Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about AE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| PI3K | activates | protein | 0.80 |
| AKT | activates | protein | 0.80 |
| MDA | downregulates | compound | 0.80 |
| LDH | downregulates | protein | 0.80 |
| Caspase 3 | downregulates | protein | 0.80 |
| SOD | upregulates | protein | 0.80 |
| Bcl-2 | upregulates | protein | 0.80 |
| Bax | downregulates | protein | 0.80 |
| Ischemic stroke | treats | disease | 0.80 |
| mTOR | activates | protein | 0.80 |
| NF-κB | inhibits | protein | 0.80 |
| TNF-α | downregulates | protein | 0.80 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| ω-3 Docosahexaenoic Acid (DHA) Epoxide Generation via CYP2J2 | 0.752 | lipidomics | Lipid metabolism dysregulation in Alzhei |
| OPA1-Mediated Cristae Architecture Vulnerability | 0.490 | neurodegeneration | What determines the specificity of TDP-4 |
| Astrocytic APOE4 Disruption of GABAergic Support Increasing | 0.450 | neurodegeneration | How does APOE4 mechanistically increase |
| GABAergic Hub Stabilization Through α5-Subunit Inverse Agoni | 0.430 | connectomics | Human connectome alterations in Alzheime |
| ω-3 Docosahexaenoic Acid (DHA) Metabolism via 15-Lipoxygenas | 0.380 | lipidomics | Lipid metabolism dysregulation in Alzhei |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Memorable Food: Fighting Age-Related Neurodegeneration by Precision Nutrition. [PMID:34422879] | ["Milo\u0161evi\u0107 M", "Arsi\u0107 A" | Frontiers in nutrition | 2021 | 0 |
| Dietary DHA and health: cognitive function ageing. [PMID:27866493] | Unknown | Nutr Res Rev | 2016 | 0 |
| Docosahexaenoic acid and synaptic protection in Alzheimer's disease mice. [PMID:20211757] | Unknown | Biochim Biophys Acta | 2010 | 0 |
| Survival signalling in Alzheimer's disease. [PMID:17073801] | Unknown | Biochem Soc Trans | 2006 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning AE in their description or question text
No additional research found