gene

RBFOX3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RBFOX3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

57Connections

0Hypotheses

0Analyses

9Outgoing

48Incoming

0Experiments

0Debates

Summary

RNA Binding Fox-3 Homolog (NeuN) (RBFOX3)

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	RBFOX3
Full Name	RNA Binding Fox-3 Homolog (NeuN) (RBFOX3)
Aliases	RNA Binding Protein Fox-3
Chromosome	17q21.31
Protein Type	Gene
Function	Nuclear Localization: Predominantly localizes to the nucleus of most post-mitotic neurons.
Primary Expression	nearly all neurons in the central and peripheral nervous system
Subcellular Localization	, providing additional layers of control over RBFOX3 activity
UniProt ID	Q8WWI5
NCBI Gene ID	22998
Ensembl ID	ENSG00000161981
GeneCards	RBFOX3
Human Protein Atlas	RBFOX3
Associated Diseases	Rett Syndrome, Intellectual Disability, Epilepsy, Autism Spectrum Disorder
Known Drugs/Compounds	rapamycin
Interactions	ACTB, AIF1, AMPK, ARC, ATF6, ATG
KG Connections	57 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: RBFOX3 — AlphaFold Q8WWI5 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

RNA Binding Fox-3 Homolog (NeuN) (RBFOX3)

gene · 1010 words

→

RBFOX3/NeuN Protein

protein · 998 words

→

Pathway Diagram

flowchart TD
    N0["RBFOX3"]
    N1["AIF1"]
    N1 -->|"activates"| N0
    N2["AMPK"]
    N2 -->|"activates"| N0
    N3["ARC"]
    N3 -->|"activates"| N0
    N4["CAMKK2"]
    N4 -->|"activates"| N0
    N5["COX4I1"]
    N5 -->|"activates"| N0
    N6["GFAP"]
    N6 -->|"activates"| N0
    N7["IBA1"]
    N7 -->|"activates"| N0
    N8["LAMP2"]
    N8 -->|"activates"| N0
    N9["RNA"]
    N0 -->|"activates"| N9
    N10["autophagy pathway"]
    N0 -->|"participates in"| N10
    N11["ubiquitin-proteasome"]
    N0 -->|"participates in"| N11
    N12["Alzheimer's disease"]
    N0 -->|"activates"| N12
    N13["neurodegeneration"]
    N0 -->|"activates"| N13
    N14["WDR45"]
    N0 -->|"activates"| N14
    N15["traumatic brain injury"]
    N0 -->|"activates"| N15
    N16["autism spectrum disorder"]
    N0 -->|"activates"| N16

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    classDef drug fill:#1a2a2a,stroke:#26c6da,color:#e0e0e0
    classDef cell_type fill:#2a1a2a,stroke:#ab47bc,color:#e0e0e0
    classDef phenotype fill:#2a2a1a,stroke:#ffa726,color:#e0e0e0
    classDef process fill:#1a2a2a,stroke:#66bb6a,color:#e0e0e0
    classDef biological_process fill:#1a2a2a,stroke:#66bb6a,color:#e0e0e0
    classDef concept fill:#1a1a2a,stroke:#7986cb,color:#e0e0e0
    classDef entity fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef therapeutic fill:#1a2a2a,stroke:#26c6da,color:#e0e0e0
    classDef index fill:#1a1a2a,stroke:#7986cb,color:#e0e0e0
    class N0 gene
    class N1 gene
    class N2 gene
    class N3 gene
    class N4 gene
    class N5 gene
    class N6 gene
    class N7 gene
    class N8 gene
    class N9 gene
    class N10 pathway
    class N11 pathway
    class N12 disease
    class N13 disease
    class N14 gene
    class N15 disease
    class N16 disease

Outgoing (9)

Target	Relation	Type	Str
RNA	activates	gene	0.80
traumatic brain injury	activates	disease	0.60
WDR45	activates	gene	0.60
Alzheimer's disease	activates	disease	0.60
autism spectrum disorder	activates	disease	0.60
neurodegeneration	activates	disease	0.60
autophagy pathway	participates_in	pathway	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
neurons	expressed_in	cell_type	0.55

Incoming (48)

Source	Relation	Type	Str
GFP	activates	gene	0.60
MAP1LC3	activates	gene	0.60
ATG	activates	gene	0.60
rapamycin	targets	drug	0.60
FTLD	associated_with	gene	0.60
AIF1	activates	gene	0.60
ARC	activates	gene	0.60
CAMKK2	activates	gene	0.60
COX4I1	activates	gene	0.60
GFAP	activates	gene	0.60
IBA1	activates	gene	0.60
LAMP2	activates	gene	0.60
CNP	associated_with	gene	0.60
NEFL	associated_with	gene	0.60
NPTX1	associated_with	gene	0.60
CCL25	associated_with	gene	0.60
MMP1	associated_with	gene	0.60
AMPK	activates	gene	0.60
LC3B	activates	gene	0.60
DNA	activates	gene	0.60
ACTB	activates	gene	0.60
ATG12	activates	gene	0.60
ATG5	activates	gene	0.60
ATG7	activates	gene	0.60
BECN1	activates	gene	0.60
CTSD	activates	gene	0.60
CTSL	activates	gene	0.60
LAMP1	activates	gene	0.60
LC3	activates	gene	0.60
NAGLU	activates	gene	0.60
PLA2G4A	activates	gene	0.60
ATF6	activates	gene	0.60
CHOP	activates	gene	0.60
DDIT3	activates	gene	0.60
EIF2A	activates	gene	0.60
EIF2AK3	activates	gene	0.60
ERN1	activates	gene	0.60
HSP70	activates	gene	0.60
HSPA5	activates	gene	0.60
IRE1	activates	gene	0.60
MTOR	activates	gene	0.60
PERK	activates	gene	0.60
MAP1LC3B	activates	gene	0.60
NEFM	activates	gene	0.60
NFM	activates	gene	0.60
NPY	activates	gene	0.60
POMC	activates	gene	0.60
PRKN	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning RBFOX3 in their description or question text

No additional research found