concept

KETAMINE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about KETAMINE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

85Connections

0Hypotheses

0Analyses

50Outgoing

18Incoming

0Experiments

0Debates

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💡 Concept Info

Name	KETAMINE
Key Genes/Proteins	BDNF, CREB, CSF1R, ERK
Related Diseases	ANXIETY, BBB, BIPOLAR DISORDER, BLOOD-BRAIN BARRIER, DEPRESSION

Pathway Diagram

graph TD
    KETAMINE["KETAMINE"]
    KETAMINE -->|"treats"| Depression["Depression"]
    KETAMINE -->|"treats"| rapid_antidepressant_response["rapid antidepressant response"]
    KETAMINE -->|"inhibits"| NMDAR["NMDAR"]
    KETAMINE -->|"upregulates"| BDNF["BDNF"]
    KETAMINE -->|"activates"| ERK["ERK"]
    KETAMINE -->|"treats"| acute_kidney_injury["acute kidney injury"]
    KETAMINE -->|"targets"| GABAergic_Interneurons["GABAergic Interneurons"]
    KETAMINE -->|"treats"| Treatment_Resistant_Depression["Treatment-Resistant Depression"]
    BDNF -->|"mediates"| KETAMINE
    CSF1R["CSF1R"] -->|"inhibits"| KETAMINE

Outgoing (67)

Target	Relation	Type	Str
Depression	treats	disease	0.95
depression	treats	disease	0.90
NMDAR	inhibits	receptor	0.90
BDNF	upregulates	protein	0.90
rapid antidepressant response	treats	phenotype	0.90
hyperarousal	inhibits	phenotype	0.85
Post-Traumatic Stress Disorder	treats	disease	0.85
acute kidney injury	treats	disease	0.85
ERK	activates	protein	0.85
Neuroplasticity	associated_with	process	0.85
Treatment-Resistant Depression	treats	disease	0.85
GABAergic Interneurons	targets	cell_type	0.85
NPY	upregulates	gene	0.80
HCN1	downregulates	gene	0.80
anxiety	treats	disease	0.70
BDNF	regulates	gene	0.70
CA1	activates	brain_region	0.70
c-Fos	activates	gene	0.70
BDNF	associated_with	gene	0.70
unfolded protein response	modulates	pathway	0.70
GPR109A	treats	gene	0.70
BDNF	activates	protein	0.68
BDNF	interacts_with	gene	0.65
DEPRESSION	causes	disease	0.65
DEPRESSION	activates	disease	0.65
ANXIETY	interacts_with	disease	0.65
ANXIETY	targets	disease	0.65
GLUTAMATE	activates	phenotype	0.65
CA1	regulates	brain_region	0.65
BDNF	regulates	gene	0.65
ANTIDEPRESSANT	associated_with	drug	0.64
CREB	inhibits	gene	0.60
DNA	inhibits	gene	0.60
RNA	inhibits	gene	0.60
CREB	regulates	gene	0.60
ERK	regulates	gene	0.60
CREB	activates	gene	0.60
CREB	associated_with	gene	0.60
ERK	associated_with	gene	0.60
PTSD	treats	disease	0.60
HCN1	activates	gene	0.60
HCN1	expressed_in	gene	0.60
HCN1	regulates	gene	0.60
HCN1	implicated_in	gene	0.60
GPR109A	implicated_in	gene	0.60
GPR109A	biomarker_for	gene	0.60
GPR109A	expressed_in	gene	0.60
schizophrenia	treats	disease	0.60
BDNF	interacts_with	gene	0.60
DEPRESSION	stabilizes	disease	0.60

Incoming (18)

Source	Relation	Type	Str
BDNF	mediates	protein	0.88
CSF1R	inhibits	gene	0.65
BDNF	inhibits	gene	0.65
BDNF	stabilizes	gene	0.60
INFLAMMATION	associated_with	phenotype	0.45
HIPPOCAMPUS	associated_with	brain_region	0.45
GLUTAMATE	associated_with	phenotype	0.45
DEPRESSION	associated_with	disease	0.45
BDNF	associated_with	gene	0.45
ANXIETY	associated_with	disease	0.45
CREB	associated_with	gene	0.45
ERK	associated_with	gene	0.45
CSF1R	associated_with	gene	0.45
BLOOD-BRAIN BARRIER	associated_with	phenotype	0.45
BBB	associated_with	phenotype	0.45
FLUOXETINE	associated_with	drug	0.45
BIPOLAR DISORDER	associated_with	disease	0.45
MICROGLIA	associated_with	cell_type	0.45

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning KETAMINE in their description or question text

No additional research found