gene

RNA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RNA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

5229Connections

30Hypotheses

11Analyses

50Outgoing

50Incoming

16Experiments

14Debates

Summary

Page for RNA Binding Fox-1 Homolog 2 (RBFOX2)

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	RNA
Aliases	RBFOX2, RBFOX3, RBFOX1
Chromosome	22q12.3
Primary Expression	hippocampus, spinal cord, cortex, cerebellum, prefrontal cortex
Pathways	unfolded protein response, ferroptosis, PI3K-AKT-mTOR signaling, ubiquitin-proteasome, apoptosis pathway
GeneCards	RNA
Human Protein Atlas	RNA
Associated Diseases	aging, Als, Alzheimer, Alzheimer's disease
Known Drugs/Compounds	dimethyl fumarate, ketamine, lecanemab, levodopa, quercetin, rapamycin
Interactions	ABCA7, ABCB1, ACLY, ACTB, Actin, ACVR2A
KG Connections	5227 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    subgraph Pathology["Pathology"]
        RNA["RNA"] -->|"associated with"| astrocytes["astrocytes"]
    end
    subgraph Signaling["Signaling"]
        RNA["RNA"] -->|"activates"| microglia["microglia"]
        RNA["RNA"] -->|"activates"| SQSTM1["SQSTM1"]
        RNA["RNA"] -->|"activates"| neurodegeneration["neurodegeneration"]
        RNA["RNA"] -->|"regulates"| neurodegeneration_1["neurodegeneration"]
        m6A_Modification["m6A Modification"] -->|"modulates"| RNA["RNA"]
        BECN1["BECN1"] -->|"activates"| RNA["RNA"]
        rapamycin["rapamycin"] -->|"activates"| RNA["RNA"]
        rapamycin_3["rapamycin"] -->|"regulates"| RNA["RNA"]
        Stress_Granules["Stress Granules"] -->|"regulates"| RNA["RNA"]
    end
    subgraph Therapeutic["Therapeutic"]
        RNA["RNA"] -->|"expressed in"| hippocampus["hippocampus"]
        RNA["RNA"] -->|"expressed in"| spinal_cord["spinal cord"]
        rapamycin_4["rapamycin"] -->|"targets"| RNA["RNA"]
    end
    subgraph Interactions["Interactions"]
        RNA["RNA"] -->|"participates in"| unfolded_protein_response["unfolded protein response"]
        RNA["RNA"] -->|"interacts with"| neurodegeneration_2["neurodegeneration"]
    end
    style RNA fill:#4a1a6b,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0,font-weight:bold
    style astrocytes fill:#006494,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style microglia fill:#006494,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style hippocampus fill:#90a4ae,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style unfolded_protein_response fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style SQSTM1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style neurodegeneration fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style neurodegeneration_1 fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style spinal_cord fill:#90a4ae,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style neurodegeneration_2 fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style m6A_Modification fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style BECN1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style rapamycin fill:#90a4ae,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style rapamycin_3 fill:#90a4ae,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style rapamycin_4 fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Stress_Granules fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0

Outgoing (2999)

