| Gene Symbol | ALDH1A1 |
| Aliases | ALDH1A1PROTEIN |
| Function | ALDH1A1 encodes aldehyde dehydrogenase 1A1, a cytosolic enzyme that catalyzes the oxidation of aldehydes to carboxylic acids. |
| Primary Expression | multiple brain regions: - Substantia nigra pars compacta - dopaminergic neurons (high expression) - Ventral tegmental area - dopaminergic neur |
| Pathways | Complement, Epigenetic, Ferroptosis, Metastasis, Notch |
| Ensembl ID | ENSG00000153208 |
| GeneCards | ALDH1A1 |
| Human Protein Atlas | ALDH1A1 |
| NAD-binding Domain | Binds NAD+ cofactor in a Rossmann fold structure [4] |
| Catalytic Domain | Contains the active site with a catalytic cysteine (Cys302) [4] |
| Substrate-binding Pocket | Accommodates various aldehyde substrates including retinaldehydes and dopamine-derived aldehydes [5] |
| Oligomerization Interface | Mediates tetramer formation essential for enzyme activity [4] |
| Selective Loss | ALDH1A1+ dopaminergic neurons in substantia nigra are particularly vulnerable in PD [3] |
| Reduced ALDH1A1 Expression | Decreased ALDH1A1 mRNA and protein in PD substantia nigra [11] |
| DOPAL Accumulation | Impaired aldehyde detoxification leads to DOPAL accumulation [9] |
| Associated Diseases | Aging, Als, Diabetes, Ms |
| Interactions | ASTROCYTE, CANCER, EGFR, FBXL12, FERROPTOSIS, MICROGLIA |
| KG Connections | 148 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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