concept

LPS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LPS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

37Connections

4Hypotheses

3Analyses

36Outgoing

1Incoming

1Experiments

3Debates

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💡 Concept Info

Name	LPS
Key Genes/Proteins	ACSL4, BAX, BCL2, BDNF, C1Q, GFAP
Related Diseases	Alzheimer's disease, depression, major depressive disorder
Related Pathways	autophagy, MAPK
Linked Hypotheses	4 hypotheses

Wiki Pages (1)

Knowledge base pages for this entity

LLPS Modulator Therapy

therapeutic · 1296 words

→

Pathway Diagram

graph TD
    LPS["LPS"]
    LPS -->|"activates"| NF_kappaB["NF-kappaB"]
    LPS -->|"activates"| MAPK["MAPK"]
    LPS -->|"causes"| pulmonary_inflammation["pulmonary inflammation"]
    LPS -->|"causes"| neuroinflammation["neuroinflammation"]
    LPS -->|"causes"| Acute_Lung_Injury["Acute Lung Injury"]
    LPS -->|"activates"| NLRP3_Inflammasome_Activation["NLRP3 Inflammasome Activation"]
    LPS -->|"causes"| Septic_Cardiomyopathy["Septic Cardiomyopathy"]
    LPS -->|"upregulates"| C3["C3"]
    LOXL3["LOXL3"] -->|"modulates"| LPS

Outgoing (36)

Target	Relation	Type	Str
C3	upregulates	protein	0.90
GFAP	activates	protein	0.90
NLRP3 Inflammasome Activation	activates	process	0.90
Septic Cardiomyopathy	causes	disease	0.90
MAPK	activates	pathway	0.90
neuroinflammation	causes	phenotype	0.90
NF-kappaB	activates	protein	0.90
pulmonary inflammation	causes	phenotype	0.90
NLRP3 Inflammasome Activation	associated_with	process	0.85
Ferroptosis	associated_with	process	0.85
MTOR	activates	gene	0.80
GFAP	contributes_to	protein	0.80
autophagy	activates	pathway	0.80
BAX	activates	gene	0.75
Alzheimer's disease	associated_with	disease	0.70
BCL2	inhibits	protein	0.70
microglia	activates	cell_type	0.70
NLRP3	activates	protein	0.70
PI3K	activates	protein	0.70
BDNF	regulates	protein	0.70
PINK1	inhibits	protein	0.70
PINK1/Parkin	inhibits	protein	0.70
ACSL4	induces	protein	0.70
TNF	activates	protein	0.70
TLR4	activates	protein	0.70
mitophagy	inhibits	process	0.70
NLRP3 inflammasome	activates	protein	0.70
MAP1LC3B	inhibits	protein	0.70
major depressive disorder	causes	disease	0.70
PRDX1	inhibits	protein	0.64
MACROPHAGES	activates	cell_type	0.64
NEUROINFLAMMATION	activates	pathway	0.64
MMP9	activates	protein	0.64
C1Q	activates	protein	0.56
depression	causes	disease	0.56
PYROPTOSIS	activates	phenotype	0.56

Incoming (1)

Source	Relation	Type	Str
LRRK2	interacts_with	gene	0.60

Targeting Hypotheses (4)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
TLR4/MyD88/NF-κB Axis Blockade to Interrupt LPS-Mediated Gut	0.703	neurodegeneration	How do gut microbiome-derived metabolite
LPS-primed microglial trained immunity establishes persisten	0.670	neurodegeneration	Synaptic pruning by microglia in neurode
Intestinal Permeability Defects → Systemic LPS Translocation	0.630	neurodegeneration	What are the mechanisms by which gut mic
Liquid-Liquid Phase Separation (LLPS) Saturation Partitionin	0.461	neurodegeneration	What determines the spatial organization