Target	Relation	Type	Str
neurons	activates	cell_type	0.90
aging	associated_with	disease	0.90
frontotemporal dementia	interacts_with	disease	0.90
Alzheimer's disease	regulates	disease	0.90
neurons	expressed_in	cell_type	0.90
PI3K-AKT-mTOR signaling	participates_in	pathway	0.90
microglia	expressed_in	cell_type	0.90
neurons	regulates	cell_type	0.90
ferroptosis	participates_in	pathway	0.90
neural stem cells	regulates	cell_type	0.90
neural stem cells	inhibits	cell_type	0.90
astrocytes	activates	cell_type	0.90
ubiquitin-proteasome	participates_in	pathway	0.90
cortex	expressed_in	brain_region	0.90
microglia	associated_with	cell_type	0.90
neural stem cells	treats	cell_type	0.90
stem cells	expressed_in	cell_type	0.90
mitochondrial function	participates_in	pathway	0.90
T cells	expressed_in	cell_type	0.90
neurons	associated_with	cell_type	0.90
apoptosis pathway	participates_in	pathway	0.90
neurons	interacts_with	cell_type	0.90
neural stem cells	associated_with	cell_type	0.90
hippocampus	expressed_in	brain_region	0.90
neurodegeneration	interacts_with	disease	0.90
SQSTM1	activates	gene	0.90
neural stem cells	interacts_with	cell_type	0.90
neural stem cells	activates	cell_type	0.90
astrocytes	associated_with	cell_type	0.90
microglia	activates	cell_type	0.90
neurodegeneration	activates	disease	0.90
spinal cord	expressed_in	brain_region	0.90
unfolded protein response	participates_in	pathway	0.90
neural stem cells	expressed_in	cell_type	0.90
neurodegeneration	regulates	disease	0.90
DAM microglia	expressed_in	cell_type	0.85
TDP-43	interacts_with	gene	0.85
Neurodegenerative Diseases	biomarker_for	disease	0.85
Frailty	biomarker_for	phenotype	0.85
TDP-43	activates	gene	0.85
TDP-43	regulates	gene	0.85
glioblastoma	expressed_in	disease	0.80
NF-kB signaling	participates_in	pathway	0.80
macrophages	activates	cell_type	0.80
neurons	protects_against	cell_type	0.80
macrophages	inhibits	cell_type	0.80
prefrontal cortex	expressed_in	brain_region	0.80
SYNCRIP	regulates	gene	0.80
Alzheimer's disease	expressed_in	disease	0.80
autophagy pathway	participates_in	pathway	0.80

Incoming (2230)

Source	Relation	Type	Str
Stress Granules	regulates	process	0.90
SETX	binds	protein	0.90
rapamycin	targets	drug	0.90
BECN1	activates	gene	0.90
DNA	associated_with	gene	0.90
TDP43	binds	protein	0.80
ADAR1	activates	gene	0.80
LncRNA	interacts_with	biomarker	0.80
RBFOX3	activates	gene	0.80
ATG	activates	gene	0.80
MAP1LC3B	activates	gene	0.80
ATG	regulates	gene	0.80
GABA	regulates	gene	0.80
LAMP1	activates	gene	0.80
GAPDH	activates	gene	0.80
GABA	activates	gene	0.80
DNA	treats	gene	0.80
GABARAP	regulates	gene	0.80
ALS	accumulates_in	gene	0.80
FUS	causes	gene	0.80
MAP1LC3	regulates	gene	0.80
ACTB	activates	gene	0.80
GABARAP	activates	gene	0.80
BECN1	regulates	gene	0.80
LC3	regulates	gene	0.80
MAP1LC3	activates	gene	0.80
G3BP1	interacts_with	gene	0.75
GAPDH	regulates	gene	0.70
RAN	regulates	gene	0.70
JNK	activates	gene	0.70
LAMP1	regulates	gene	0.70
MTORC1	activates	gene	0.70
AR	activates	gene	0.70
MCOLN1	activates	gene	0.70
MTORC1	regulates	gene	0.70
ATG	interacts_with	gene	0.70
GLA	activates	gene	0.70
FTLD	regulates	gene	0.70
NDP52	regulates	gene	0.70
GFP	regulates	gene	0.70
CALCOCO2	regulates	gene	0.70
ACTB	regulates	gene	0.70
G3BP1	regulates	gene	0.70
FUS	accumulates_in	gene	0.70
GRN	associated_with	gene	0.70
tau protein	interacts_with	protein	0.70
BCL2	regulates	gene	0.70
DNA	accumulates_in	gene	0.70
GBM	activates	gene	0.70
AMPK	regulates	gene	0.70

Targeting Hypotheses (30)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Plasma p-tau217-Triggered Exosome Dosing Maximizes lncRNA-00	0.938	molecular neurobiology	View
Gamma Oscillation Entrainment Enhances lncRNA-9969-Mediated	0.843	molecular neurobiology	View
Calcium-Dysregulated mPTP Opening as an Alternative mtDNA Re	0.804	neurodegeneration	What are the mechanisms by which gut mic
Closed-loop transcranial alternating current stimulation to	0.785	Alzheimer's disease	Circuit-level neural dynamics in neurode
METTL3-Mediated m6A Modification of lncRNA-0021 Regulates mi	0.754	molecular neurobiology	View

