concept

GR

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

79Connections

30Hypotheses

0Analyses

50Outgoing

26Incoming

12Experiments

0Debates

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💡 Concept Info

Name	GR
Key Genes/Proteins	AGER, AKT, ALS, AR, BAG3, BDNF
Related Diseases	Alzheimer's disease
Related Pathways	apoptosis pathway, autophagy pathway, CRISPR-Cas
Linked Hypotheses	2 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    GR[GR]
    GR -->|regulates| Glioblastoma[Glioblastoma]
    GR -->|mediates| Memory_Impairment[Memory Impairment]
    GR -.protects against.-> Ferroptosis[Ferroptosis]
    GR -->|regulates| Microglial_Activation[Microglial Activation]
    GR -->|contributes to| Glutamate_Excitotoxicity[Glutamate Excitotoxicity]
    GR -->|contributes to| Oxidative_Stress[Oxidative Stress]
    GR -->|regulates| HPA_AXIS[HPA_AXIS]
    GR -->|regulates| TUMOR_GROWTH[TUMOR_GROWTH]
    GR -->|interacts| P38[P38]
    GR -->|activates| NLRP3[NLRP3]
    Mifepristone[Mifepristone] -->|inhibits| GR
    RU486[RU486] -->|inhibits| GR
    Corticosterone[Corticosterone] -->|activates| GR
    EIF4G2[EIF4G2] -->|interacts| GR
    FERROPTOSIS[FERROPTOSIS] -->|inhibits| GR
    DNA[DNA] -->|activates| GR
    SKA2[SKA2] -->|regulates| GR
    C9ORF72[C9ORF72] -->|interacts| GR
    AKT[AKT] -->|activates| GR
    GCLC[GCLC] -->|activates| GR

Outgoing (53)

Target	Relation	Type	Str
Glioblastoma	regulates	disease	0.95
Ferroptosis	protects_against	process	0.85
Memory Impairment	mediates	phenotype	0.85
Microglial Activation	regulates	process	0.80
Glutamate Excitotoxicity	contributes_to	process	0.75
Oxidative Stress	contributes_to	process	0.75
HPA_AXIS	regulates	pathway	0.72
frontotemporal dementia	associated_with	disease	0.70
TUMOR_GROWTH	regulates	phenotype	0.64
neuroinflammation	inhibits	disease	0.60
autophagy pathway	participates_in	pathway	0.60
neurodegeneration	regulates	disease	0.60
LDH	biomarker_for	gene	0.60
ferroptosis	participates_in	pathway	0.60
SRRM2	associated_with	gene	0.60
NR3C1	regulates	gene	0.60
NR3C1	associated_with	gene	0.60
NFL	expressed_in	gene	0.60
neurodegeneration	expressed_in	disease	0.60
NFL	causes	gene	0.60
neurodegeneration	associated_with	disease	0.60
frontotemporal dementia	activates	disease	0.60
HSC70	regulates	gene	0.60
GSH	biomarker_for	gene	0.60
NQO1	inhibits	gene	0.60
apoptosis pathway	participates_in	pathway	0.60
neurodegeneration	activates	disease	0.60
HSP70	regulates	gene	0.60
HSPA1A	regulates	gene	0.60
HSPA8	regulates	gene	0.60
SQSTM1	regulates	gene	0.60
STUB1	regulates	gene	0.60
VCP	regulates	gene	0.60
LC3	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
pyroptosis	participates_in	pathway	0.60
oxidative stress response	participates_in	pathway	0.60
glioblastoma	activates	disease	0.60
glioblastoma	expressed_in	disease	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
Alzheimer's disease	associated_with	disease	0.60
NAD	inhibits	gene	0.60
CRISPR-Cas	participates_in	pathway	0.60
microglia	expressed_in	cell_type	0.60
macrophages	expressed_in	cell_type	0.60
ROS	activates	gene	0.60
NR3C2	associated_with	gene	0.60
P38	interacts_with	gene	0.60
RNA	activates	gene	0.60
NLRP3	activates	gene	0.60

Incoming (26)

Source	Relation	Type	Str
RU486	inhibits	drug	0.95
Mifepristone	inhibits	drug	0.95
Corticosterone	activates	compound	0.85
EIF4G2	interacts_with	gene	0.80
FERROPTOSIS	inhibits	process	0.80
ALS	associated_with	gene	0.70
DNA	activates	gene	0.70
SKA2	regulates	gene	0.64
GBM	expressed_in	gene	0.60
AR	inhibits	gene	0.60
ALS	activates	gene	0.60
FSP1	inhibits	gene	0.60
GBM	activates	gene	0.60
BAG3	regulates	gene	0.60
CALR	regulates	gene	0.60
BDNF	expressed_in	gene	0.60
BDNF	regulates	gene	0.60
BDNF	activates	gene	0.60
BECN1	associated_with	gene	0.60
DHFR	inhibits	gene	0.60
DNA	interacts_with	gene	0.60
GFP	interacts_with	gene	0.60
C9ORF72	interacts_with	gene	0.60
AKT	activates	gene	0.60
GCLC	activates	gene	0.60
AGER	associated_with	gene	0.50

Targeting Hypotheses (30)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Metabolic Reprogramming to Reverse Senescence	1.000	-	Senescent cell clearance as neurodegener
Astrocyte-Intrinsic NLRP3 Inflammasome Activation by Alpha-S	0.822	neurodegeneration	What are the mechanisms by which gut mic
TREM2-mTOR Co-Agonism for Metabolic Reprogramming	0.803	neurodegeneration	TREM2 agonism vs antagonism in DAM micro
SASP-Driven Microglial Metabolic Reprogramming in Synaptic P	0.796	neurodegeneration	Senolytic therapy for age-related neurod
Selective APOE4 Degradation via Proteolysis Targeting Chimer	0.795	neurodegeneration	APOE4 structural biology and therapeutic

