gene

P2RY1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about P2RY1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

226Connections

15Hypotheses

4Analyses

50Outgoing

50Incoming

0Experiments

4Debates

Summary

The P2RY1 gene encodes the P2Y1 purinergic receptor, a G protein-coupled receptor for ADP and ATP that plays important roles in platelet activation, neuroinflammation, and neurodegenerative disease pathogenesis.

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🧬 Gene Info

Gene Symbol	P2RY1
Full Name	Purinergic Receptor P2Y1
Chromosome	19p13.2
Protein Family	P2Y receptor family (GPCR)
Protein Type	Gpcr
Target Class	Gpcr
Function	GPCR antagonists or agonists modulating purinergic signaling
Mechanism of Action	GPCR antagonists or agonists modulating purinergic signaling
Druggability	Low (0.41)
Clinical Stage	Phase I
Molecular Weight	41 kDa
Exons	2
Pathways	Spontaneous Bursting Activity
UniProt ID	P47900
NCBI Gene ID	5028
Ensembl ID	ENSG00000142203
OMIM	181010
GeneCards	P2RY1
Human Protein Atlas	P2RY1
Associated Diseases	Als, ALZHEIMER, DIABETES, epilepsy
Known Drugs/Compounds	MRS2500
Interactions	adora2b, ADORA2B, AND, ATP, F3, GENES
SciDEX Target	View Target Profile (2 clinical trials)
KG Connections	226 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: P2RY1 — AlphaFold P47900 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (5)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    P2RY1["P2RY1
Purinergic Receptor"]
    
    ADP["ADP
Ligand"]
    P2RX7["P2RX7
Ion Channel"]
    P2RX4["P2RX4
Ion Channel"]
    PANX1["PANX1
Pannexin Channel"]
    
    INFLAMMATION["Neuroinflammation
Process"]
    MICROGLIA["Microglial
Activation"]
    ATP_RELEASE["ATP Release
Signaling"]
    
    ALS["Amyotrophic
Lateral Sclerosis"]
    MS["Multiple
Sclerosis"]
    NEURODEGENERATION["Neurodegeneration
Pathology"]
    
    NEUROPROTECTION["Neuroprotective
Effects"]
    THERAPEUTIC["Therapeutic
Targeting"]
    
    ADP -->|"activates"| P2RY1
    P2RY1 -->|"interacts with"| P2RX7
    P2RY1 -->|"activates"| PANX1
    P2RY1 -->|"modulates"| P2RX4
    
    P2RY1 -->|"activates"| INFLAMMATION
    INFLAMMATION -->|"leads to"| MICROGLIA
    P2RX7 -->|"promotes"| ATP_RELEASE
    PANX1 -->|"facilitates"| ATP_RELEASE
    
    P2RY1 -->|"dual role"| ALS
    P2RY1 -->|"dual role"| MS
    ALS -->|"contributes to"| NEURODEGENERATION
    MS -->|"contributes to"| NEURODEGENERATION
    
    P2RY1 -->|"can provide"| NEUROPROTECTION
    P2RY1 -->|"potential"| THERAPEUTIC
    
    style P2RY1 fill:#006494
    style NEUROPROTECTION fill:#1b5e20
    style THERAPEUTIC fill:#1b5e20
    style INFLAMMATION fill:#ef5350
    style NEURODEGENERATION fill:#ef5350
    style ALS fill:#ef5350
    style MS fill:#ef5350
    style P2RX7 fill:#4a1a6b
    style PANX1 fill:#4a1a6b
    style ATP_RELEASE fill:#5d4400
    style MICROGLIA fill:#5d4400

Outgoing (155)