Seed-Proximal Asymmetric Duplex Stability Confers lncRNA-002	0.733	molecular neurobiology	View
m6A RNA Modification as Address Code for Granule Targeting	0.700	neurodegeneration	What determines the specificity of RNA-p
Axonal RNA Transport Reconstitution	0.695	neurodegeneration	RNA binding protein dysregulation across
hnRNPA2B1-Mediated Structural Remodeling Controls lncRNA-002	0.684	molecular neurobiology	View
RNA Granule Nucleation Site Modulation	0.662	neurodegeneration	TDP-43 phase separation therapeutics for
Mitochondrial RNA Granule Rescue Pathway	0.656	neurodegeneration	RNA binding protein dysregulation across
Seed match plus local RNA structure jointly determine lncRNA	0.640	molecular neurobiology	How does lncRNA-0021 achieve sequence-sp
H7: Aberrant RNA Template Switching Converts Granules to Agg	0.625	neurodegeneration	How do pathological stress granules tran
Synaptic RNA Metabolism Dysregulation	0.620	neurodegeneration	What mechanisms underlie TDP-43's contri
Trinucleotide Repeat Sequestration via CRISPR-Guided RNA Tar	0.613	neurodegeneration	CRISPR-based therapeutic approaches for
Displacement of G3BP1 RGG Box from Target RNA via Ubiquitin-	0.600	neurodegeneration	How does TRIM21-mediated K63 ubiquitinat
Aβ-induced downregulation of circPDS5B derepresses TDP-43 mR	0.595	neurodegeneration	What mechanisms drive TDP-43 pathology s
Disrupting Muscarinic M1/M3 Receptor-Mediated Tau Internaliz	0.550	neuroscience	Trans-synaptic tau spreading and propaga
RNA Sequence Elements as Primary Specificity Determinants	0.550	neurodegeneration	What determines the specificity of RNA-p
A pre-organized hairpin or loop in lncRNA-0021 creates a hig	0.540	molecular neurobiology	How does lncRNA-0021 achieve sequence-sp
Gamma-Entrained PV Interneurons Enable p-tau217-Guided Preci	0.536	molecular neurobiology	View
Cerebrospinal NFL-Triggered Liposome Dosing Maximizes lncRNA	0.536	molecular neurobiology	View
Gamma-Entrained PV Interneuron Networks Enable Precision p-t	0.536	molecular neurobiology	View
Cerebrospinal Fluid p-tau217-Guided Astrocyte-Derived Extrac	0.536	molecular neurobiology	View
Lipid Nanoparticle Encapsulation of IGFBPL1-mRNA	0.520	drug delivery	Can IGFBPL1 therapeutics effectively cro
Nucleolar p21-rRNA Co-Aggregation as Irreversible Senescence	0.500	molecular biology	What is the optimal therapeutic window t
Structured Intronic Scaffold Regions in Enhancer-dilncRNAs E	0.489	molecular biology	What are the conserved secondary structu
RNA-binding proteins stabilize or gate the lncRNA-0021:mmu-m	0.480	molecular neurobiology	How does lncRNA-0021 achieve sequence-sp
Alpha-Beta Oscillation Coupling Enhances lncRNA-9969-Mediate	0.466	molecular neurobiology	View
RNA-Binding Competition Therapy for TDP-43 Cross-Seeding	0.465	neurodegeneration	Protein aggregation cross-seeding across

Mentioning Analyses (11)

