gene

RORC

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RORC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

63Connections

0Hypotheses

1Analyses

31Outgoing

32Incoming

0Experiments

1Debates

Summary

RORC encodes a nuclear receptor regulating circadian rhythm, metabolism, and immune function with implications for neurodegeneration

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🧬 Gene Info

Gene Symbol	RORC
Full Name	RAR-Related Orphan Receptor C
Chromosome	1q21.2
Protein Type	Receptor
Function	The circadian transcriptional-translational feedback loop operates as follows
UniProt ID	[P51586](https://www.uniprot.org/uniprot/P51586)
Ensembl ID	ENSG00000143357
GeneCards	RORC
Human Protein Atlas	RORC
Metabolic genes	GLUT4, PEPCK, fatty acid oxidation enzymes
Immune genes	IL-17, IL-22, antimicrobial peptides
Clock genes	NR1D1 (Rev-Erbα), NPAS2
Neuronal genes	Synaptic plasticity factors, neurotransmitter receptors
Associated Diseases	Alzheimer's disease, Parkinson's disease
Known Drugs/Compounds	paeoniflorin
Interactions	AHR, Cytokine, CYTOKINES, FOXP3, IL-22, STAT3
KG Connections	63 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

RORC Gene

gene · 2320 words

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Pathway Diagram

graph TD
    RORC["RORC"]
    CD4["CD4"]
    RORC -->|"therapeutic target"| CD4
    FOXP3["FOXP3"]
    RORC -->|"activates"| FOXP3
    RORC -->|"associated with"| CD4
    CD14["CD14"]
    RORC -->|"associated with"| CD14
    neurodegeneration["neurodegeneration"]
    RORC -->|"implicated in"| neurodegeneration
    CD14 -->|"therapeutic target"| RORC
    CD4 -->|"therapeutic target"| RORC
    FOXP3 -->|"regulates"| RORC
    FOXP3 -->|"activates"| RORC
    AND["AND"]
    AND -->|"associated with"| RORC
    style RORC fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (31)

Target	Relation	Type	Str
Th17 cell differentiation	drives	process	0.90
paeoniflorin	interacts_with	compound	0.85
STAT3	interacts_with	gene	0.80
Senescence	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
Stroke	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
CYTOKINES	inhibits	gene	0.60
Cytokine	inhibits	protein	0.60
AHR	inhibits	gene	0.60
JUN	expressed_in	gene	0.60
AND	associated_with	gene	0.60
Monocyte	therapeutic_target	cell_type	0.60
autophagy pathway	participates_in	pathway	0.60
oxidative stress response	participates_in	pathway	0.60
endothelial cells	expressed_in	cell_type	0.60
Stem Cell	expressed_in	cell_type	0.60
CD14	associated_with	gene	0.60
CD4	associated_with	gene	0.60
Epigenetic	expressed_in	pathway	0.60
Fibroblast	expressed_in	cell_type	0.60
T Cell	expressed_in	cell_type	0.60
Monocyte	expressed_in	cell_type	0.60
CD4	therapeutic_target	gene	0.60
FOXP3	activates	gene	0.60
CD14	therapeutic_target	gene	0.60
SQSTM1	regulates	gene	0.60
TNF	regulates	gene	0.60
VIM	regulates	gene	0.60
macrophages	expressed_in	cell_type	0.60
MONOCYTES	associated_with	concept	0.50

Incoming (32)

Source	Relation	Type	Str
MIR20B	suppresses	gene	0.85
IL-22	inhibits	gene	0.60
STROKE	therapeutic_target	gene	0.60
CD14	therapeutic_target	gene	0.60
CD4	therapeutic_target	gene	0.60
FOXP3	regulates	gene	0.60
FOXP3	activates	gene	0.60
CD14	treats	entity	0.60
CD4	treats	entity	0.60
ANXA5	regulates	gene	0.60
MAP1LC3	regulates	gene	0.60
ACTB	regulates	gene	0.60
RNA	expressed_in	gene	0.60
CD4	associated_with	gene	0.60
BECN1	regulates	gene	0.60
CD31	regulates	gene	0.60
CKB	regulates	gene	0.60
CTS	regulates	gene	0.60
GAPDH	regulates	gene	0.60
GATA3	regulates	gene	0.60
GLB1	regulates	gene	0.60
IL1RL1	regulates	gene	0.60
IL4	regulates	gene	0.60
IL7R	regulates	gene	0.60
LC3	regulates	gene	0.60
LDH	regulates	gene	0.60
PECAM1	regulates	gene	0.60
CHI3L1	expressed_in	gene	0.60
CD14	associated_with	gene	0.50
CD14	co_expressed_with	gene	0.50
CD4	co_expressed_with	gene	0.50
H4	associated_with	hypothesis	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

neurodegeneration | 2026-04-01 | 5 hypotheses Top: 0.720

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

This analysis aims to elucidate the mechanisms by which gut microbiome dysbiosis

closed · Rounds: 4 · Score: 0.82 · 2026-04-22

Related Research

Hypotheses and analyses mentioning RORC in their description or question text

No additional research found