gene 1,202 words KG: MAP1LC3B
Contents

MAP1LC3B — LC3B

🧬 Gene Info
Gene SymbolMAP1LC3B
Full NameMicrotubule-Associated Protein 1 Light Chain 3 Beta (LC3B)
AliasesLC3B
Chromosome16q24.2
FunctionMAP1LC3B encodes LC3B, a key protein in the autophagy pathway.
Primary ExpressionUbiquitous, high in brain (neurons and glia), liver, heart, skeletal muscle
Molecular Weight14.5 kDa
Amino Acids125 aa
PathwaysApoptosis, Autophagy, Immune Response, Innate Immunity, Mapk
UniProt IDQ9GZQ8
NCBI Gene ID81631
Ensembl IDENSG00000140941
OMIM609605
GeneCardsMAP1LC3B
Human Protein AtlasMAP1LC3B
Associated DiseasesAging, Als, Alzheimer, Alzheimer's disease, Amyotrophic Lateral Sclerosis
Known Drugs/Compoundscocaine, LPS, rapamycin
InteractionsABCD3, ACTB, AGING, AIF1, AIFM1, ALOX
KG Connections1964 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (30)

SASP-Mediated Complement Cascade Amplification
Score: 0.70
APOE-Dependent Autophagy Restoration
Score: 0.88
Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
Circadian-Synchronized Proteostasis Enhancement
Score: 0.74
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.74
Phase-Separated Organelle Targeting
Score: 0.73
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.72
Astroglial Gap Junction Coordination via Connexin-43 Phospho
Score: 0.72
Stress Granule Phase Separation Modulators
Score: 0.72
Metabolic Circuit Breaker via Lipid Droplet Modulation
Score: 0.71
Autophagosome Maturation Checkpoint Control
Score: 0.71
Lysosomal Calcium Channel Modulation Therapy
Score: 0.70
Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.70
Mitochondrial Transfer Pathway Enhancement
Score: 0.70
Cross-Seeding Prevention Strategy
Score: 0.69
Lysosomal Positioning Dynamics Modulation
Score: 0.69
CX43 hemichannel engineering enables size-selective mitochon
Score: 0.69
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Related Analyses (8)

Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived

Related Experiments (11)

Viral and Post-Infectious Mechanisms in ALS — Experiment Des
clinical · proposed · Score: 0.40
Proposed experiment from debate on Senolytics targeting p16/
falsification · proposed · Score: 0.40
Mechanism: Why Does Amyloid Removal Only Slow Decline 27%?
clinical · proposed · Score: 0.40
Experiment: Autoimmune Hypothesis Testing in AD
clinical · proposed · Score: 0.40
Mixed Pathology Effects on Parkinson's Disease Progression a
clinical · proposed · Score: 0.40

See Also (6)

ABCD3 Gene
gene · KG edge: interacts_with
ACTB Gene
gene · KG edge: activates
AIF1 Gene
gene · KG edge: activates
AIM2 Inflammasome Modulation Therapy for Neurodegenerat
idea · KG edge: associated_with
Actin Cytoskeleton Dynamics in Neurodegeneration
mechanism · KG edge: co_discussed

Knowledge Graph (12 edges)

ACTB regulates MAP1LC3B
PPARA regulates MAP1LC3B
CAT regulates MAP1LC3B
SQSTM1 regulates MAP1LC3B
RPS6KB1 regulates MAP1LC3B
RAB7A regulates MAP1LC3B
SREBF1 regulates MAP1LC3B
EIF4EBP1 regulates MAP1LC3B
CTSD regulates MAP1LC3B
PPARGC1A regulates MAP1LC3B

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