gene

WWOX

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about WWOX: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

54Connections

0Hypotheses

0Analyses

45Outgoing

9Incoming

0Experiments

0Debates

Summary

WWOX is a gene implicated in neurodegeneration research. Key relationships include: activates, inhibits, interacts with. Associated with Als, Alzheimer, Cancer. Connected to 46 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	WWOX
Full Name	WW Domain Containing Oxidoreductase
Chromosome	16q23.1
Function	encodes a tumor suppressor protein with two WW domains and a short-chain dehydrogenase/reductase (SDR) domain.
Primary Expression	the brain, particularly in the cerebellum, cortex, and hippocampus
Amino Acids	414 aa
Pathways	Apoptosis, Tgf-Β
UniProt ID	Q9H0M0
NCBI Gene ID	54345
OMIM	605515
GeneCards	WWOX
Human Protein Atlas	WWOX
Brain	High expression in cerebellum, cortex, and hippocampus
Peripheral tissues	Moderate expression in lung, breast, ovary
Cellular localization	Cytoplasm, synaptic vesicles, mitochondria
Associated Diseases	Alzheimer, Carcinoma
Interactions	ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, APOPTOSIS, APP, CANCER
KG Connections	54 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: WWOX — AlphaFold Q9H0M0 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

WWOX Gene

gene · 967 words

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Pathway Diagram

graph TD
    WWOX["WWOX"]
    Carcinoma{"Carcinoma"}
    WWOX -->|"associated with"| Carcinoma
    Als{"Als"}
    WWOX -->|"expressed in"| Als
    Cancer{"Cancer"}
    WWOX -->|"regulates"| Cancer
    Tumor{"Tumor"}
    WWOX -->|"expressed in"| Tumor
    CANCER["CANCER"]
    WWOX -->|"regulates"| CANCER
    CDH1["CDH1"]
    WWOX -->|"expressed in"| CDH1
    VIM["VIM"]
    WWOX -->|"expressed in"| VIM
    MMP2["MMP2"]
    WWOX -->|"activates"| MMP2
    neurodegeneration["neurodegeneration"]
    WWOX -->|"implicated in"| neurodegeneration
    MMP9["MMP9"]
    MMP9 -->|"activates"| WWOX
    style WWOX fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (45)

Target	Relation	Type	Str
Cancer	inhibits	disease	0.75
CANCER	inhibits	gene	0.70
Cancer	regulates	disease	0.65
Tumor	expressed_in	disease	0.65
Carcinoma	associated_with	disease	0.65
Als	expressed_in	disease	0.65
Tumor	inhibits	disease	0.65
Alzheimer	inhibits	disease	0.65
Lung Cancer	inhibits	disease	0.65
Neurodegeneration	activates	disease	0.65
Inflammation	inhibits	disease	0.65
Alzheimer	associated_with	disease	0.65
Neurodegeneration	interacts_with	disease	0.65
Tumor	activates	disease	0.65
P53	activates	gene	0.60
TAU TANGLES	inhibits	gene	0.60
AMYLOID	inhibits	gene	0.60
INFLAMMATION	inhibits	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
ERK	interacts_with	gene	0.60
Nf-Κb	interacts_with	pathway	0.60
NEURODEGENERATION	interacts_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
NF-ΚB	interacts_with	gene	0.60
autophagy pathway	participates_in	pathway	0.60
VIM	expressed_in	gene	0.60
MMP2	activates	gene	0.60
TAU	inhibits	gene	0.60
JNK	interacts_with	gene	0.60
Tgf-Β	activates	pathway	0.60
TAU	activates	gene	0.60
SMAD3	activates	gene	0.60
SMAD4	activates	gene	0.60
P38	activates	gene	0.60
CANCER	regulates	gene	0.60
APP	activates	gene	0.60
CDH1	expressed_in	gene	0.60
APOPTOSIS	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
ALZHEIMER	inhibits	gene	0.60
P53	inhibits	gene	0.60
AMYLOID	activates	gene	0.60
ALZHEIMER'S DISEASE	inhibits	gene	0.60
Apoptosis	activates	pathway	0.60
Immune Response	inhibits	pathway	0.60

Incoming (9)

Source	Relation	Type	Str
CDKL5	associated_with	gene	0.60
HCN1	associated_with	gene	0.60
KCNQ2	associated_with	gene	0.60
PLCB1	associated_with	gene	0.60
SCN1A	associated_with	gene	0.60
SCN2A	associated_with	gene	0.60
SCN8A	associated_with	gene	0.60
STXBP1	associated_with	gene	0.60
MMP9	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning WWOX in their description or question text

No additional research found