concept

CROHN'S DISEASE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CROHN'S DISEASE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

53Connections

0Hypotheses

0Analyses

7Outgoing

46Incoming

0Experiments

0Debates

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💡 Concept Info

Name	CROHN'S DISEASE
Key Genes/Proteins	LRRK2, TNF
Related Diseases	ALZHEIMER'S DISEASE, CANCER, RHEUMATOID ARTHRITIS

Pathway Diagram

graph TD
    CROHN_S_DISEASE["CROHN'S DISEASE"]
    CROHN_S_DISEASE -->|"regulates"| INFLAMMATION["INFLAMMATION"]
    CROHN_S_DISEASE -->|"implicated in"| OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    CROHN_S_DISEASE -->|"regulates"| RHEUMATOID_ARTHRITIS["RHEUMATOID ARTHRITIS"]
    CROHN_S_DISEASE -->|"regulates"| TNF["TNF"]
    TNF_inhibitors["TNF inhibitors"] -->|"treats"| CROHN_S_DISEASE
    PredictSURE_IBD_assay["PredictSURE-IBD assay"] -.biomarker for.-> CROHN_S_DISEASE
    Predictsure_Ibd["Predictsure-Ibd"] -.biomarker for.-> CROHN_S_DISEASE
    Susceptibility_Loci["Susceptibility Loci"] -.biomarker for.-> CROHN_S_DISEASE
    NOD2["NOD2"] -->|"causes"| CROHN_S_DISEASE
    Infliximab["Infliximab"] -->|"treats"| CROHN_S_DISEASE
    Active_inflammation["Active inflammation"] -->|"involved_in"| CROHN_S_DISEASE
    LRRK2["LRRK2"] -->|"risk_factor_for"| CROHN_S_DISEASE

Outgoing (7)

Target	Relation	Type	Str
TNF	interacts_with	gene	0.65
LRRK2	associated_with	gene	0.45
TNF	associated_with	gene	0.45
OXIDATIVE STRESS	implicated_in	process	0.35
INFLAMMATION	regulates	process	0.35
RHEUMATOID ARTHRITIS	regulates	disease	0.35
TNF	regulates	gene	0.35

Incoming (46)

Source	Relation	Type	Str
PredictSURE-IBD assay	biomarker_for	biomarker	0.95
TNF inhibitors	treats	drug	0.95
Predictsure-Ibd	biomarker_for	biomarker	0.95
Susceptibility Loci	biomarker_for	biomarker	0.95
C-Reactive Protein	biomarker_for	biomarker	0.90
LRRK2	risk_factor_for	gene	0.90
Faecal Calprotectin	biomarker_for	biomarker	0.90
Active inflammation	involved_in	phenotype	0.90
Infliximab	treats	drug	0.90
NOD2	causes	gene	0.90
TET1	risk_factor_for	gene	0.90
Faecal calprotectin	biomarker_for	biomarker	0.88
ATG16L1	risk_factor_for	gene	0.88
C-reactive protein	biomarker_for	biomarker	0.88
TYK2	risk_factor_for	gene	0.85
FUT2	risk_factor_for	gene	0.85
DNMT3A	risk_factor_for	gene	0.85
DENND1B	risk_factor_for	gene	0.85
BACH2	risk_factor_for	gene	0.85
TAGAP	risk_factor_for	gene	0.85
T-cell transcriptional signatures	associated_with	biomarker	0.85
SMAD3	risk_factor_for	gene	0.85
ERAP2	risk_factor_for	gene	0.85
IL10	risk_factor_for	gene	0.85
IL2RA	risk_factor_for	gene	0.85
ERAP2	associated_with	gene	0.85
IL10	associated_with	gene	0.85
TYK2	associated_with	gene	0.85
FUT2	associated_with	gene	0.85
DNMT3A	associated_with	gene	0.85
DENND1B	associated_with	gene	0.85
BACH2	associated_with	gene	0.85
TAGAP	associated_with	gene	0.85
IL2RA	associated_with	gene	0.85
Infliximab	treats	drug	0.85
Immunosuppression	treats	process	0.85
Endoscopic Inflammation	associated_with	phenotype	0.85
SMAD3	associated_with	gene	0.85
LRRK2 mutations	causes	phenotype	0.80
CALCOCO2	associated_with	gene	0.70
Xue-Jie-San	treats	drug	0.70
MACROPHAGE	interacts_with	cell_type	0.65
MACROPHAGES	associated_with	cell_type	0.50
ALZHEIMER'S DISEASE	implicated_in	disease	0.35
CANCER	implicated_in	disease	0.35
ALZHEIMER'S DISEASE	interacts_with	disease	0.35

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity