Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about adamts4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | ADAMTS4 |
| Protein Type | Protease |
| Function | ADAMTS4 encodes a member of the ADAMTS (A Disintegrin And Metalloproteinase with Thrombospondin motifs) family of secreted zinc metalloproteinases. |
| Subcellular Localization | Secreted enzyme; localized to the extracellular space and cell surface |
| Exons | 8 |
| Pathways | Circadian Rhythm, Tgf-Β, TGF-beta signaling |
| Ensembl ID | ENSG00000158859 |
| GeneCards | ADAMTS4 |
| Human Protein Atlas | ADAMTS4 |
| Extracellular matrix (ECM) remodeling | ADAMTS-4 cleaves aggrecan and other proteoglycans (versican, brevican, neurocan) in the ECM, facilitating tissue remodeling during development and repair |
| Perineuronal net (PNN) degradation | Cleaves brevican and other chondroitin sulfate proteoglycans (CSPGs) that form PNNs, structures critical for synaptic stability and neural plasticity |
| Amyloid-beta clearance | Identified as an amyloid-beta (Aβ)-degrading enzyme that can cleave Aβ peptides, potentially contributing to amyloid homeostasis in the brain |
| Neuroinflammatory modulation | Expression is upregulated in reactive astrocytes and microglia during neuroinflammation |
| Spinal cord plasticity | Promotes axonal regeneration and plasticity after spinal cord injury by degrading inhibitory CSPGs |
| Amyloid-beta degradation | ADAMTS-4 cleaves Aβ at multiple sites within the peptide, representing a novel Aβ-degrading pathway complementary to neprilysin and insulin-degrading enzyme |
| Associated Diseases | Alzheimer's Disease (AD |
| Interactions | BMAL1, SMAD3 |
| KG Connections | 5 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
ADAMTS4["ADAMTS4"]
ADAMTS4 -->|"inhibits"| FBN1["FBN1"]
ADAMTS4 -->|"activates"| Aging["Aging"]
ADAMTS4 -->|"activates"| Ms["Ms"]
ADAMTS4 -->|"activates"| SMAD3["SMAD3"]
ADAMTS4 -->|"activates"| Circadian_Rhythm["Circadian Rhythm"]
ADAMTS4 -->|"activates"| Tgf__["Tgf-Beta"]
ADAMTS4 -->|"activates"| BMAL1["BMAL1"]
BMAL1 -->|"inhibits"| ADAMTS4
SMAD3 -->|"activates"| ADAMTS4
AGING["AGING"] -->|"activates"| ADAMTS4| Target | Relation | Type | Str |
|---|---|---|---|
| APP | cleaves | protein | 0.90 |
| FBN1 | inhibits | protein | 0.72 |
| Aging | activates | disease | 0.65 |
| Aging | regulates | disease | 0.65 |
| Ms | activates | disease | 0.65 |
| Rb | activates | protein | 0.60 |
| senescence | participates_in | pathway | 0.60 |
| Circadian Rhythm | activates | pathway | 0.60 |
| Tgf-Β | activates | pathway | 0.60 |
| Alzheimer's disease | interacts_with | disease | 0.60 |
| AGING | activates | gene | 0.60 |
| Osteoclast | activates | cell_type | 0.60 |
| AND | activates | gene | 0.60 |
| SMAD3 | activates | gene | 0.60 |
| Endothelial | activates | cell_type | 0.60 |
| Stem Cell | activates | cell_type | 0.60 |
| Metalloproteinase | activates | protein | 0.60 |
| endothelial cells | expressed_in | cell_type | 0.60 |
| TGF-beta signaling | participates_in | pathway | 0.60 |
| TGF | activates | gene | 0.60 |
| BIN1 | interacts_with | gene | 0.60 |
| BMAL1 | activates | gene | 0.60 |
| Endothelial Cell | expressed_in | cell_type | 0.55 |
| Stem Cell | expressed_in | cell_type | 0.55 |
| BMAL1 | activates | protein | 0.50 |
| ENDOTHELIAL | activates | concept | 0.50 |
| EXTRACELLULAR MATRIX | activates | concept | 0.50 |
| SMAD3 | activates | gene | 0.50 |
| Tgf-Β | activates | pathway | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning adamts4 in their description or question text
No additional research found