concept

TSPAN1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TSPAN1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

122Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	TSPAN1
Key Genes/Proteins	Actin, AMPK, AND, APC, ATG, AXIN
Related Diseases	Als, ALS
Related Pathways	autophagy pathway

Pathway Diagram

graph TD
    TSPAN1["TSPAN1"]
    TSPAN1 -->|"activates"| Autophagy["Autophagy"]
    TSPAN1 -->|"upregulates"| Pancreatic_Cancer_Cell_Prolife["Pancreatic Cancer Cell Proliferation"]
    TSPAN1 -->|"expressed in"| Pancreatic_Cancer["Pancreatic Cancer"]
    TSPAN1 -->|"correlates_with"| Poor_Overall_Survival["Poor Overall Survival"]
    TSPAN1 -->|"regulates"| LC3["LC3"]
    TSPAN1 -->|"regulates"| LC3II["LC3II"]
    TSPAN1 -->|"regulates"| SQSTM1["SQSTM1"]
    TSPAN1 -->|"correlates_with"| Overall_Survival["Overall Survival"]
    FAM83A["FAM83A"] -->|"regulates"| TSPAN1
    MIR454["MIR454"] -->|"regulates"| TSPAN1
    LC3 -->|"interacts"| TSPAN1
    WNT["WNT"] -->|"activates"| TSPAN1
    RAS["RAS"] -->|"interacts"| TSPAN1
    SQSTM1 -->|"regulates"| TSPAN1
    GFP["GFP"] -->|"regulates"| TSPAN1
    CTNNB1["CTNNB1"] -->|"activates"| TSPAN1

Outgoing (62)

Target	Relation	Type	Str
Autophagy	activates	process	0.95
Autophagy	associated_with	process	0.95
Pancreatic Cancer	associated_with	disease	0.95
Pancreatic Cancer Cell Proliferation	upregulates	phenotype	0.90
Pancreatic Cancer	drives	disease	0.90
Pancreatic Cancer Cell Proliferation	associated_with	phenotype	0.90
Pancreatic Cancer	expressed_in	disease	0.90
Autophagy Maturation	promotes	process	0.90
Map1Lc3B	binds	protein	0.90
Sqstm1	downregulates	protein	0.85
Poor Overall Survival	correlates_with	phenotype	0.85
LC3-II	modulates	protein	0.85
SQSTM1	modulates	gene	0.85
LC3	regulates	entity	0.85
Pancreatic Cancer	therapeutic_target	disease	0.80
Overall Survival	correlates_with	phenotype	0.80
autophagy flux	promotes	process	0.80
WNT-CTNNB1 signaling	mediates	pathway	0.80
AUTOPHAGY	promotes	process	0.80
LC3II	regulates	protein	0.80
SQSTM1	regulates	gene	0.80
Als	associated_with	disease	0.65
Tumor	activates	disease	0.65
ALS	associated_with	disease	0.65
Carcinoma	associated_with	disease	0.65
Tumor	therapeutic_target	disease	0.65
Cancer	activates	disease	0.65
AND	activates	gene	0.60
CTNNB1	activates	gene	0.60
CANCER	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
Wnt	activates	pathway	0.60
WNT	activates	gene	0.60
Wnt signaling	participates_in	pathway	0.60
autophagy pathway	participates_in	pathway	0.60
RNA	associated_with	gene	0.60
AMPK	associated_with	gene	0.60
CCND1	associated_with	gene	0.60
GAPDH	associated_with	gene	0.60
APC	associated_with	gene	0.60
AXIN	associated_with	gene	0.60
MYC	associated_with	gene	0.60
ATG	associated_with	gene	0.60
RAB7A	associated_with	gene	0.60
GSK3B	associated_with	gene	0.60
GFP	regulates	gene	0.60
FAM83A	activates	gene	0.60
Raf	associated_with	protein	0.60
Ras	interacts_with	protein	0.60
cancer	activates	disease	0.60

Incoming (60)

Source	Relation	Type	Str
FAM83A	regulates	gene	0.85
MIR454	regulates	gene	0.85
CTNNB1	interacts_with	gene	0.80
LC3	interacts_with	gene	0.60
RAB7A	associated_with	gene	0.60
WNT	activates	gene	0.60
RAS	interacts_with	gene	0.60
GSK3B	associated_with	gene	0.60
APC	associated_with	gene	0.60
CSNK1A1	associated_with	gene	0.60
SQSTM1	regulates	gene	0.60
GFP	regulates	gene	0.60
GAPDH	associated_with	gene	0.60
AXIN2	associated_with	gene	0.60
RNA	associated_with	gene	0.60
LAMP1	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
CTNNB1	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
AMPK	associated_with	gene	0.60
FAM83A	activates	gene	0.60
P62	inhibits	gene	0.60
CANCER	activates	gene	0.60
CCND1	associated_with	gene	0.60
MYC	associated_with	gene	0.60
ATG	associated_with	gene	0.60
TCF4	associated_with	gene	0.60
CYCLIN D1	associated_with	gene	0.60
MIR454	activates	gene	0.60
MTOR	associated_with	gene	0.60
AXIN	associated_with	gene	0.60
MKI67	activates	gene	0.60
SQSTM1	inhibits	gene	0.60
LC3	activates	gene	0.60
FAM83A	targets	gene	0.60
MIR454	targets	gene	0.60
FAM83A	associated_with	gene	0.60
MIR454	associated_with	gene	0.60
AMPK	activates	gene	0.60
APC	activates	gene	0.60
ATG	activates	gene	0.60
AXIN2	activates	gene	0.60
BECN1	activates	gene	0.60
CCND1	activates	gene	0.60
CSNK1A1	activates	gene	0.60
GFP	inhibits	gene	0.60
GFP	activates	gene	0.60
GSK3B	activates	gene	0.60
LAMP1	activates	gene	0.60
MAP1LC3	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TSPAN1 in their description or question text

No additional research found