Scientific analyses that reference this entity

Which specific factors in conditioned medium from healthy astrocytes rescue moto

neurodegeneration | 2026-04-25 | 7 hypotheses Top: 0.730

How does lncRNA-0021 achieve sequence-specific binding to mmu-miR-6361 and what

molecular neurobiology | 2026-04-25 | 5 hypotheses Top: 0.640

scRNA-seq Processing and Cell Type Annotation of AD Brain

neurodegeneration | 2026-04-16 | 0 hypotheses

Cas13 gRNA Design for Silencing MAPT (Tau) Transcripts in Alzheimer's Disease

neurodegeneration | 2026-04-16 | 0 hypotheses

RNA binding protein dysregulation across ALS FTD AD

neurodegeneration | 2026-04-13 | 2 hypotheses Top: 0.664

Experiments (16)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
G3BP1-mediated stress granule assembly via liquid-liquid phase separat	exploratory		0.900	0.00	eukaryotic cells	proposed	N/A
G3BP1 intrinsically disordered region analysis and phosphorylation eff	exploratory		0.850	0.00	in vitro protein analysis syst	proposed	N/A
G3BP1-binding factor cooperativity in stress granule network regulatio	exploratory		0.800	0.00	cell culture systems with prot	proposed	N/A
s:** - Temporal analysis showing mitochondrial defects precede other p	falsification	Neurodegeneration	0.400	0.50	cell_line	proposed	$80,000
Proposed experiment from debate on TDP-43 undergoes liquid-liquid phas	falsification	Neurodegeneration	0.400	0.50	cell_line	proposed	$80,000
s:** - Single-cell RNA-seq to measure editing efficiency across differ	falsification	ALS	0.400	0.50	cell_line	proposed	$150,000
ALS Progression Rate Heterogeneity — mechanism and biomarker predictor	clinical	ALS	0.400	0.50	human	proposed	$6,550,000
ALS Regional Onset and Spread: Network-Level Staging Model	clinical	ALS	0.400	0.50	human	proposed	$7,500,000
Sporadic ALS Initiation Biology: Deep Phenotyping of At-Risk Cohorts	clinical	ALS	0.400	0.50	human	proposed	$6,550,000
Axonal Transport Dysfunction Validation in Parkinson's Disease	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$6,550,000
Environmental Exposure Causal Attribution in ALS — Experiment Design	validation	ALS	0.400	0.50	human	proposed	$3,000,000
Frontal and Temporal Lobe Selective Vulnerability in FTD — Mechanisms	validation	Neurodegeneration	0.400	0.50	human	proposed	$3,000,000
FTLD-Tau vs FTLD-TDP In Vivo Biomarker Differentiation	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$6,550,000
C9orf72 Phenotype Divergence: ALS vs FTD Mechanism Study	clinical	ALS	0.400	0.50	human	proposed	$6,550,000
Pre-Symptomatic Detection and Intervention Timing in Genetic Prion Dis	validation	ALS	0.400	0.50	human	proposed	$2,280,000
Stress Granule Dysfunction Validation in Parkinson's Disease	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$5,460,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Stress granule homeostasis is modulated by TRIM21-mediated ubiquitination of G3B [PMID:36692217]	Yang C, Wang Z, Kang Y, Yi Q, Wang T, Ba	Autophagy	2023	3
