concept

LDH

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LDH: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

96Connections

0Hypotheses

0Analyses

50Outgoing

42Incoming

0Experiments

0Debates

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💡 Concept Info

Name	LDH
Key Genes/Proteins	ACTB, ADIPOQ, AGER, ANXA5, APP, ATP
Related Pathways	apoptosis pathway, autophagy pathway, blood-brain barrier

Wiki Pages (11)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    LDH[LDH]
    LDH -.biomarker for.-> ROS[ROS]
    LDH -->|expressed in| TNF[TNF]
    LDH -->|activates| S100B[S100B]
    LDH -->|activates| TGM2[TGM2]
    LDH -->|activates| PGC1A[PGC1A]
    LDH -->|activates| PLIN2[PLIN2]
    LDH -->|activates| PPARA[PPARA]
    LDH -->|activates| SGLT2[SGLT2]
    LDH -->|activates| ULK1[ULK1]
    Glucose[Glucose] -->|upregulates| LDH
    high_glucose[high glucose] -->|upregulates| LDH
    AE[AE] -->|downregulates| LDH
    GPX1[GPX1] -.biomarker for.-> LDH
    ADIPOQ[ADIPOQ] -->|activates| LDH
    APP[APP] -->|activates| LDH
    C1Q[C1Q] -->|activates| LDH
    C3[C3] -->|activates| LDH
    HMGB1[HMGB1] -->|activates| LDH
    HK2[HK2] -->|activates| LDH

Outgoing (54)

Target	Relation	Type	Str
ROS	inhibits	gene	0.70
ROS	associated_with	gene	0.70
ROS	biomarker_for	gene	0.70
TOMM20	inhibits	gene	0.60
PINK1	inhibits	gene	0.60
neuroinflammation	associated_with	disease	0.60
RB1	biomarker_for	gene	0.60
Notch signaling	participates_in	pathway	0.60
TCF4	activates	gene	0.60
MLKL	activates	gene	0.60
RIPK1	activates	gene	0.60
RIPK3	activates	gene	0.60
PECAM1	regulates	gene	0.60
RORC	regulates	gene	0.60
SQSTM1	regulates	gene	0.60
TNF	regulates	gene	0.60
VIM	regulates	gene	0.60
oxidative stress response	participates_in	pathway	0.60
apoptosis pathway	participates_in	pathway	0.60
autophagy pathway	participates_in	pathway	0.60
lipid metabolism	participates_in	pathway	0.60
Parkinson's disease	associated_with	disease	0.60
TNF	expressed_in	gene	0.60
Parkinson's disease	activates	disease	0.60
ULK1	activates	gene	0.60
NTS	associated_with	gene	0.60
MAP1LC3	regulates	gene	0.60
TGM2	activates	gene	0.60
PGC1A	activates	gene	0.60
PLIN2	activates	gene	0.60
PPARA	activates	gene	0.60
SGLT2	activates	gene	0.60
TNF	biomarker_for	gene	0.60
VIM	biomarker_for	gene	0.60
neurodegeneration	activates	disease	0.60
TH	activates	gene	0.60
ferroptosis	participates_in	pathway	0.60
PINK1	activates	gene	0.60
PTEN	activates	gene	0.60
PTX3	activates	gene	0.60
TGF-beta signaling	participates_in	pathway	0.60
pyroptosis	participates_in	pathway	0.60
ROS	activates	gene	0.60
S100B	activates	gene	0.60
PKM2	inhibits	gene	0.60
traumatic brain injury	activates	disease	0.60
blood-brain barrier	participates_in	pathway	0.60
endothelial cells	expressed_in	cell_type	0.60
NLR	associated_with	gene	0.60
NLR	biomarker_for	gene	0.60

Incoming (42)

Source	Relation	Type	Str
Glucose	upregulates	compound	0.90
high glucose	upregulates	compound	0.85
AE	downregulates	compound	0.80
APP	activates	gene	0.60
C1Q	activates	gene	0.60
C3	activates	gene	0.60
HMGB1	activates	gene	0.60
LC3	inhibits	gene	0.60
CD31	regulates	gene	0.60
CKB	regulates	gene	0.60
CTS	regulates	gene	0.60
GAPDH	regulates	gene	0.60
GATA3	regulates	gene	0.60
GLB1	regulates	gene	0.60
IL1RL1	regulates	gene	0.60
IL4	regulates	gene	0.60
IL7R	regulates	gene	0.60
LC3	regulates	gene	0.60
GSH	activates	gene	0.60
ADIPOQ	activates	gene	0.60
ANXA5	regulates	gene	0.60
HIF	activates	gene	0.60
ACTB	regulates	gene	0.60
BECN1	regulates	gene	0.60
DGAT1	activates	gene	0.60
GHRL	activates	gene	0.60
GSH	biomarker_for	gene	0.60
GSDME	activates	gene	0.60
HIF	interacts_with	gene	0.60
ATP	activates	gene	0.60
HK2	activates	gene	0.60
CHMP4B	associated_with	gene	0.60
quercetin	targets	drug	0.60
ATP	associated_with	gene	0.60
ATP	inhibits	gene	0.60
CASP1	activates	gene	0.60
GSDMD	activates	gene	0.60
GPX1	biomarker_for	gene	0.60
GR	biomarker_for	gene	0.60
CX43	biomarker_for	gene	0.60
IL1B	activates	gene	0.60
AGER	associated_with	gene	0.30

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

LDH

Understanding Entity Pages

Wiki Pages (11)

ALDH1L1

ALDH1A3 — Aldehyde Dehydrogenase 1 Family Member A3

ALDH1A2 (Aldehyde Dehydrogenase 1 Family Member A2)

ALDH1A3 Protein

ALDH1L1 Protein

ALDH1A1+ Dopamine Neurons

ALDH2 — Aldehyde Dehydrogenase 2

ALDH2 Protein — Aldehyde Dehydrogenase 2

ALDH1A2 Protein

ALDH1A1 Gene

ALDH1A1 Protein (Aldehyde Dehydrogenase 1A1)