gene

OSMR

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about OSMR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

57Connections

0Hypotheses

0Analyses

34Outgoing

23Incoming

0Experiments

0Debates

Summary

OSMR encodes the Oncostatin M receptor, a type I cytokine receptor mediating IL-6 family signaling. Critical regulator of neuroinflammation implicated in Alzheimer's disease, Parkinson's disease, ALS, and multiple sclerosis through JAK/STAT3, MAPK/ERK, and PI3K/Akt pathways.

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🧬 Gene Info

Gene Symbol	OSMR
Full Name	Oncostatin M Receptor
Chromosome	5p13.1
Protein Type	Receptor
Function	encodes a type I cytokine receptor that mediates signaling from IL-6 family cytokines, primarily Oncostatin M (OSM) and Leukemia Inhibitory Factor (LIF) [@breedlove2020].
Primary Expression	the CNS, with particularly high levels on reactive astrocytes surrounding sites of pathology
Molecular Weight	110 kDa
Amino Acids	979 aa
Exons	12
Pathways	MAPK, PI3K, PI3K pathway
UniProt ID	Q08357
NCBI Gene ID	9184
Ensembl ID	ENSG00000120708
OMIM	601095
GeneCards	OSMR
Human Protein Atlas	OSMR
Associated Diseases	Als, Alzheimer, Cancer Cachexia, Dementia, Inflammation, Ms
Interactions	Actin, ATP, AUTOPHAGY, Caspase, COX2, DRP1
KG Connections	57 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: OSMR — AlphaFold Q08357 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

OSMR Gene

gene · 2066 words

→

OSMR Protein

protein · 632 words

→

Pathway Diagram

graph TD
    OSMR["OSMR"]
    Dementia{"Dementia"}
    OSMR -->|"associated with"| Dementia
    Alzheimer{"Alzheimer"}
    OSMR -->|"associated with"| Alzheimer
    Als{"Als"}
    OSMR -->|"associated with"| Als
    Inflammation{"Inflammation"}
    OSMR -->|"associated with"| Inflammation
    Ms{"Ms"}
    OSMR -->|"associated with"| Ms
    OSMR -->|"expressed in"| Ms
    Cancer{"Cancer"}
    OSMR -->|"expressed in"| Cancer
    Glioblastoma{"Glioblastoma"}
    OSMR -->|"expressed in"| Glioblastoma
    CTSD["CTSD"]
    OSMR -->|"associated with"| CTSD
    CCL3["CCL3"]
    OSMR -->|"associated with"| CCL3
    GFAP["GFAP"]
    OSMR -->|"associated with"| GFAP
    Dna_Methylation(["Dna Methylation"])
    OSMR -->|"expressed in"| Dna_Methylation
    VEGF["VEGF"]
    VEGF -->|"associated with"| OSMR
    TNF["TNF"]
    TNF -->|"associated with"| OSMR
    MYD88["MYD88"]
    MYD88 -->|"associated with"| OSMR
    CANCER["CANCER"]
    CANCER -->|"expressed in"| OSMR
    GBM["GBM"]
    GBM -->|"associated with"| OSMR
    style OSMR fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (34)

Target	Relation	Type	Str
Cancer Cachexia	associated_with	disease	0.90
Ms	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
Glioblastoma	expressed_in	disease	0.65
Ms	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Als	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Dementia	associated_with	disease	0.65
Caspase	activates	protein	0.60
Actin	activates	protein	0.60
Ras	activates	protein	0.60
VEGF	associated_with	gene	0.60
LCN2	expressed_in	gene	0.60
AUTOPHAGY	activates	gene	0.60
Oxidative Stress	activates	pathway	0.60
Mitochondrial Function	activates	pathway	0.60
Dna Methylation	expressed_in	pathway	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
INFLAMMATION	associated_with	gene	0.60
Amyloid	associated_with	pathway	0.60
SST	biomarker_for	gene	0.60
DRP1	activates	gene	0.60
CASP4	expressed_in	gene	0.60
SOCS3	expressed_in	gene	0.60
Rb	activates	protein	0.60
Nfkb	expressed_in	protein	0.60
Neuron	therapeutic_target	cell_type	0.60
App	therapeutic_target	protein	0.60
CTSD	associated_with	gene	0.60
CCL3	associated_with	gene	0.60
GFAP	associated_with	gene	0.60
Neuron	expressed_in	cell_type	0.55
SST	co_discussed	gene	0.50

Incoming (23)

Source	Relation	Type	Str
S100A8	expressed_in	gene	0.60
S100A9	expressed_in	gene	0.60
TFAM	activates	gene	0.60
MYD88	associated_with	gene	0.60
GBM	associated_with	gene	0.60
GFAP	associated_with	gene	0.60
CCL3	associated_with	gene	0.60
CTSD	associated_with	gene	0.60
AMYLOID	associated_with	gene	0.60
DEMENTIA	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
AND	associated_with	gene	0.60
COX2	activates	gene	0.60
ATP	activates	gene	0.60
MTDNA	activates	gene	0.60
CANCER	expressed_in	gene	0.60
GENES	biomarker_for	gene	0.60
AND	regulates	gene	0.60
VEGF	associated_with	gene	0.60
TNF	associated_with	gene	0.60
SST	biomarker_for	gene	0.60
GENES	co_discussed	gene	0.50
NEURON	co_discussed	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning OSMR in their description or question text

No additional research found