Contents

SMAD3 — SMAD Family Member 3

🧬 Gene Info

Gene Symbol	SMAD3
Full Name	SMAD Family Member 3
Chromosome	15q22.33
Protein Type	Transcription Factor
Function	encodes a transcription factor that serves as a central mediator of TGF-β (Transforming Growth Factor Beta) signaling.
Primary Expression	Brain (cortex, hippocampus, substantia nigra), Lung, Heart, Blood vessels
Molecular Weight	48 kDa
Pathways	TGF-β, TGF-β signaling
UniProt ID	P84022
NCBI Gene ID	4088
Ensembl ID	ENSG00000166949
OMIM	603109
GeneCards	SMAD3
Human Protein Atlas	SMAD3
Linker domain	Contains regulatory phosphorylation sites and interaction motifs for various kinases
Associated Diseases	Aging, Als, Alzheimer, Crohn'S Disease, Diabetes
Known Drugs/Compounds	lycopene
Interactions	ABCG2, ACTB, adamts4, ADAMTS4, AGING, AKT
KG Connections	370 knowledge graph edges
Databases	GeneCards HPA STRING

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