concept

PIKFYVE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PIKFYVE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

136Connections

2Hypotheses

1Analyses

50Outgoing

50Incoming

1Experiments

1Debates

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💡 Concept Info

Name	PIKFYVE
Key Genes/Proteins	ACTB, AMPK, amyotrophic lateral sclerosis, AND, App, C9ORF72
Related Diseases	Als, Amyotrophic Lateral Sclerosis, AMYOTROPHIC LATERAL SCLEROSIS
Related Pathways	Autophagy, autophagy pathway
Linked Hypotheses	2 hypotheses

Pathway Diagram

graph TD
    PIKFYVE["PIKFYVE"]
    PIKFYVE -->|"targets"| ALS["ALS"]
    PIKFYVE -->|"regulates"| MCOLN1["MCOLN1"]
    PIKFYVE -->|"produces"| PtdIns_3_5_P2["PtdIns(3,5)P2"]
    PIKFYVE -->|"involved_in"| Motor_Neuron_Degeneration["Motor Neuron Degeneration"]
    PIKFYVE -->|"inhibits"| Als["Als"]
    PIKFYVE -->|"inhibits"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    PIKFYVE -->|"inhibits"| Ms["Ms"]
    PIKFYVE -->|"activates"| Parkinson["Parkinson"]
    AMPK["AMPK"] -->|"activates"| PIKFYVE
    C9ORF72["C9ORF72"] -->|"inhibits"| PIKFYVE
    ALS -->|"inhibits"| PIKFYVE
    GABARAP["GABARAP"] -->|"activates"| PIKFYVE
    FUS["FUS"] -->|"inhibits"| PIKFYVE
    ENDOSOMES["ENDOSOMES"] -->|"activates"| PIKFYVE
    PTEN["PTEN"] -->|"activates"| PIKFYVE
    MOTOR_NEURONS["MOTOR NEURONS"] -->|"inhibits"| PIKFYVE
    UBIQUITIN["UBIQUITIN"] -->|"inhibits"| PIKFYVE
    TARDBP["TARDBP"] -->|"inhibits"| PIKFYVE

Outgoing (83)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:PIKFYVE	data_in	dataset_row	0.00
h-9025d807	targeted_by	hypothesis	1.00
h-b3e97952	targeted_by	hypothesis	1.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
ALS	targets	entity	0.95
Disease Progression	inhibits	phenotype	0.90
ALS	mitigates	disease	0.90
PtdIns(3,5)P2	produces	protein	0.90
MCOLN1	regulates	gene	0.90
LRRK2	regulates	protein	0.85
ALS	implicated_in	disease	0.80
AMYOTROPHIC LATERAL SCLEROSIS	causes	disease	0.80
Motor Neuron Degeneration	involved_in	process	0.80
Protein Clearance	activates	pathway	0.80
endosomal-lysosomal pathway	involved_in	pathway	0.80
motor neuron	expressed_in	cell_type	0.75
Als	inhibits	disease	0.75
Amyotrophic Lateral Sclerosis	inhibits	disease	0.75
Neuronal Function	regulates	process	0.75
neurons	expressed_in	cell_type	0.70
AUTOPHAGY	regulates	process	0.70
Melanoma	activates	disease	0.65
Parkinson	activates	disease	0.65
Ms	activates	disease	0.65
Dementia	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Als	activates	disease	0.65
Tumor	activates	disease	0.65
Amyotrophic Lateral Sclerosis	therapeutic_target	disease	0.65
Frontotemporal Dementia	activates	disease	0.65
ALS	activates	disease	0.65
Ms	inhibits	disease	0.65
Amyotrophic Lateral Sclerosis	treats	disease	0.65
Amyotrophic Lateral Sclerosis	protects_against	disease	0.65
Autophagy	protects_against	pathway	0.60
Stem Cell	protects_against	cell_type	0.60
UBIQUITIN	inhibits	gene	0.60
MOTOR NEURONS	inhibits	gene	0.60
FUS	inhibits	gene	0.60
TARDBP	inhibits	gene	0.60
Exocytosis	activates	pathway	0.60
Autophagy	therapeutic_target	pathway	0.60
Autophagy	inhibits	pathway	0.60
MET	activates	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	inhibits	gene	0.60
Stem Cell	activates	pathway	0.60
Tdp-43	inhibits	pathway	0.60
AND	inhibits	gene	0.60
RNA	activates	gene	0.60
AND	activates	gene	0.60

Incoming (53)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:PIKFYVE	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00
h-9025d807	targets	hypothesis	1.00
h-b3e97952	targets	hypothesis	1.00
Apilimod Dimesylate	inhibits	drug	0.95
AMPK	activates	protein	0.80
C9ORF72	inhibits	gene	0.70
ALS	inhibits	gene	0.70
TARDBP	inhibits	gene	0.60
ALS	protects_against	gene	0.60
C9ORF72	protects_against	gene	0.60
FUS	protects_against	gene	0.60
FUS	inhibits	gene	0.60
AND	inhibits	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	inhibits	gene	0.60
DEMENTIA	activates	gene	0.60
UBIQUITIN	inhibits	gene	0.60
TAU	activates	gene	0.60
ELAVL4	activates	gene	0.60
MAPT	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
MCOLN1	activates	gene	0.60
MTORC1	activates	gene	0.60
rapamycin	targets	drug	0.60
GABARAP	activates	gene	0.60
MOTOR NEURONS	inhibits	gene	0.60
NEURODEGENERATION	activates	gene	0.60
NEURON	inhibits	gene	0.60
ACTB	activates	gene	0.60
CTSB	activates	gene	0.60
CTSD	activates	gene	0.60
EIF4EBP1	activates	gene	0.60
GFP	activates	gene	0.60
GUSB	activates	gene	0.60
HEXB	activates	gene	0.60
LC3	activates	gene	0.60
LDL	activates	gene	0.60
LGALS3	activates	gene	0.60
LRP2	activates	gene	0.60
MAP1LC3	activates	gene	0.60
PTEN	activates	gene	0.60
CRLS1	activates	gene	0.60
ENDOSOMES	activates	gene	0.60
UBIQUITIN	treats	gene	0.60
Neuron	inhibits	cell_type	0.50
GLUTAMATE	inhibits	concept	0.50
disease	inhibits	disease	0.50
Melanoma	activates	disease	0.50
Exocytosis	activates	pathway	0.50
disease	activates	disease	0.50

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
PIKFYVE Inhibition Activates Aggregate Exocytosis via PI(3,5	0.584	neurodegeneration	How does PIKFYVE inhibition activate unc
C9orf72-SMCR8-WDR41 Complex Dysfunction in C9-ALS Rescued by	0.562	neurodegeneration	How does PIKFYVE inhibition activate unc

Mentioning Analyses (1)

Scientific analyses that reference this entity

How does PIKFYVE inhibition activate unconventional protein clearance via exocyt

neurodegeneration | 2026-04-13 | 2 hypotheses Top: 0.584

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
PPP3/calcineurin-dependent TFEB dephosphorylation mechanism	exploratory	motoneuron degeneration	0.800	0.00	neuronal cell lines	proposed	N/A

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

How does PIKFYVE inhibition activate unconventional protein clearance via exocyt

closed · Rounds: 4 · Score: 0.63 · 2026-04-13

Related Research

Hypotheses and analyses mentioning PIKFYVE in their description or question text

No additional research found