G3BP1 Is a Tunable Switch that Triggers Phase Separation to Assemble Stress Gran [PMID:32302571]	Yang P, Mathieu C, Kolaitis RM, Zhang P,	Cell	2020	3
Organelle-specific autophagy in inflammatory diseases: a potential therapeutic t [PMID:32048886]	Yao RQ, Ren C, Xia ZF, Yao YM	Autophagy	2021	2
SIRT6-regulated macrophage efferocytosis epigenetically controls inflammation re [PMID:36593966]	Li B, Xin Z, Gao S, Li Y, Guo S, Fu Y, X	Theranostics	2023	1
Role of stress granules in modulating senescence and promoting cancer progressio [PMID:34460104]	Chatterjee D, Chakrabarti O	Int J Cancer	2022	1
Ubiquitination of G3BP1 mediates stress granule disassembly in a context-specifi [PMID:34739333]	Gwon Y, Maxwell BA, Kolaitis RM, Zhang P	Science	2021	1
Multisystem proteinopathy: Where myopathy and motor neuron disease converge. [PMID:33145792]	Korb MK, Kimonis VE, Mozaffar T	Muscle Nerve	2021	1
The role of m6A modification in the biological functions and diseases. [PMID:33611339]	Jiang X, Liu B, Nie Z, Duan L, Xiong Q,	Signal Transduct Target Ther	2021	1
Tumor-derived exosomal miR-934 induces macrophage M2 polarization to promote liv [PMID:33213490]	Senlin Zhao, Yushuai Mi, Bingjie Guan, B	Journal of hematology & oncolo	2020	1
Rare Inherited forms of Paget's Disease and Related Syndromes. [PMID:30756140]	Ralston SH, Taylor JP	Calcif Tissue Int	2019	1
STING is the scaffold protein for stress granule pre-condensation at the ER. [PMID:41917183]	Eom E, Kim J, Kim J, Kang SJ	Cell death and differentiation	2026	0
Stress granules: Guardians of cellular health and triggers of disease. [PMID:39995077]	["Desai M", "Gulati K", "Agrawal M", "Gh	Neural regeneration research	2026	0
A LNK-CBL-HNRPA2B1-GPX4 signaling axis mediates dopaminergic neuron vulnerabilit [PMID:41616574]	["Liu Z", "Wang R", "Shen M", "Lan X", "	Redox biology	2026	0
WFDC21P is essential for G3BP1-mediated RIG-I activation and antitumor immunity [PMID:41915747]	Li Z, Wang Y, Chen Z, Liu R, Lai ZH, Li	Proceedings of the National Ac	2026	0
NUP93 facilitates the nuclear import of SOX2 to activate G3BP1 transcription and [PMID:41896201]	Sun H, Yang C, Du J, Xu C, Chen Y, Chen	Cell death & disease	2026	0
Implications of virus-induced stress granules in tauopathies. [PMID:41673769]	Sharma S, Vandenakker A, Cortés-Pérez C,	Translational neurodegeneratio	2026	0
Human papillomavirus 16 E6 oncoprotein promotes up-regulation of RNA-binding pro [PMID:41725810]	["Cerasuolo A", "Pecchillo Cimmino T", "	Frontiers in microbiology	2026	0
Molecular recognition and induced dimerization of hnRNP A2/B1 truncations by G-q [PMID:41888191]	["Shahatibieke D", "Tang X", "Zheng X",	Scientific reports	2026	0
Evolution of a truncated nucleocapsid protein enhances SARS-CoV-2 fitness by sup [PMID:41920932]	Mulloy RP, Evseev D, Sharlin N, Bui-Mari	PLoS biology	2026	0
PRRC2A, PRRC2B and PRRC2C are Stress Granule Proteins that Promote Translation T [PMID:41808986]	["Huang J", "Kadijk E", "Schreiber K", "	bioRxiv : the preprint server	2026	0

