gene

RELB

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RELB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

95Connections

0Hypotheses

0Analyses

50Outgoing

19Incoming

0Experiments

0Debates

Summary

RELB is a gene implicated in neurodegeneration research. Key relationships include: regulates, activates, expressed in. Associated with Aging, Als, Breast Cancer. Connected to 83 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	NF
Full Name	κB RelB Protein
Aliases	RELB
Chromosome	19
Function	Nf Κb P105 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
GeneCards	NF
Human Protein Atlas	NF
Associated Diseases	Als, Cancer, Carcinoma, Lung Cancer, Melanoma, Tumor
Interactions	CANCER, IGF1, INFLAMMATION, NF-ΚB, RPS6KB1, TNF
KG Connections	95 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    RELB["RELB"]
    Inflammation{"Inflammation"}
    RELB -->|"activates"| Inflammation
    Aging{"Aging"}
    RELB -->|"activates"| Aging
    Ms{"Ms"}
    RELB -->|"activates"| Ms
    RELB -->|"expressed in"| Inflammation
    P2RY1["P2RY1"]
    RELB -->|"regulates"| P2RY1
    CASP3["CASP3"]
    RELB -->|"regulates"| CASP3
    SOCS3["SOCS3"]
    RELB -->|"regulates"| SOCS3
    TRPA1["TRPA1"]
    RELB -->|"regulates"| TRPA1
    GENES["GENES"]
    RELB -->|"regulates"| GENES
    CXCL2["CXCL2"]
    RELB -->|"regulates"| CXCL2
    SNAP25["SNAP25"]
    RELB -->|"regulates"| SNAP25
    P2RX7["P2RX7"]
    RELB -->|"regulates"| P2RX7
    PANX1["PANX1"]
    PANX1 -->|"regulates"| RELB
    S100B["S100B"]
    S100B -->|"regulates"| RELB
    style RELB fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (76)

Target	Relation	Type	Str
Als	activates	disease	0.85
Inflammation	activates	disease	0.75
Cancer	activates	disease	0.75
Nf-Κb	activates	pathway	0.70
Tumor	associated_with	disease	0.65
Melanoma	associated_with	disease	0.65
Als	regulates	disease	0.65
Cancer	regulates	disease	0.65
Cancer	associated_with	disease	0.65
Lung Cancer	associated_with	disease	0.65
Carcinoma	associated_with	disease	0.65
Aging	activates	disease	0.65
Ms	activates	disease	0.65
Inflammation	expressed_in	disease	0.65
Tumor	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Carcinoma	expressed_in	disease	0.65
Breast Cancer	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Als	associated_with	disease	0.65
SYT2	regulates	gene	0.60
TNF	regulates	gene	0.60
SOD2	regulates	gene	0.60
NOS2	regulates	gene	0.60
P2RX3	regulates	gene	0.60
RELA	regulates	gene	0.60
SYP	regulates	gene	0.60
CHRNA7	regulates	gene	0.60
SYT1	regulates	gene	0.60
STAT3	regulates	gene	0.60
HMOX1	regulates	gene	0.60
TRPV1	regulates	gene	0.60
P2RY2	regulates	gene	0.60
FOXP3	regulates	gene	0.60
TPH2	regulates	gene	0.60
CCL3	regulates	gene	0.60
Nf-Κb	interacts_with	pathway	0.60
Nf-Kb	expressed_in	pathway	0.60
P2RY1	regulates	gene	0.60
Nf-Κb	therapeutic_target	pathway	0.60
CASP3	regulates	gene	0.60
SOCS3	regulates	gene	0.60
TRPA1	regulates	gene	0.60
CXCL2	regulates	gene	0.60
SNAP25	regulates	gene	0.60
P2RX7	regulates	gene	0.60
APOE	expressed_in	gene	0.60
RPS6KB1	interacts_with	gene	0.60
NOTCH1	expressed_in	gene	0.60
INFLAMMATION	expressed_in	gene	0.60

Incoming (19)

Source	Relation	Type	Str
CANCER	activates	gene	0.70
NF-KB	expressed_in	gene	0.60
NF-ΚB	interacts_with	gene	0.60
NF-ΚB	therapeutic_target	gene	0.60
INFLAMMATION	therapeutic_target	gene	0.60
CANCER	therapeutic_target	gene	0.60
NF-ΚB	activates	gene	0.60
CANCER	associated_with	gene	0.60
REL	expressed_in	gene	0.60
RELA	expressed_in	gene	0.60
REL	therapeutic_target	gene	0.60
RELA	therapeutic_target	gene	0.60
PANX1	regulates	gene	0.60
S100B	regulates	gene	0.60
CXCL12	associated_with	gene	0.60
FOXM1	causes	gene	0.60
IL6	associated_with	gene	0.60
NR1H3	causes	gene	0.60
INFLAMMATION	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity