| Gene Symbol | ALDH1L1 |
| Full Name | Aldehyde Dehydrogenase 1 Family Member L1 |
| Chromosome | 3q21.3 |
| Protein Type | Enzyme |
| Function | is a folate-metabolizing enzyme that catalyzes the oxidation of 10-formyltetrahydrofolate to tetrahydrofolate in the mitochondrial folate pathway. |
| Primary Expression | the liver and brain, particularly in astrocytes where it serves as a specific marker for mature astrocytes |
| Molecular Weight | 99 kDa |
| Amino Acids | 902 aa |
| UniProt ID | O75459 |
| NCBI Gene ID | 108 |
| Ensembl ID | ENSG00000135917 |
| OMIM | 600182 |
| GeneCards | ALDH1L1 |
| Human Protein Atlas | ALDH1L1 |
| Full-length ALDH1L1 (902 aa) | The canonical mitochondrial enzyme |
| Associated Diseases | Als, Frontotemporal Dementia, Glioma, Neuroinflammation, Tauopathy, Tumor |
| Interactions | ALZHEIMER, AMYLOID, APP/PS1, ASC, ASTROCYTE, ASTROCYTES |
| KG Connections | 120 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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