.60
MAPK1	interacts_with	gene	0.60
CLU	interacts_with	gene	0.60
TNF	interacts_with	gene	0.60
NFE2L2	interacts_with	gene	0.60
AND	associated_with	gene	0.60
MMP1	interacts_with	gene	0.60
ASTROCYTES	interacts_with	gene	0.60
ALZHEIMER'S DISEASE	interacts_with	gene	0.60
CEBPA	associated_with	gene	0.60
ICAM1	associated_with	gene	0.60
CXCL1	associated_with	gene	0.60
NEURODEGENERATIVE DISEASES	therapeutic_target	gene	0.60
SOCS3	associated_with	gene	0.60
IL6	associated_with	gene	0.60
MICROGLIA	therapeutic_target	gene	0.60
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.60
ZFP36	therapeutic_target	gene	0.60
IL-6	therapeutic_target	gene	0.60
PARKINSON'S DISEASE	therapeutic_target	gene	0.60
TP53	expressed_in	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
NEURODEGENERATIVE DISEASES	contributes_to	gene	0.60
SPI1	expressed_in	gene	0.60
CEBPA	expressed_in	gene	0.60
ALZHEIMER'S DISEASE	expressed_in	gene	0.60
GENES	activates	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
MAPK	inhibits	gene	0.60
AGING	expressed_in	gene	0.60
NEURON	expressed_in	gene	0.60
SYNAPSE	expressed_in	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
HSPB1 Phosphorylation Mimetics to Promote Protective TDP-43	0.820	neurodegeneration	What is the therapeutic window between i

Mentioning Analyses (1)

Scientific analyses that reference this entity

What is the therapeutic window between insufficient and toxic levels of TDP-43 a

neurodegeneration | 2026-04-12 | 2 hypotheses Top: 0.848

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The debate highlighted a critical dosing paradox where both hypo- and hypermethy

closed · Rounds: 4 · Score: 0.82 · 2026-04-12

Related Research

Hypotheses and analyses mentioning HSPB1 in their description or question text

No additional research found