concept

LECANEMAB

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LECANEMAB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

111Connections

0Hypotheses

1Analyses

50Outgoing

37Incoming

0Experiments

1Debates

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💡 Concept Info

Name	LECANEMAB
Key Genes/Proteins	AMYLOID, AMYLOID-BETA, APOE, APOE4, APP, BACE1
Related Diseases	AGING, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID PLAQUES, AUTOPHAGY

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Lecanemab CLARITY Open-Label Extension

clinical · 2301 words

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Pathway Diagram

graph TD
    LECANEMAB["LECANEMAB"]
    LECANEMAB -->|"treats"| Cognitive_Decline["Cognitive Decline"]
    LECANEMAB -->|"targets"| Amyloid_Beta["Amyloid Beta"]
    LECANEMAB -->|"targets"| Amyloid__["Amyloid-beta"]
    LECANEMAB -->|"targets"| AMYLOID_BETA["AMYLOID-BETA"]
    LECANEMAB -->|"treats"| Early_Stage_Alzheimer_s_Diseas["Early-Stage Alzheimer's Disease"]
    LECANEMAB -->|"targets"| Brain_Amyloid_Pathology["Brain Amyloid Pathology"]
    LECANEMAB -->|"targets"| Amyloid_Pathology["Amyloid Pathology"]
    Anticoagulation["Anticoagulation"] -->|"interacts"| LECANEMAB
    DONANEMAB["DONANEMAB"] -->|"target for"| LECANEMAB
    ADUCANUMAB["ADUCANUMAB"] -->|"target for"| LECANEMAB
    Amyloid["Amyloid"] -->|"interacts"| LECANEMAB
    AMYLOID["AMYLOID"] -->|"target for"| LECANEMAB
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"target for"| LECANEMAB

Outgoing (74)

Target	Relation	Type	Str
ad_clinical_trial_failures:lecanemab	data_in	dataset_row	0.00
ad_clinical_trial_failures:lecanemab	data_in	dataset_row	0.00
Cognitive Decline	treats	phenotype	0.95
Amyloid-Β	targets	protein	0.95
Amyloid β	targets	protein	0.95
Amyloid-β	targets	protein	0.95
amyloid-β	targets	compound	0.92
Aβ accumulation	therapeutic_target_for	mechanism	0.90
Alzheimer disease	therapeutic_target_for	disease	0.90
Alzheimer'S Disease	treats	disease	0.90
Amyloid Pathology	targets	mechanism	0.90
amyloid pathology	inhibits	mechanism	0.90
AMYLOID-BETA	targets	protein	0.90
Brain Amyloid Pathology	targets	biomarker	0.90
Amyloid-Beta	targets	protein	0.90
Early-Stage Alzheimer's Disease	treats	disease	0.90
Amyloid Related Imaging Abnormalities	causes	phenotype	0.85
Amyloid-Beta Clearance	associated_with	process	0.85
Alzheimer's Disease	treats	disease	0.85
ALZHEIMER'S DISEASE	treats	disease	0.85
Microhemorrhages	causes	phenotype	0.80
ubiquitin-proteasome	modulates	pathway	0.75
Infusion Reactions	causes	phenotype	0.75
Macrohemorrhages	causes	phenotype	0.75
Alzheimer's Disease	treats	disease	0.75
neuroinflammation	treats	disease	0.75
cognitive decline	modulates	phenotype	0.70
Amyloid	activates	pathway	0.70
Amyloid	inhibits	pathway	0.70
Amyloid	interacts_with	pathway	0.70
Alzheimer's disease	treats	disease	0.70
neurotrophin signaling	modulates	pathway	0.65
blood-brain barrier	modulates	pathway	0.65
ALZHEIMER'S DISEASE	interacts_with	disease	0.65
AMYLOID	regulates	protein	0.65
neurodegeneration	treats	disease	0.65
AMYLOID PLAQUES	causes	phenotype	0.65
autophagy pathway	modulates	pathway	0.65
ALZHEIMER'S DISEASE	activates	disease	0.65
RNA	targets	gene	0.60
APOE	targets	gene	0.60
APOE4	targets	gene	0.60
multiple sclerosis	treats	disease	0.60
NEURON	associated_with	cell_type	0.60
NEURON	stabilizes	cell_type	0.60
BDNF	targets	gene	0.55
insulin signaling	modulates	pathway	0.55
BACE1	targets	gene	0.55
NGF	targets	gene	0.55
TREM2	targets	gene	0.55

Incoming (37)

Source	Relation	Type	Str
ad_clinical_trial_failures:lecanemab	data_in	dataset_row	0.00
ad_clinical_trial_failures:lecanemab	data_in	dataset_row	0.00
36544184	slows	paper	0.90
36544184	targets	paper	0.90
36544184	reduces	paper	0.90
DONANEMAB	therapeutic_target	drug	0.80
ADUCANUMAB	targets	drug	0.80
Anticoagulation	interacts_with	process	0.80
Amyloid	interacts_with	entity	0.70
AMYLOID	therapeutic_target	protein	0.65
ALZHEIMER	treats	disease	0.65
ALZHEIMER'S DISEASE	treats	disease	0.65
DEMENTIA	treats	disease	0.65
NEUROINFLAMMATION	associated_with	phenotype	0.50
MITOCHONDRIAL DYSFUNCTION	associated_with	phenotype	0.50
PROTEIN AGGREGATION	associated_with	phenotype	0.50
PROTEOSTASIS	associated_with	phenotype	0.50
AMYLOID-BETA	associated_with	protein	0.50
ALZHEIMER'S DISEASE	therapeutic_target	disease	0.50
NEURODEGENERATION	associated_with	phenotype	0.50
INFLAMMATION	associated_with	phenotype	0.50
MULTIPLE SCLEROSIS	associated_with	disease	0.45
AMYLOID PLAQUES	associated_with	phenotype	0.45
COGNITIVE DECLINE	associated_with	phenotype	0.45
ADUCANUMAB	associated_with	drug	0.45
DONANEMAB	associated_with	drug	0.45
AMYLOID	associated_with	protein	0.45
GANTENERUMAB	associated_with	drug	0.45
SOLANEZUMAB	associated_with	drug	0.45
CRENEZUMAB	associated_with	drug	0.45
ALZHEIMER	associated_with	disease	0.45
DEMENTIA	associated_with	disease	0.45
APOE	associated_with	gene	0.45
CEREBRAL AMYLOID ANGIOPATHY	associated_with	disease	0.45
ALZHEIMER'S DISEASE	associated_with	disease	0.35
DEMENTIA	therapeutic_target	disease	0.35
APOE	therapeutic_target	gene	0.35

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Why have numerous phase 3 clinical trials failed despite advances in understandi

neurodegeneration | 2026-04-12 | 1 hypotheses Top: 0.566

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

Why have numerous phase 3 clinical trials failed despite advances in understandi

closed · Rounds: 5 · Score: 0.67 · 2026-04-12

Related Research

Hypotheses and analyses mentioning LECANEMAB in their description or question text

No additional research found