concept

ALOX

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ALOX: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

129Connections

3Hypotheses

0Analyses

50Outgoing

47Incoming

2Experiments

0Debates

Summary

ALOX is a concept in neurodegeneration research. Key relationships include: associated with, activates, contributes to. Associated with ALS, Als, Cancer. Connected to 61 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	ALOX
Key Genes/Proteins	ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, ALOXE3
Related Diseases	Als, ALS
Related Pathways	Autophagy
Linked Hypotheses	3 hypotheses

Wiki Pages (2)

Knowledge base pages for this entity

ALOX15 - Arachidonate 15-Lipoxygenase

gene · 840 words

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ALOX15 Protein

protein · 746 words

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Pathway Diagram

graph TD
    ALOX["ALOX"]
    ALOX -->|"activates"| LIPID_PEROXIDATION["LIPID_PEROXIDATION"]
    ALOX -->|"interacts"| Als["Als"]
    ALOX -->|"activates"| Cancer["Cancer"]
    ALOX -->|"interacts"| ALS["ALS"]
    ALOX -->|"interacts"| ALOX15["ALOX15"]
    ALOX -->|"activates"| Ferroptosis["Ferroptosis"]
    GENES["GENES"] -->|"contributes to"| ALOX
    ALOX12["ALOX12"] -->|"contributes to"| ALOX
    ALOX5["ALOX5"] -->|"contributes to"| ALOX
    ALOX15 -->|"interacts"| ALOX
    CANCER["CANCER"] -->|"activates"| ALOX
    AND["AND"] -->|"interacts"| ALOX
    FERROPTOSIS["FERROPTOSIS"] -->|"activates"| ALOX

Outgoing (82)

Target	Relation	Type	Str
LIPID_PEROXIDATION	activates	phenotype	0.72
Als	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Als	associated_with	disease	0.65
ALS	interacts_with	disease	0.65
Cancer	activates	disease	0.65
Als	activates	disease	0.65
Als	interacts_with	disease	0.65
ALS	activates	disease	0.65
Carcinoma	associated_with	disease	0.65
BMAL1	associated_with	gene	0.60
ARNTL	associated_with	gene	0.60
FANCD2	associated_with	gene	0.60
NCOA4	associated_with	gene	0.60
POLG	associated_with	gene	0.60
STING1	associated_with	gene	0.60
MTDNA	associated_with	gene	0.60
SLC7A11	associated_with	gene	0.60
DNA	associated_with	gene	0.60
TFAM	associated_with	gene	0.60
LC3	associated_with	gene	0.60
Autophagy	associated_with	pathway	0.60
Ferroptosis	activates	pathway	0.60
Complement	associated_with	pathway	0.60
FERROPTOSIS	activates	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
ALOX12B	contributes_to	gene	0.60
App	activates	protein	0.60
ATM	associated_with	gene	0.60
CGAS	associated_with	gene	0.60
ATG	associated_with	gene	0.60
TMEM173	associated_with	gene	0.60
AND	activates	gene	0.60
App	interacts_with	protein	0.60
Rb	associated_with	protein	0.60
Ras	associated_with	protein	0.60
ALOX15	interacts_with	gene	0.60
AND	interacts_with	gene	0.60
GENES	contributes_to	gene	0.60
MITOCHONDRIAL DNA	associated_with	gene	0.60
Ferroptosis	therapeutic_target	pathway	0.60
ALOX15B	contributes_to	gene	0.60
CANCER	activates	gene	0.60
ROS	associated_with	gene	0.60
ALOX12	implicated_in	gene	0.60
ALOX12B	implicated_in	gene	0.60
ALOX15	implicated_in	gene	0.60
ALOX15B	implicated_in	gene	0.60
ALOX5	implicated_in	gene	0.60
ALOXE3	implicated_in	gene	0.60

Incoming (47)

Source	Relation	Type	Str
ARNTL	associated_with	gene	0.60
TFAM	associated_with	gene	0.60
POLG	associated_with	gene	0.60
AND	activates	gene	0.60
ALOX15	interacts_with	gene	0.60
CANCER	activates	gene	0.60
CGAS	associated_with	gene	0.60
ATG	associated_with	gene	0.60
ATM	associated_with	gene	0.60
ALOX12	associated_with	gene	0.60
ALOX5	associated_with	gene	0.60
GENES	contributes_to	gene	0.60
GPX4	associated_with	gene	0.60
MITOCHONDRIAL DNA	associated_with	gene	0.60
MAP1LC3B	associated_with	gene	0.60
LC3	associated_with	gene	0.60
BMAL1	associated_with	gene	0.60
DNA	associated_with	gene	0.60
NCOA4	associated_with	gene	0.60
MTDNA	associated_with	gene	0.60
STING1	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
TMEM173	associated_with	gene	0.60
FERROPTOSIS	activates	gene	0.60
ALOX12B	contributes_to	gene	0.60
ALOXE3	contributes_to	gene	0.60
AND	interacts_with	gene	0.60
ALOX15B	contributes_to	gene	0.60
SLC7A11	associated_with	gene	0.60
FANCD2	associated_with	gene	0.60
ROS	associated_with	gene	0.60
SLC7A11	activates	gene	0.50
GPX4	activates	gene	0.50
TMEM173	activates	gene	0.50
TFAM	activates	gene	0.50
MAP1LC3B	activates	gene	0.50
POLG	activates	gene	0.50
FANCD2	activates	protein	0.50
NCOA4	activates	protein	0.50
cancer	activates	disease	0.50
MITOCHONDRIAL DNA	activates	gene	0.50
MTDNA	activates	gene	0.50
ARNTL	activates	gene	0.50
Autophagy	activates	process	0.50
BMAL1	activates	protein	0.50
CGAS	activates	protein	0.50
STING1	activates	protein	0.50