Target	Relation	Type	Str
LUNG TISSUE	expressed_in	entity	0.95
UPREGULATES	upregulates	entity	0.95
THERAPEUTIC_TARGET	therapeutic_target	entity	0.90
IMMUNE CELLS	expressed_in	entity	0.90
GLUCOSE HOMEOSTASIS	regulates	entity	0.85
Lung Tissue	expressed_in	cell_type	0.85
Glucose Homeostasis	regulates	process	0.70
P2RX7	interacts_with	gene	0.66
neurodegeneration	associated_with	disease	0.66
Als	activates	disease	0.65
Ms	protects_against	disease	0.65
Ms	associated_with	disease	0.65
Diabetes	protects_against	disease	0.65
Epilepsy	associated_with	disease	0.65
ALS	associated_with	disease	0.65
Covid	activates	disease	0.65
Als	protects_against	disease	0.65
Ms	activates	disease	0.65
Inflammation	activates	disease	0.65
ALS	protects_against	disease	0.65
glycemic traits	associated_with	phenotype	0.65
Als	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Aging	activates	disease	0.65
P2RX7	protects_against	gene	0.60
SOCS3	regulates	gene	0.60
CASP3	regulates	gene	0.60
P2X7	associated_with	gene	0.60
TRPA1	regulates	gene	0.60
CXCL2	regulates	gene	0.60
P2RY12	activates	gene	0.60
CD38	associated_with	gene	0.60
PANX1	activates	gene	0.60
P2RX1	activates	gene	0.60
CCL3	regulates	gene	0.60
TPH2	regulates	gene	0.60
P2RX4	activates	gene	0.60
P2RX5	activates	gene	0.60
ADORA2B	activates	gene	0.60
HMOX1	regulates	gene	0.60
P2RX7	activates	gene	0.60
P2RX4	expressed_in	gene	0.60
STAT3	regulates	gene	0.60
TRPV1	regulates	gene	0.60
P2RY2	regulates	gene	0.60
FOXP3	regulates	gene	0.60
SYT1	regulates	gene	0.60
P2RX7	therapeutic_target	gene	0.60
P2RX1	expressed_in	gene	0.60
CHRNA7	regulates	gene	0.60

Incoming (71)

Source	Relation	Type	Str
h-0758b337	targets	hypothesis	0.80
P2RX7	interacts_with	gene	0.66
P2RX7	associated_with	gene	0.60
MICROGLIA	associated_with	gene	0.60
P2RX1	therapeutic_target	gene	0.60
P2RX4	therapeutic_target	gene	0.60
P2RX7	therapeutic_target	gene	0.60
P2RY14	therapeutic_target	gene	0.60
ADORA2B	activates	gene	0.60
P2RY12	activates	gene	0.60
P2RX1	activates	gene	0.60
P2RX4	activates	gene	0.60
P2RX7	activates	gene	0.60
CD38	associated_with	gene	0.60
SYNAPSE	associated_with	gene	0.60
MGLUR5	associated_with	gene	0.60
F3	activates	gene	0.60
ALOX12	associated_with	gene	0.60
AR	associated_with	gene	0.60
HO1	associated_with	gene	0.60
ASTROCYTES	protects_against	gene	0.60
P2X7	associated_with	gene	0.60
MGLUR1	associated_with	gene	0.60
ATP	associated_with	gene	0.60
ATP	therapeutic_target	gene	0.60
NAD	associated_with	gene	0.60
EPILEPSY	associated_with	gene	0.60
PER	associated_with	gene	0.60
ASTROCYTES	associated_with	gene	0.60
ASTROCYTE	associated_with	gene	0.60
ATP	activates	gene	0.60
ATP	protects_against	gene	0.60
PANX1	regulates	gene	0.60
S100B	regulates	gene	0.60
RELB	regulates	gene	0.60
P2RX4	protects_against	gene	0.60
P2RX7	protects_against	gene	0.60
P2RX1	expressed_in	entity	0.60
P2RX4	expressed_in	entity	0.60
P2RX7	expressed_in	entity	0.60
ADORA2B	regulates	entity	0.60
P2RX1	regulates	entity	0.60
P2RX4	regulates	entity	0.60
P2RX5	regulates	entity	0.60
P2RX7	regulates	entity	0.60
P2RX4	associated_with	entity	0.60
P2RX5	activates	gene	0.60
PANX1	activates	gene	0.60
ATP	expressed_in	gene	0.60
P2RY14	expressed_in	gene	0.60

