protein

DNMT3A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DNMT3A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

288Connections

1Hypotheses

2Analyses

50Outgoing

50Incoming

0Experiments

3Debates

Summary

Page for DNMT3A Protein (DNA Methyltransferase 3A)

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🔬 Protein Info

Gene Symbol	DNMT3A
Full Name	DNA Methyltransferase 3 Alpha
Aliases	DNA Methyltransferase 3A
Chromosome	2p23
Protein Type	Transferase
Function	DNMT3A encodes DNA methyltransferase 3 alpha, a de novo DNA methyltransferase that establishes new DNA methylation patterns during development and in adult tissues.
Primary Expression	neurons during development and in adulthood
Molecular Weight	130 kDa
Pathways	Dna Methylation, Epigenetic
UniProt ID	[Q9Y6K4](https://www.uniprot.org/uniprot/Q9Y6K4)
Ensembl ID	ENSG00000119772
OMIM	602950
GeneCards	DNMT3A
Human Protein Atlas	DNMT3A
Associated Diseases	Als, Alzheimer, Cancer, Cardiovascular, Crohn'S Disease
Known Drugs/Compounds	GEMCITABINE
Interactions	AGING, ALZHEIMER, ALZHEIMER'S DISEASE, AND, ASXL1, BACE1
SciDEX Hypotheses	DNMT3A-Mediated de novo Methylation Corrects 'Epig
KG Connections	288 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

DNMT3A Gene

gene · 715 words

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DNMT3A Protein (DNA Methyltransferase 3A)

protein · 855 words

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Pathway Diagram

graph TD
    DNMT3A["DNMT3A"]
    DNMT3A -->|"target for"| Cancer["Cancer"]
    DNMT3A -->|"target for"| Cardiovascular["Cardiovascular"]
    DNMT3A -->|"activates"| Inflammation["Inflammation"]
    DNMT3A -->|"target for"| Alzheimer["Alzheimer"]
    DNMT3A -->|"target for"| Heart_Failure["Heart Failure"]
    DNMT3A -->|"activates"| Als["Als"]
    DNMT3A -->|"target for"| Leukemia["Leukemia"]
    DNMT3A -->|"expressed in"| Ms["Ms"]
    ASXL1["ASXL1"] -->|"activates"| DNMT3A
    SF3B1["SF3B1"] -->|"activates"| DNMT3A
    TET2["TET2"] -->|"activates"| DNMT3A
    TP53["TP53"] -->|"activates"| DNMT3A
    U2AF1["U2AF1"] -->|"activates"| DNMT3A
    INFLAMMATION["INFLAMMATION"] -->|"activates"| DNMT3A
    TFE3["TFE3"] -->|"regulates"| DNMT3A
    DOT1L["DOT1L"] -->|"regulates"| DNMT3A
    AMPK["AMPK"] -->|"regulates"| DNMT3A
    TFEB["TFEB"] -->|"regulates"| DNMT3A

Outgoing (185)

Target	Relation	Type	Str
Epigenetics	involved_in	process	0.95
Crohn's Disease	risk_factor_for	disease	0.85
Chronic Inflammation	regulates	process	0.85
Crohn'S Disease	associated_with	disease	0.85
Immune Responses	modifies	process	0.80
Immune Response	regulates	process	0.80
Chronic Inflammation	promotes	process	0.80
Leukemia	associated_with	disease	0.80
immune response	modulates	process	0.80
Clonal Hematopoiesis	contributes_to	biological_process	0.80
NEUROINFLAMMATION	regulates	entity	0.75
BRAF	interacts_with	gene	0.75
FOXO3	regulates	gene	0.70
BACE1	inhibits	gene	0.70
DNA_methylation	catalyzes	pathway	0.70
epigenetic regulation	participates_in	pathway	0.70
Heart Failure	therapeutic_target	disease	0.65
Inflammation	expressed_in	disease	0.65
Neuroinflammation	expressed_in	disease	0.65
Autism	expressed_in	disease	0.65
Carcinoma	expressed_in	disease	0.65
Cancer	therapeutic_target	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
Inflammation	activates	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Aging	activates	disease	0.65
neurons	expressed_in	cell_type	0.65
Senescence	activates	disease	0.65
Tumor	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Cardiovascular	associated_with	disease	0.65
Osteoporosis	associated_with	disease	0.65
Heart Failure	associated_with	disease	0.65
Als	activates	disease	0.65
Alzheimer	associated_with	disease	0.65
GEMCITABINE	activates	drug	0.65
ALS	associated_with	disease	0.65
Als	regulates	disease	0.65
Ms	associated_with	disease	0.65
Als	associated_with	disease	0.65
Leukemia	therapeutic_target	disease	0.65
Als	causes	disease	0.65
Inflammation	causes	disease	0.65
Cancer	causes	disease	0.65
Cardiovascular	causes	disease	0.65
Heart Failure	activates	disease	0.65
Ms	expressed_in	disease	0.65
Als	therapeutic_target	disease	0.65
Alzheimer	activates	disease	0.65
Cancer	activates	disease	0.65

Incoming (103)

Source	Relation	Type	Str
h-e5f1182b	targets_gene	hypothesis	0.90
WNT SIGNALING	regulates	pathway	0.70
CREB	protects_against	gene	0.70
DNMT1	stabilizes	gene	0.70
DNMT1	regulates	gene	0.65
DNMT1	associated_with	gene	0.65
FOXO3	targets	gene	0.60
TET2	activates	gene	0.60
TP53	activates	gene	0.60
U2AF1	activates	gene	0.60
TET2	regulates	gene	0.60
TFAM	regulates	gene	0.60
RBPJ	regulates	gene	0.60
CGAS	therapeutic_target	gene	0.60
HDAC10	activates	gene	0.60
HDAC1	activates	gene	0.60
ASXL1	interacts_with	gene	0.60
ASXL1	regulates	gene	0.60
MITOCHONDRIAL DYSFUNCTION	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
RNA	expressed_in	gene	0.60
CREB	targets	gene	0.60
SF3B1	activates	gene	0.60
ASXL1	activates	gene	0.60
TP53	associated_with	gene	0.60
TET2	associated_with	gene	0.60
OCT4	activates	gene	0.60
MYC	activates	gene	0.60
SOX2	activates	gene	0.60
KLF4	activates	gene	0.60
BACH2	implicated_in	gene	0.60
DENND1B	implicated_in	gene	0.60
ASXL1	biomarker_for	gene	0.60
MITOCHONDRIAL DNA	regulates	gene	0.60
FBXW7	therapeutic_target	gene	0.60
AND	regulates	gene	0.60
MITOCHONDRIA	regulates	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
CANCER	therapeutic_target	gene	0.60
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.60
PPM1D	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
C-MYC	activates	gene	0.60
NPM1	associated_with	gene	0.60
AND	activates	gene	0.60
MMP9	regulates	gene	0.60
IL10	regulates	gene	0.60
MMP2	regulates	gene	0.60
PENK	expressed_in	gene	0.60
NCAM1	expressed_in	gene	0.60