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
ALOX15-Driven Enzymatic Ferroptosis in AD Oligodendrocytes v	0.777	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th	0.695	neurodegeneration	Neuroinflammation resolution mechanisms
ALOX15 Inhibition Combined with Selenium Augmentation for Sy	0.580	-	Ferroptosis in ALS and motor neuron dise

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (2)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Bioinformatics analysis and hub gene identification	exploratory	Alzheimer's disease	0.800	0.00	computational analysis of tran	proposed	N/A
s:** - ALOX15 overexpression in healthy astrocytes should be protectiv	falsification	Neuroinflammation	0.400	0.50	mouse	proposed	$200,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Allosteric properties of mammalian ALOX15 orthologs. [PMID:41654134]	Yang J, Borchert A, Kuhn H	J Biol Chem	2026	1
Alox15/15-HpETE Aggravates Myocardial Ischemia-Reperfusion Injury by Promoting C [PMID:36987924]	Cai W, Liu L, Shi X, Liu Y, Wang J, Fang	Circulation	2023	1
Ferroptosis inhibitor liproxstatin-1 alleviates metabolic dysfunction-associated [PMID:36323829]	Tong J, Lan XT, Zhang Z, Liu Y, Sun DY,	Acta Pharmacol Sin	2023	1
CAF secreted miR-522 suppresses ferroptosis and promotes acquired chemo-resistan [PMID:32106859]	Zhang H, Deng T, Liu R, Ning T, Yang H,	Mol Cancer	2020	1
Regulation of neurotropic signaling by the inducible, NF-kB-sensitive miRNA-125b [PMID:24293102]	Zhao Y, Bhattacharjee S, Jones BM, Hill	Mol Neurobiol	2014	1
ALOX15 exerts tumor-suppressive role in head and neck squamous cell carcinoma vi [PMID:41820595]	Liu A, Zhang X, Li R, Zhang Y, Yang Z, Z	Functional & integrative genom	2026	0
Inhibition of Calcium-Dependent Lipid Droplets Relocation of ACSL4-PKCβ-ALOX15 C [PMID:41589658]	Hou G, Luan J, Xu X, Qin J, Ma S et al.	Adv Sci (Weinh)	2026	0
Inhibition of Ferroptosis in Prostatitis Model by Low Intensity Extracorporeal S [PMID:41714892]	Lin D, Li K, Kuang W, Chen Z, Zhang M	World J Mens Health	2026	0
Sanhua essential oil exerts antidepressant effects in breast cancer-related depr [PMID:41722126]	Li X, Xu Z, Ju P, Dong M, Wang Y et al.	Phytomedicine	2026	0
Oxidative Stress Mediated by Macrophages Promotes Angiogenesis and Early Develop [PMID:41750540]	Man GCW, Borchert A, Zhang T, Hung SW, K	Antioxidants (Basel, Switzerla	2026	0
ALOX15-Derived Oxylipins Attenuate Macrophage Inflammatory Signaling Via a Gαq-P [PMID:41847922]	Hilman A, Ishii Y, Wijatniko BD, Rini DM	FASEB journal : official publi	2026	0
Cigarette Smoke Exacerbates Pressure Overload-Induced Right Ventricular Dysfunct [PMID:41746293]	Zhou L, Bai Q, Shi R, Zeng X, Deng J, Lu	FASEB journal : official publi	2026	0
FGF21 promotes the resolution of inflammation through the ALOX15/SPM pathway in [PMID:41913238]	Chenxi Shen; Yuan Cao; Jinling Wei; Xiny	Respiratory research	2026	0
Lachnospiraceae-bacterium alleviates ischemia-reperfusion injury in steatotic do [PMID:39882747]	Deng S, Cao H, Li T, Wang X, Meng J, Zen	Gut microbes	2025	0
Exosomes as nanocarriers for brain-targeted delivery of therapeutic nucleic acid [PMID:40533746]	["Sanadgol N", "Abedi M", "Hashemzaei M"	Journal of nanobiotechnology	2025	0
FGF21 modulates immunometabolic homeostasis via the ALOX15/15-HETE axis in early [PMID:39362839]	Yang X, Chen H, Shen W, Chen Y, Lin Z, Z	Nature communications	2024	0
Inflammatory Processes in Alzheimer's Disease-Pathomechanism, Diagnosis and Trea [PMID:37047492]	Unknown	Int J Mol Sci	2023	0
Exploration of prognosis and immunometabolism landscapes in ER+ breast cancer ba [PMID:37469520]	Shen L, Huang H, Li J, Chen W, Yao Y, Hu	Frontiers in immunology	2023	0
Pathogenesis of Alzheimer's Disease. [PMID:36613544]	Unknown	Int J Mol Sci	2022	0
Alzheimer's disease. [PMID:31753135]	["Soria Lopez, Jose A", "Gonz\u00e1lez,	Handbook of clinical neurology	2019	0

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ALOX in their description or question text

No additional research found