Targeting Hypotheses (15)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
TNF-α/NF-κB Axis Upregulates P2RY12 in VSMCs	0.650	neurodegeneration	What determines P2RY12 receptor expressi
P2RY12-mediated autophagy inhibition in cerebral VSMCs impai	0.605	neurodegeneration	How does P2RY12-mediated VSMC dysfunctio
P2RY12-driven autophagy impairment in cerebral VSMCs mediate	0.585	neurodegeneration	How does P2RY12-mediated VSMC dysfunctio
Pharmacological P2RY12 inhibition (ticagrelor/clopidogrel) a	0.583	neurodegeneration	How does P2RY12-mediated VSMC dysfunctio
TREM2-P2RY12 Balance Restoration Therapy	0.571	neurodegeneration	Neuroinflammation and microglial priming

oxLDL/LOX-1/ROS Signaling Induces P2RY12 via Nrf2 Activation	0.550	neurodegeneration	What determines P2RY12 receptor expressi
miR-143/145 Cluster Dysregulation Derepresses P2RY12 Transcr	0.520	neurodegeneration	What determines P2RY12 receptor expressi
LRP1 Loss-of-Function Derepresses P2RY12 Expression	0.500	neurodegeneration	What determines P2RY12 receptor expressi
P2RY12/P2RY13 Purinergic Receptor Metabolic Rewiring	0.490	neuroinflammation	What molecular mechanisms mediate SPP1-i
Platelet-Derived PDGF-BB Primes VSMCs for P2RY12 Upregulatio	0.480	neurodegeneration	What determines P2RY12 receptor expressi
KLF4-Mediated Transcriptional Repression of P2RY12	0.440	neurodegeneration	What determines P2RY12 receptor expressi
DNA Hypomethylation at P2RY12 Promoter Correlates with Disea	0.440	neurodegeneration	What determines P2RY12 receptor expressi
P2RY12-mediated cerebral VSMC dysfunction establishes a vici	0.418	neurodegeneration	How does P2RY12-mediated VSMC dysfunctio
P2RY12 activation induces cellular senescence in cerebral VS	0.373	neurodegeneration	How does P2RY12-mediated VSMC dysfunctio
P2RY12 rs2046934 polymorphism modifies neurodegeneration ris	0.273	neurodegeneration	How does P2RY12-mediated VSMC dysfunctio

Mentioning Analyses (4)

