gene

IL1RL1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IL1RL1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

38Connections

0Hypotheses

0Analyses

24Outgoing

14Incoming

0Experiments

0Debates

Summary

IL1RL1 is a gene implicated in neurodegeneration research. Key relationships include: implicated in, activates, associated with. Connected to 10 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	IL1RL1
Full Name	Interleukin-1 Receptor-Like 1 (ST2)
Chromosome	2q12
Protein Family	IL-1 receptor family
Protein Type	Receptor
Function	Endogenous alarmin signals danger
Primary Expression	Nuclear localization in structural cells
Molecular Weight	63 kDa
Amino Acids	556 aa
Exons	11
Pathways	MAPK
UniProt ID	Q9INT6
NCBI Gene ID	9173
Ensembl ID	ENSG00000115607
OMIM	601203
GeneCards	IL1RL1
Human Protein Atlas	IL1RL1
Associated Diseases	ALS
Interactions	ADRA1A, ADRA2A, ADRB1, ASTROCYTE, ASTROCYTES, DBH
KG Connections	38 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: IL1RL1 — AlphaFold Q9INT6 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

IL1RL1 Gene

gene · 2124 words

→

IL1RL1 Protein (ST2)

protein · 599 words

→

Pathway Diagram

flowchart TD
    N0["IL1RL1"]
    N1["Epigenetic"]
    N0 -->|"associated with"| N1
    N2["ASTROCYTES"]
    N0 -->|"activates"| N2
    N3["ASTROCYTE"]
    N0 -->|"activates"| N3
    N4["PHAGOCYTOSIS"]
    N0 -->|"implicated in"| N4
    N5["AKT"]
    N0 -->|"implicated in"| N5
    N6["MITOCHONDRIA"]
    N0 -->|"implicated in"| N6
    N7["IL33"]
    N0 -->|"activates"| N7
    N8["MICROGLIA"]
    N0 -->|"activates"| N8
    N9["Phagocytosis"]
    N0 -->|"implicated in"| N9
    N10["neurodegeneration"]
    N0 -->|"implicated in"| N10

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N2 gene
    class N3 gene
    class N4 gene
    class N5 gene
    class N6 gene
    class N7 gene
    class N8 gene
    class N9 pathway

Outgoing (24)

Target	Relation	Type	Str
IL4	regulates	gene	0.60
IL7R	regulates	gene	0.60
LC3	regulates	gene	0.60
LDH	regulates	gene	0.60
PECAM1	regulates	gene	0.60
RORC	regulates	gene	0.60
SQSTM1	regulates	gene	0.60
TNF	regulates	gene	0.60
VIM	regulates	gene	0.60
IL33	interacts_with	gene	0.60
NRG1	interacts_with	gene	0.60
ALS	associated_with	disease	0.60
MAP1LC3	regulates	gene	0.60
autophagy pathway	participates_in	pathway	0.60
oxidative stress response	participates_in	pathway	0.60
endothelial cells	expressed_in	cell_type	0.60
ASTROCYTES	activates	gene	0.60
ASTROCYTE	activates	gene	0.60
PHAGOCYTOSIS	implicated_in	gene	0.60
MITOCHONDRIA	implicated_in	gene	0.60
MICROGLIA	activates	gene	0.60
Phagocytosis	implicated_in	pathway	0.60
AKT	implicated_in	gene	0.60
IL33	activates	gene	0.60

Incoming (14)

Source	Relation	Type	Str
ANXA5	regulates	gene	0.60
ACTB	regulates	gene	0.60
BECN1	regulates	gene	0.60
CD31	regulates	gene	0.60
CKB	regulates	gene	0.60
CTS	regulates	gene	0.60
GAPDH	regulates	gene	0.60
GATA3	regulates	gene	0.60
GLB1	regulates	gene	0.60
ADRA1A	interacts_with	gene	0.60
ADRA2A	interacts_with	gene	0.60
ADRB1	interacts_with	gene	0.60
DBH	interacts_with	gene	0.60
ERBB4	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning IL1RL1 in their description or question text

No additional research found