gene

PLK1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PLK1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

90Connections

0Hypotheses

0Analyses

50Outgoing

35Incoming

0Experiments

0Debates

Summary

PLK1 encodes Polo-like kinase 1, a master mitotic regulator critical for cell division and implicated in neurodegeneration

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🧬 Gene Info

Gene Symbol	PLK1
Chromosome	16p12.2
Protein Type	Gene
Function	is a serine/threonine protein kinase that functions as a master regulator of mitosis.
Primary Expression	post-mitotic neurons and functions in synaptic plasticity, axonal repair, and DNA damage response has opened new research avenues for understanding PL
Amino Acids	603 aa
Pathways	Autophagy, Cell Cycle
GeneCards	PLK1
Human Protein Atlas	PLK1
Associated Diseases	ALS
Interactions	ALS, AMYOTROPHIC LATERAL SCLEROSIS, AND, APOPTOSIS, App, BUB1
KG Connections	90 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

PLK1 Gene

gene · 1727 words

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Pathway Diagram

graph TD
    PLK1["PLK1"]
    Als{"Als"}
    PLK1 -->|"regulates"| Als
    Tumor{"Tumor"}
    PLK1 -->|"activates"| Tumor
    Carcinoma{"Carcinoma"}
    PLK1 -->|"therapeutic target"| Carcinoma
    Cancer{"Cancer"}
    PLK1 -->|"activates"| Cancer
    PLK1 -->|"inhibits"| Tumor
    CANCER["CANCER"]
    PLK1 -->|"activates"| CANCER
    APOPTOSIS["APOPTOSIS"]
    PLK1 -->|"activates"| APOPTOSIS
    TERT["TERT"]
    PLK1 -->|"inhibits"| TERT
    SMAD3["SMAD3"]
    PLK1 -->|"inhibits"| SMAD3
    Apoptosis(["Apoptosis"])
    PLK1 -->|"activates"| Apoptosis
    neurodegeneration["neurodegeneration"]
    PLK1 -->|"implicated in"| neurodegeneration
    style PLK1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (55)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:PLK1	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
Carcinoma	therapeutic_target	disease	0.75
Cancer	regulates	disease	0.65
Tumor	inhibits	disease	0.65
Amyotrophic Lateral Sclerosis	encodes	disease	0.65
Als	encodes	disease	0.65
Cancer	activates	disease	0.65
Inflammation	regulates	disease	0.65
Als	activates	disease	0.65
Tumor	activates	disease	0.65
Pancreatic Cancer	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Tumor	therapeutic_target	disease	0.65
Amyotrophic Lateral Sclerosis	activates	disease	0.65
Als	regulates	disease	0.65
Wnt	activates	pathway	0.60
Neuron	activates	cell_type	0.60
PI3K	associated_with	gene	0.60
CDK1	associated_with	gene	0.60
AKT	associated_with	gene	0.60
APOPTOSIS	associated_with	gene	0.60
CANCER	therapeutic_target	gene	0.60
BCL-2	associated_with	gene	0.60
Pi3K/Akt	associated_with	pathway	0.60
Cell Cycle	associated_with	pathway	0.60
Apoptosis	associated_with	pathway	0.60
Tumor Microenvironment	therapeutic_target	pathway	0.60
Ras	regulates	protein	0.60
App	activates	protein	0.60
neurons	expressed_in	cell_type	0.60
TERT	inhibits	gene	0.60
SMAD3	inhibits	gene	0.60
ALS	associated_with	disease	0.60
FUS	activates	gene	0.60
AND	regulates	gene	0.60
DNA	associated_with	gene	0.60
RNA	encodes	gene	0.60
Wnt	encodes	pathway	0.60
CANCER	activates	gene	0.60
Cell Cycle	encodes	pathway	0.60
APOPTOSIS	activates	gene	0.60
Apoptosis	activates	pathway	0.60
AUTOPHAGY	regulates	gene	0.60
Cell Cycle	regulates	pathway	0.60
Autophagy	regulates	pathway	0.60
RNA	activates	gene	0.60
oxidative stress response	participates_in	pathway	0.60
CDK1	regulates	gene	0.60
Cell Cycle	activates	pathway	0.60

Incoming (35)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:PLK1	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00
FUS	causes	gene	0.60
MMP9	activates	gene	0.60
FUS	expressed_in	gene	0.60
DNA	regulates	gene	0.60
BUB1	activates	gene	0.60
FUS	encodes	gene	0.60
CDK1	activates	gene	0.60
MKI67	activates	gene	0.60
WNT	activates	gene	0.60
DNA	associated_with	gene	0.60
ALS	activates	gene	0.60
RNA	activates	gene	0.60
FUS	activates	gene	0.60
C-MYC	regulates	gene	0.60
CANCER	regulates	gene	0.60
WNT	encodes	gene	0.60
ALS	encodes	gene	0.60
DNA	activates	gene	0.60
ALS	causes	gene	0.60
MYC	regulates	gene	0.60
AND	regulates	gene	0.60
SYNAPSE	activates	gene	0.60
INFLAMMATION	regulates	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	activates	gene	0.60
MOTOR NEURONS	activates	gene	0.60
AND	activates	gene	0.60
MMP1	activates	gene	0.60
MMP1	co_expressed_with	gene	0.50
MMP9	co_expressed_with	gene	0.50
FUS	regulates	gene	0.50
NEURON	co_discussed	gene	0.50
RNA	regulates	gene	0.50
GENES	co_discussed	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PLK1 in their description or question text

No additional research found