Scientific analyses that reference this entity

What determines P2RY12 receptor expression/activity specifically in VSMCs during

neurodegeneration | 2026-04-07 | 7 hypotheses Top: 0.650

How does P2RY12-mediated VSMC dysfunction contribute to cerebrovascular neurodeg

neurodegeneration | 2026-04-07 | 7 hypotheses Top: 0.605

Neuroinflammation and microglial priming in early Alzheimer's Disease

neurodegeneration | 2026-04-04 | 0 hypotheses

Astrocyte reactivity subtypes in neurodegeneration

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.741

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (13)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
The gain-of-function TREM2-T96K mutation increases risk for Alzheimer's disease [PMID:41109213]	Pilat DJ, Le H, Prokopenko D, Lin CJ, Ei	Neuron	2026
Role of TREM2 in neuroinflammation. [PMID:41213496]	Abdulkhaliq AA, Alasiri G, Almoghrabi Y,	Exp Neurol	2026
Targeting Itga8 Mitigates Neurogenic Bladder Fibrosis Driven by Trem2⁺ Macrophag [PMID:41355531]	Wang J, Wang S, Ren L, Liu X, Zhang L et	Adv Sci (Weinh)	2026
Hepatocyte Mettl3 Deficiency Drives Primary Sclerosing Cholangitis and Liver Fib [PMID:41431138]	Pan W, Yong Y, Li Y, Shi G, Zhang M et a	Adv Sci (Weinh)	2026
Synergistic potential of TREM2 agonists and exercise training in Alzheimer's dis [PMID:41494649]	Zhang J, St Pierre Schneider B, Muguerza	Am J Physiol Endocrinol Metab	2026
Sulfatide deficiency-induced astrogliosis and myelin lipid dyshomeostasis are in [PMID:41513633]	He S, Mittra N, Bao H, Bhattacharjee A,	Nat Commun	2026
Peripheral cancer attenuates amyloid pathology in Alzheimer's disease via cystat [PMID:41576952]	Li X, Tang X, Zeng J, Duan L, Hou Z et a	Cell	2026
TREM2 expression level is critical for microglial state, metabolic capacity and [PMID:41580393]	Feiten AF, Dahm K, Schlepckow K, van Len	Nat Commun	2026
TREM2 in neurodegeneration and diseases. [PMID:41792456]	["Abdulkhaliq A", "Alasiri G", "Kim B",	Molecular psychiatry	2026
Alzheimer's Disease as a Disorder of Neuroimmune Dysregulation. [PMID:41745721]	Aranda-Abreu GE, Rojas-Durán F, Hernánde	Neurology international	2026
The microglial TREM2 receptor programs hippocampal development in a mouse model [PMID:41887542]	Ahmed S, Bowers C, Munoz-Martin J, Jamwa	Brain, behavior, and immunity	2026
Molecular mechanism of Alzheimer's disease using integrated multi-omics. [PMID:41907842]	Alhusaini M, Mussa BM, Ilce BY, Alhaj H,	Frontiers in aging neuroscienc	2026
Viral and non-viral cellular therapies for neurodegeneration. [PMID:41585268]	["Srivastav Jyotsna", "Sharma Sachin"]	Frontiers in medicine	2025

Debates (4)

Multi-agent debates referencing this entity

While the study establishes P2RY12's role in VSMC foam cell formation in atheros

closed · Rounds: 4 · Score: 0.62 · 2026-04-21

The study shows P2RY12 regulates VSMC foam cell formation but doesn't explain wh

closed · Rounds: 4 · Score: 0.66 · 2026-04-21

Astrocyte reactivity subtypes in neurodegeneration

closed · Rounds: 4 · Score: 0.95 · 2026-04-10

Neuroinflammation and microglial priming in early Alzheimer's Disease

closed · Rounds: 2 · Score: 0.95 · 2026-04-04

Related Research

Hypotheses and analyses mentioning P2RY1 in their description or question text

P2RY1

Understanding Entity Pages

Summary

Wiki Pages (5)

P2RY1 Gene

P2RY13 Protein

P2RY14 Gene - Purinergic Receptor P2Y14

P2RY12 Gene

P2RY13

Pathway Diagram

Outgoing (155)

Incoming (71)

Targeting Hypotheses (15)

Mentioning Analyses (4)

What determines P2RY12 receptor expression/activity specifically in VSMCs during

How does P2RY12-mediated VSMC dysfunction contribute to cerebrovascular neurodeg

Neuroinflammation and microglial priming in early Alzheimer's Disease

Astrocyte reactivity subtypes in neurodegeneration

Experiments (0)

Related Papers (13)

Debates (4)

While the study establishes P2RY12's role in VSMC foam cell formation in atheros

The study shows P2RY12 regulates VSMC foam cell formation but doesn't explain wh

Astrocyte reactivity subtypes in neurodegeneration

Neuroinflammation and microglial priming in early Alzheimer's Disease

Related Research

oxLDL/LOX-1/ROS Signaling Induces P2RY12 via Nrf2 Activation

miR-143/145 Cluster Dysregulation Derepresses P2RY12 Transcription

LRP1 Loss-of-Function Derepresses P2RY12 Expression

P2RY12/P2RY13 Purinergic Receptor Metabolic Rewiring

Platelet-Derived PDGF-BB Primes VSMCs for P2RY12 Upregulation

KLF4-Mediated Transcriptional Repression of P2RY12

DNA Hypomethylation at P2RY12 Promoter Correlates with Disease Progression

P2RY12-mediated cerebral VSMC dysfunction establishes a vicious cycle with micro

P2RY12 activation induces cellular senescence in cerebral VSMCs, driving neurode

P2RY12 rs2046934 polymorphism modifies neurodegeneration risk by altering cerebr