gene 699 words KG: ent-gene-0777e1b2
Contents

ALDH2 — Aldehyde Dehydrogenase 2

🧬 Gene Info
Gene SymbolALDH2
Full NameAldehyde Dehydrogenase 2
AliasesALDH-E2
Chromosome12q24.12
Protein TypeEnzyme
FunctionMitochondrial aldehyde detoxification enzyme
Subcellular Localizationthe mitochondrial matrix. Each subunit contains:
Molecular Weight56.4 kDa
Amino Acids517
PathwaysEthanol metabolism, Oxidative stress response
UniProt IDP05091
Ensembl IDENSG00000111275
GeneCardsALDH2
Human Protein AtlasALDH2
Catalytic domainContains the active site with catalytic cysteine (Cys302)
Associated DiseasesAls, Atherosclerosis, Cardiovascular, Coronary Artery Disease, Infection, Inflammation
InteractionsACACA, AND, CPT1A, FASN, FERROPTOSIS, IL1B
KG Connections111 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (20)

APOE-Dependent Autophagy Restoration
Score: 0.88
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.74
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
APOE Isoform Conversion Therapy
Score: 0.72
Cross-Seeding Prevention Strategy
Score: 0.69
Glycine-Rich Domain Competitive Inhibition
Score: 0.64
Cryptic Exon Silencing Restoration
Score: 0.53
RNA-Binding Competition Therapy for TDP-43 Cross-Seeding
Score: 0.47
SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK
Score: 0.74
Lysosomal Enzyme Trafficking Correction
Score: 0.71
Mitochondrial-Nuclear Epigenetic Cross-Talk Restoration
Score: 0.70
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
HSP90-Tau Disaggregation Complex Enhancement
Score: 0.57
Blood-Brain Barrier SPM Shuttle System
Score: 0.53
Proteostasis Enhancement via APOE Chaperone Targeting
Score: 0.72

Related Analyses (6)

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

See Also (7)

CDK1 — Cyclin-Dependent Kinase 1
gene · KG edge: regulates
CTSB Gene
gene · KG edge: regulates
CTSD — Cathepsin D
gene · KG edge: regulates
FASN Gene
gene · KG edge: activates
APOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: associated_with

Knowledge Graph (2 edges)

ent-gene-0777e1b2 data_in benchmark_ot_ad_answer_key:ALDH2
benchmark_ot_ad_answer_key:ALDH2 data_in ent-gene-0777e1b2

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