Debates (14)

Multi-agent debates referencing this entity

Which specific factors in conditioned medium from healthy astrocytes rescue moto

active · Rounds: 4 · Score: 0.65 · 2026-04-25

How does lncRNA-0021 achieve sequence-specific binding to mmu-miR-6361 and what

active · Rounds: 4 · Score: 0.66 · 2026-04-25

The ASO therapeutic hypothesis assumes dilncRNAs have targetable conserved struc

closed · Rounds: 4 · Score: 0.69 · 2026-04-21

Can optimized Cas13 guide RNAs selectively silence pathogenic MAPT splice varian

closed · Rounds: 4 · Score: 0.30 · 2026-04-21

Can standardized scRNA-seq processing and automated annotation identify novel ce

closed · Rounds: 4 · Score: 0.30 · 2026-04-21

The debate highlighted that RNA granules serve essential physiological functions

closed · Rounds: 4 · Score: 0.50 · 2026-04-20

Does the hybrid DAM + interferon-response microglial population represent a nove

closed · Rounds: 4 · Score: 0.70 · 2026-04-16

Is Cas13-based 4R-tau silencing feasible given collateral cleavage risks in post

closed · Rounds: 4 · Score: 0.70 · 2026-04-16

RNA binding protein dysregulation across ALS FTD AD

closed · Rounds: 4 · Score: 0.50 · 2026-04-13

RNA binding protein dysregulation across ALS FTD and AD

closed · Rounds: 4 · Score: 0.72 · 2026-04-12

Related Research

Hypotheses and analyses mentioning RNA in their description or question text

Seed-Proximal Asymmetric Duplex Stability Confers lncRNA-0021/miR-6361 Binding S

Score: 0.733 · molecular neurobiology · 2026-04-17

**Molecular Mechanism and Rationale** The lncRNA-0021/miR-6361 interaction represents a sophisticated regulatory mechan

m6A RNA Modification as Address Code for Granule Targeting

Score: 0.700 · neurodegeneration · 2026-04-21

**Molecular Mechanism and Rationale** The N6-methyladenosine (m6A) RNA modification system represents a sophisticated c

Axonal RNA Transport Reconstitution

Score: 0.695 · neurodegeneration · 2026-04-02

## Mechanistic Overview Axonal RNA Transport Reconstitution starts from the claim that modulating HNRNPA2B1 within the d

hnRNPA2B1-Mediated Structural Remodeling Controls lncRNA-0021 Accessibility for

Score: 0.684 · molecular neurobiology · 2026-04-17

## **Molecular Mechanism and Rationale** The proposed therapeutic mechanism centers on the regulatory interplay between

RNA Granule Nucleation Site Modulation

Score: 0.662 · neurodegeneration · 2026-04-02

## Mechanistic Overview RNA Granule Nucleation Site Modulation starts from the claim that modulating G3BP1 within the di

Mitochondrial RNA Granule Rescue Pathway

Score: 0.656 · neurodegeneration · 2026-04-02

## Mechanistic Overview Mitochondrial RNA Granule Rescue Pathway starts from the claim that modulating SYNCRIP within th

Seed match plus local RNA structure jointly determine lncRNA-0021 binding to mmu

Score: 0.640 · molecular neurobiology · 2026-04-25

The most likely explanation is a two-factor recognition mechanism: a canonical miRNA seed-complementary site in lncRNA-0

H7: Aberrant RNA Template Switching Converts Granules to Aggregation Prone

Score: 0.625 · neurodegeneration · 2026-04-22

## Mechanistic Overview H7: Aberrant RNA Template Switching Converts Granules to Aggregation Prone starts from the claim

Synaptic RNA Metabolism Dysregulation

Score: 0.620 · neurodegeneration · 2026-04-21

## Mechanistic Overview Synaptic RNA Metabolism Dysregulation starts from the claim that modulating TARDBP within the di

Trinucleotide Repeat Sequestration via CRISPR-Guided RNA Targeting

Score: 0.613 · neurodegeneration · 2026-04-02

## Mechanistic Overview Trinucleotide Repeat Sequestration via CRISPR-Guided RNA Targeting starts from the claim that mo

Displacement of G3BP1 RGG Box from Target RNA via Ubiquitin-Mediated Allostery

Score: 0.600 · neurodegeneration · 2026-04-21

**Molecular Mechanism and Rationale** The molecular basis for G3BP1-mediated stress granule formation centers on the in

Aβ-induced downregulation of circPDS5B derepresses TDP-43 mRNA translation in li

Score: 0.595 · neurodegeneration · 2026-04-21

**Molecular Mechanism and Rationale** The proposed mechanism centers on a complex regulatory network involving circPDS5

Disrupting Muscarinic M1/M3 Receptor-Mediated Tau Internalization and Synaptic T

Score: 0.550 · neuroscience · 2026-04-22

## Mechanistic Overview Disrupting Muscarinic M1/M3 Receptor-Mediated Tau Internalization and Synaptic Targeting starts

RNA Sequence Elements as Primary Specificity Determinants

Score: 0.550 · neurodegeneration · 2026-04-21

## Mechanistic Overview RNA Sequence Elements as Primary Specificity Determinants starts from the claim that modulating

A pre-organized hairpin or loop in lncRNA-0021 creates a high-affinity docking s

Score: 0.540 · molecular neurobiology · 2026-04-25

lncRNA-0021 may contain a pre-folded structural element that lowers the entropic cost of binding and presents the miR-63

RNA

Understanding Entity Pages

Summary

Wiki Pages (21)

