gene

HDAC8

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HDAC8: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

143Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

Page for HDAC8 Gene

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🧬 Gene Info

Gene Symbol	HDAC8
Chromosome	Xq13.1
Protein Type	Gene
Function	encodes a zinc-dependent class I histone deacetylase enzyme that plays a critical role in epigenetic regulation of gene expression.
Primary Expression	various tissues, with significant expression in the brain where it regulates chromatin structure and gene transcription essential for neuronal develop
Molecular Weight	42 kDa
Amino Acids	377 aa
Exons	14
Pathways	NF-κB, NF-κB pathway
GeneCards	HDAC8
Human Protein Atlas	HDAC8
[Tau](/proteins/tau) pathology	HDAC8 activity affects tau phosphorylation and aggregation. Studies demonstrate that HDAC8 inhibition reduces tau hyperphosphorylation and neurofibrillary tangle formation [7].
Epigenetic dysregulation	Global histone hypoacetylation is observed in AD brain tissue, and HDAC8 contributes to this epigenetic abnormality [8].
Synaptic plasticity	HDAC8 regulates genes critical for synaptic function and memory formation. HDAC8 activity is elevated in AD, leading to transcriptional repression of neuroprotective genes [9].
Dopaminergic neuron survival	HDAC8 activity affects the expression of genes critical for dopaminergic neuron function and survival. HDAC8 inhibitors have shown neuroprotective effects in PD models [10].
Associated Diseases	Als, Alzheimer
Interactions	AND, APOPTOSIS, App, BAX, Bcl-2, BCL-2
KG Connections	143 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

HDAC8 Gene

gene · 1053 words

→

HDAC8 Protein

protein · 598 words

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Pathway Diagram

graph TD
    HDAC8["HDAC8"]
    Inflammation{"Inflammation"}
    HDAC8 -->|"protects_against"| Inflammation
    Neuroinflammation{"Neuroinflammation"}
    HDAC8 -->|"protects_against"| Neuroinflammation
    Ms{"Ms"}
    HDAC8 -.->|"inhibits"| Ms
    Glaucoma{"Glaucoma"}
    HDAC8 -->|"protects_against"| Glaucoma
    INFLAMMATION(["INFLAMMATION"])
    HDAC8 -->|"protects_against"| INFLAMMATION
    Oxidative_Stress["Oxidative Stress"]
    HDAC8 -->|"activates"| Oxidative_Stress
    JNK(["JNK"])
    JNK -->|"protects_against"| HDAC8
    MAPK(["MAPK"])
    MAPK -->|"protects_against"| HDAC8
    OXIDATIVE_STRESS(["OXIDATIVE STRESS"])
    OXIDATIVE_STRESS -->|"activates"| HDAC8
    S100B(["S100B"])
    S100B -->|"protects_against"| HDAC8
    style HDAC8 fill:#1a3a4a,stroke:#ce93d8,stroke-width:3px,color:#ce93d8

Outgoing (90)

Target	Relation	Type	Str
histone acetylation	suppresses	process	0.90
Ms	inhibits	disease	0.65
Inflammation	protects_against	disease	0.65
Neuroinflammation	protects_against	disease	0.65
Glaucoma	protects_against	disease	0.65
Cancer	therapeutic_target	disease	0.65
Fibrosis	inhibits	disease	0.65
Als	inhibits	disease	0.65
Als	regulates	disease	0.65
Cancer	regulates	disease	0.65
Als	expressed_in	disease	0.65
Alzheimer	expressed_in	disease	0.65
Als	associated_with	disease	0.65
Cancer	inhibits	disease	0.65
App	therapeutic_target	protein	0.60
Raf	therapeutic_target	protein	0.60
Innate Immunity	activates	pathway	0.60
Epigenetic	activates	pathway	0.60
Macrophage	therapeutic_target	cell_type	0.60
App	activates	protein	0.60
Erk	protects_against	protein	0.60
Fus	inhibits	protein	0.60
Immune Response	contributes_to	pathway	0.60
APOPTOSIS	inhibits	gene	0.60
DNA	inhibits	gene	0.60
P53	inhibits	gene	0.60
NEK1	activates	gene	0.60
DNA	expressed_in	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
Epigenetic	expressed_in	pathway	0.60
Wnt	regulates	pathway	0.60
Synaptic Plasticity	regulates	pathway	0.60
App	inhibits	protein	0.60
T Cell	expressed_in	cell_type	0.60
Fus	expressed_in	protein	0.60
HDAC2	therapeutic_target	gene	0.60
HDAC3	therapeutic_target	gene	0.60
HDAC1	therapeutic_target	gene	0.60
Jnk	protects_against	protein	0.60
Rb	inhibits	protein	0.60
BAX	inhibits	gene	0.60
Bcl-2	inhibits	protein	0.60
Stat3	inhibits	protein	0.60
Epithelial	inhibits	cell_type	0.60
P21	inhibits	protein	0.60
Caspase	inhibits	protein	0.60
Epigenetic	inhibits	pathway	0.60
Stem Cell	inhibits	cell_type	0.60
epigenetic regulation	participates_in	pathway	0.60
Wnt signaling	participates_in	pathway	0.60

Incoming (53)

Source	Relation	Type	Str
HSV-gB	upregulates	protein	0.85
HDAC3	associated_with	gene	0.60
ALZHEIMER'S DISEASE	expressed_in	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
WNT	regulates	gene	0.60
AND	expressed_in	gene	0.60
DNA	expressed_in	gene	0.60
BDNF	activates	gene	0.60
HDAC3	activates	gene	0.60
HDAC1	inhibits	gene	0.60
MAPK	protects_against	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
NEUROINFLAMMATION	protects_against	gene	0.60
AND	inhibits	gene	0.60
ERK	protects_against	gene	0.60
RNA	expressed_in	gene	0.60
HDAC	therapeutic_target	gene	0.60
HDAC	inhibits	gene	0.60
RNA	activates	gene	0.60
BCL-2	inhibits	gene	0.60
P21	inhibits	gene	0.60
DNA	activates	gene	0.60
HDAC3	expressed_in	gene	0.60
HDAC1	expressed_in	gene	0.60
HDAC2	expressed_in	gene	0.60
STAT3	expressed_in	gene	0.60
PDK4	expressed_in	gene	0.60
SMC1A	associated_with	gene	0.60
ANKRD11	associated_with	gene	0.60
NIPBL	associated_with	gene	0.60
SMC3	inhibits	gene	0.60
MMP12	inhibits	gene	0.60
PARP1	inhibits	gene	0.60
MRE11	inhibits	gene	0.60
STAT3	inhibits	gene	0.60
HDAC1	regulates	gene	0.60
HDAC2	regulates	gene	0.60
HDAC3	regulates	gene	0.60
HDAC1	interacts_with	gene	0.60
HDAC2	interacts_with	gene	0.60
HDAC3	interacts_with	gene	0.60
JNK	protects_against	gene	0.60
S100B	protects_against	gene	0.60
HDAC3	inhibits	gene	0.60
HDAC6	inhibits	gene	0.60
HDAC	protects_against	gene	0.55
HDAC1	protects_against	gene	0.55
HDAC2	protects_against	gene	0.55
HDAC3	protects_against	gene	0.55
HDAC	associated_with	gene	0.55

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning HDAC8 in their description or question text

No additional research found