concept

LDL

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LDL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

782Connections

4Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

LDL is a concept in neurodegeneration research. Key relationships include: inhibits, activates, associated with. Associated with AD, ALI, ALS. Connected to 342 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	LDL
Key Genes/Proteins	ABCA1, ABCG1, ACACA, ACC, ACE, ACETYL-COA
Related Diseases	AD, Aging
Linked Hypotheses	4 hypotheses

Wiki Pages (9)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    LDL["LDL"]
    LDL -->|"inhibits"| Atherosclerosis["Atherosclerosis"]
    LDL -->|"activates"| ALS["ALS"]
    LDL -->|"inhibits"| Inflammation["Inflammation"]
    LDL -->|"inhibits"| Cardiovascular["Cardiovascular"]
    LDL -->|"interacts"| AMPK["AMPK"]
    LDL -->|"interacts"| ACTB["ACTB"]
    LDLR["LDLR"] -->|"regulates"| LDL
    ABCA1["ABCA1"] -->|"interacts"| LDL
    MTOR["MTOR"] -->|"inhibits"| LDL
    P62["P62"] -->|"interacts"| LDL
    LC3["LC3"] -->|"interacts"| LDL
    APOE["APOE"] -->|"inhibits"| LDL
    SQSTM1["SQSTM1"] -->|"interacts"| LDL
    GAIN["GAIN"] -->|"inhibits"| LDL
    PCSK9["PCSK9"] -->|"inhibits"| LDL

Outgoing (493)

Target	Relation	Type	Str
Atherosclerosis	inhibits	disease	1.00
APOE	inhibits	gene	1.00
Atherosclerosis	activates	disease	1.00
Als	inhibits	disease	1.00
Inflammation	activates	disease	0.95
Inflammation	inhibits	disease	0.95
oxidative stress response	participates_in	pathway	0.90
Cholesterol	associated_with	pathway	0.90
Cholesterol	inhibits	pathway	0.90
Lipid Metabolism	activates	pathway	0.90
Cholesterol	activates	pathway	0.90
Atherosclerosis	regulates	disease	0.85
Cardiovascular	regulates	disease	0.85
Cardiovascular	inhibits	disease	0.85
Aging	associated_with	disease	0.85
Myocardial Infarction	associated_with	disease	0.85
Als	associated_with	disease	0.85
ceramide	interacts_with	compound	0.80
macrophages	expressed_in	cell_type	0.80
Ceramide	transports	compound	0.80
unfolded protein response	participates_in	pathway	0.80
spinal muscular atrophy	associated_with	disease	0.80
GENES	associated_with	gene	0.80
APOE	associated_with	gene	0.80
Nf-Κb	inhibits	pathway	0.80
APOE	activates	gene	0.80
Atherosclerosis	associated_with	disease	0.75
Cardiovascular	associated_with	disease	0.75
Als	treats	disease	0.75
Fatty Liver	activates	disease	0.75
Tumor	inhibits	disease	0.75
Inflammation	treats	disease	0.75
Nafld	activates	disease	0.75
Stroke	associated_with	disease	0.75
Inflammation	associated_with	disease	0.75
Coronary Artery Disease	associated_with	disease	0.75
Fibrosis	inhibits	disease	0.75
Stroke	inhibits	disease	0.75
Cardiovascular	protects_against	disease	0.75
neural stem cells	activates	cell_type	0.70
autophagy pathway	participates_in	pathway	0.70
AMPK signaling	participates_in	pathway	0.70
SREBP2	regulates	gene	0.70
Mtor	inhibits	pathway	0.70
Cholesterol	regulates	pathway	0.70
PCSK9	regulates	gene	0.70
lipid metabolism	participates_in	pathway	0.70
AKT	inhibits	gene	0.70
Lipid Metabolism	regulates	pathway	0.70
MTOR	inhibits	gene	0.70

Incoming (289)

Source	Relation	Type	Str
LDLR	regulates	protein	0.97
INFLAMMATION	activates	gene	0.80
PCSK9	inhibits	gene	0.70
ABCA1	activates	gene	0.70
INFLAMMATION	associated_with	gene	0.70
TNF-Α	inhibits	gene	0.70
LDLR	associated_with	gene	0.70
LDLR	activates	gene	0.70
PI3K	activates	gene	0.70
IL-6	associated_with	gene	0.70
TNF	inhibits	gene	0.70
STROKE	associated_with	gene	0.70
statins	activates	compound	0.70
INFLAMMATION	inhibits	gene	0.70
NF-ΚB	inhibits	gene	0.70
APOE	interacts_with	gene	0.65
CD14	associated_with	gene	0.60
PECAM1	associated_with	gene	0.60
STROKE	treats	gene	0.60
CANCER	treats	gene	0.60
TNF	associated_with	gene	0.60
PI3K	regulates	gene	0.60
NF-ΚB	regulates	gene	0.60
VEGF	associated_with	gene	0.60
VCAM1	associated_with	gene	0.60
TNF-Α	associated_with	gene	0.60
NEURODEGENERATIVE DISORDERS	interacts_with	gene	0.60
ALZHEIMER'S DISEASE	interacts_with	gene	0.60
AND	activates	gene	0.60
TAU	interacts_with	gene	0.60
NEURODEGENERATION	interacts_with	gene	0.60
NEURODEGENERATIVE DISEASES	interacts_with	gene	0.60
MITOCHONDRIAL DYSFUNCTION	interacts_with	gene	0.60
ALZHEIMER	interacts_with	gene	0.60
NEURON	interacts_with	gene	0.60
APOE4	activates	gene	0.60
APOE3	interacts_with	gene	0.60
SRC	activates	gene	0.60
AGING	activates	gene	0.60
GPR132	activates	gene	0.60
AND	inhibits	gene	0.60
OLIGODENDROCYTE	inhibits	gene	0.60
ERK	interacts_with	gene	0.60
MIRNAS	inhibits	gene	0.60
MYELIN	activates	gene	0.60
VESICLE TRAFFICKING	contributes_to	gene	0.60
SREBF2	contributes_to	gene	0.60
FASN	contributes_to	gene	0.60
SREBF1	contributes_to	gene	0.60
CANCER	regulates	gene	0.60

Targeting Hypotheses (4)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
LDLR Ligand-Binding Domain A Fusion for Receptor-Mediated Tr	0.650	neurodegeneration	Blood-brain barrier antibody transport m
APOE4 preferentially signals through LRP1 over LDLR, alterin	0.610	neuroscience	APOE4-driven lipid metabolism dysregulat
oxLDL/LOX-1/ROS Signaling Induces P2RY12 via Nrf2 Activation	0.550	neurodegeneration	What determines P2RY12 receptor expressi
Poorly lipidated APOE4 particles are preferentially routed t	0.340	molecular biology	Does APOE4's reduced lipid-binding direc

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning LDL in their description or question text

No additional research found

LDL

Understanding Entity Pages

Summary

Wiki Pages (9)

VLDL Receptor

LDLRAD3 (LDLR Adapter Protein 1) Protein

LDLRAP1 — Low Density Lipoprotein Receptor Adaptor Protein 1

LDL Receptor Protein

LRP4 Protein - LDL Receptor-Related Protein 4

LDLR Gene

LRP5 Protein - LDL Receptor-Related Protein 5

LRP1B Protein - LDL Receptor-Related Protein 1B

LDLR Protein (Low-Density Lipoprotein Receptor)