RNA Therapeutics for Neurodegeneration Investment Landscape

RNA Metabolism Dysregulation in Alzheimer's Disease

RNA-Targeted Therapies in Neurodegeneration

ALS RNA Metabolism and Proteostasis Failure

RNASEK — Ribonuclease Kappa

C9orf72→RNA/Dipeptide Repeat Pathology→ALS/FTD — Causal Chain

Non-coding RNAs in Neurodegeneration

RNA Toxicity Pathway

TIAL1 — TIA1 Cytotoxic Granule Associated RNA Binding Protein Like 1

RNA Splicing Defects in Neurodegeneration

RNA Stability and Decay

LARS2 — Leucyl-tRNA Synthetase 2, Mitochondrial

PRPF3 — Pre-mRNA Processing Factor 3

TIA1L (TIA1 Cytotoxic Granule-Associated RNA Binding Protein-Like)

RNA Targeting Therapy for Neurodegeneration

RNA Processing in Neurodegeneration

mRNA-Encoded Intrabody for Alpha-Synuclein Clearance

C9orf72 RNA-Targeting Dipeptide Repeat Reduction

RNA Metabolism in Neurodegeneration

RNASEH1 — Ribonuclease H1

AD RNA-Based Therapeutics Companies

Pathway Diagram

Outgoing (2999)

Incoming (2230)

Targeting Hypotheses (30)

Mentioning Analyses (11)

Which specific factors in conditioned medium from healthy astrocytes rescue moto

How does lncRNA-0021 achieve sequence-specific binding to mmu-miR-6361 and what

scRNA-seq Processing and Cell Type Annotation of AD Brain

Cas13 gRNA Design for Silencing MAPT (Tau) Transcripts in Alzheimer's Disease

RNA binding protein dysregulation across ALS FTD AD

Do chronic stress granule inhibition strategies impair normal cellular stress re

What are the conserved secondary structures in dilncRNAs that enable selective t

What determines the specificity of DDR protein recruitment to dilncRNA-induced c

How do dilncRNAs specifically drive molecular crowding and phase separation of D

Extracellular vesicle biomarkers for early AD detection

RNA binding protein dysregulation across ALS FTD and AD

Experiments (16)

Related Papers (20)

Debates (14)

Which specific factors in conditioned medium from healthy astrocytes rescue moto

How does lncRNA-0021 achieve sequence-specific binding to mmu-miR-6361 and what

The ASO therapeutic hypothesis assumes dilncRNAs have targetable conserved struc

Can optimized Cas13 guide RNAs selectively silence pathogenic MAPT splice varian

Can standardized scRNA-seq processing and automated annotation identify novel ce

The debate highlighted that RNA granules serve essential physiological functions

Does the hybrid DAM + interferon-response microglial population represent a nove

Is Cas13-based 4R-tau silencing feasible given collateral cleavage risks in post

RNA binding protein dysregulation across ALS FTD AD

RNA binding protein dysregulation across ALS FTD and AD

Related Research

Seed-Proximal Asymmetric Duplex Stability Confers lncRNA-0021/miR-6361 Binding S

m6A RNA Modification as Address Code for Granule Targeting

Axonal RNA Transport Reconstitution

hnRNPA2B1-Mediated Structural Remodeling Controls lncRNA-0021 Accessibility for

RNA Granule Nucleation Site Modulation

Mitochondrial RNA Granule Rescue Pathway

Seed match plus local RNA structure jointly determine lncRNA-0021 binding to mmu

H7: Aberrant RNA Template Switching Converts Granules to Aggregation Prone

Synaptic RNA Metabolism Dysregulation

Trinucleotide Repeat Sequestration via CRISPR-Guided RNA Targeting

Displacement of G3BP1 RGG Box from Target RNA via Ubiquitin-Mediated Allostery

Aβ-induced downregulation of circPDS5B derepresses TDP-43 mRNA translation in li

Disrupting Muscarinic M1/M3 Receptor-Mediated Tau Internalization and Synaptic T

RNA Sequence Elements as Primary Specificity Determinants

A pre-organized hairpin or loop in lncRNA-0021 creates a high-affinity docking s