| Gene Symbol | RNASEH1 |
| Full Name | Ribonuclease H1 |
| Chromosome | 2p25.1 |
| Protein Type | Enzyme |
| Function | encodes an essential enzyme that cleaves RNA within RNA-DNA hybrids, playing critical roles in DNA replication, repair, and transcription. |
| Primary Expression | all major brain cell types, with particularly high expression in neurons: |
| Amino Acids | 282 aa |
| UniProt ID | Q9UQ10 |
| NCBI Gene ID | 246246 |
| Ensembl ID | ENSG00000131845 |
| GeneCards | RNASEH1 |
| Human Protein Atlas | RNASEH1 |
| Astrocytes | moderate expression, supporting these cells' roles in metabolic support and neurotransmitter homeostasis. Astrocyte RNASEH1 may also contribute to brain-wide R-loop management. |
| Oligodendrocytes | important for myelin maintenance, which requires ongoing protein synthesis and membrane production. RNASEH1 supports the high metabolic demands of oligodendrocyte function. |
| Microglia | expression increases in response to neuroinflammation, suggesting roles in the DNA damage response that accompanies microglial activation. |
| Associated Diseases | Als, Breast Cancer, Cancer, Tumor |
| KG Connections | 26 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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