Integrated Biomarker Panel for Therapeutic Window Identifica	0.784	neurodegeneration	What are the precise temporal dynamics o
Closed-loop tACS targeting entorhinal cortex layer II SST in	0.784	Alzheimer's disease	Circuit-level neural dynamics in neurode
CX3CR1-TREM2 Integration for Synapse Pruning Normalization	0.776	neurodegeneration	TREM2 agonism vs antagonism in DAM micro
TREM2-CSF1R Cross-Talk in Microglial Metabolic Reprogramming	0.748	neurodegeneration	Gene expression changes in aging mouse b
H2: Impaired Autophagy Receptor Recruitment Traps G3BP1 Gran	0.737	neurodegeneration	How do pathological stress granules tran
Metabolic Inflexibility Precedes Transcriptional Reprogrammi	0.735	neurodegeneration	What is the optimal therapeutic window f
SGMS1-Driven Sphingomyelin Accumulation Impairs BACE1 Lysoso	0.734	neurodegeneration	What molecular mechanisms link elevated
Integrated Multi-Analyte CSF Panel Combining YKL-40, sTREM2,	0.730	biomarkers	What biomarkers can reliably detect micr
Synthetic Biology BBB Endothelial Cell Reprogramming	0.727	neurodegeneration	Blood-brain barrier transport mechanisms
TFAM overexpression creates mitochondrial donor-recipient gr	0.725	neurodegeneration	Mitochondrial transfer between astrocyte
Stress Granule Phase Separation Modulators	0.720	neurodegeneration	RNA binding protein dysregulation across
Disease-Associated Microglia Metabolic Reprogramming	0.718	neurodegeneration	Cell type vulnerability in Alzheimers Di
C9orf72 DPRs Impair Autophagy Receptor Docking on Stress Gra	0.717	neurodegeneration	How do pathological stress granules in n
Liquid-to-Solid Transition Pathology Reveals Granule Weak Po	0.710	neurodegeneration	What determines the specificity of RNA-p
Membrane Cholesterol Gradient Modulators	0.708	neurodegeneration	Lipid raft composition changes in synapt
Autophagy-Lysosomal Degradation of IBA1 in Stressed Microgli	0.706	neuroinflammation	What causes IBA1 low/negative microglia
Microglial Purinergic Reprogramming	0.701	neurodegeneration	4R-tau strain-specific spreading pattern
NAD+ Decline and SIRT1 Deficiency Drive Epigenetic Reprogram	0.700	neurodegeneration	What molecular mechanisms drive microgli
m6A RNA Modification as Address Code for Granule Targeting	0.700	neurodegeneration	What determines the specificity of RNA-p
Ataxin-2 Polyglutamine Expansions Hijack G3BP1 to Form Toxic	0.700	neurodegeneration	How do disease-associated mutations in G
Pericyte-targeted senolysis or senomorphic therapy will bene	0.700	neurodegeneration	Does pericyte senescence drive BBB break
Mechanosensitive Ion Channel Reprogramming	0.700	neurodegeneration	Astrocyte reactivity subtypes in neurode
Granzyme B Inhibition with Serpina3n to Preserve Axonal Inte	0.698	neuroimmunology	Do CXCL10-recruited CD8+ T cells provide
EZH2-Mediated H3K27me3 Spreading in Senescent ALS Microglia	0.693	ALS	What are the mechanisms by which microgl
Epigenetic Memory Reprogramming via CRISPRa-Mediated Chromat	0.690	neurodegeneration	CRISPR-based therapeutic approaches for

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (12)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
GWAS of plasma NfL in East Asian cohort	exploratory	Alzheimer's disease	0.950	0.00	human patients - East Asian co	proposed	N/A
GWAS of plasma pTau217 in East Asian cohort	exploratory	Alzheimer's disease	0.950	0.00	human patients - East Asian co	proposed	N/A
Dairy intake and dementia risk in Malmö Diet and Cancer cohort	clinical	Alzheimer's disease	0.950	0.00	Swedish community-based adults	proposed	N/A
GWAS of plasma pTau181 in East Asian cohort	exploratory	Alzheimer's disease	0.950	0.00	human patients - East Asian co	proposed	N/A
GWAS of plasma GFAP in East Asian cohort	exploratory	Alzheimer's disease	0.950	0.00	human patients - East Asian co	proposed	N/A
KEEPS Continuation: Long-term effects of menopausal hormone therapy on	clinical	Alzheimer's disease	0.950	0.00	recently menopausal women with	proposed	N/A
GWAS of composite biomarker score	exploratory	Alzheimer's disease	0.900	0.00	human patients - East Asian co	proposed	N/A
RBG treatment in ApoE-/- atherosclerosis mouse model	validation	atherosclerosis	0.900	0.00	ApoE-/- mice	proposed	N/A
Chi3l1 deletion effects on baseline glial activation in mice	validation	baseline neuroinflammation	0.900	0.00	Chi3l1 knockout mice	proposed	N/A
CHI3L1 variant association with AD progression in human patients	exploratory	Alzheimer's disease	0.850	0.00	human patients	proposed	N/A
s:** - Biochemical binding assays measuring PROTAC selectivity for APO	falsification	Neurodegeneration	0.400	0.50	cell_line	proposed	$100,000
Why Does Amyloid Removal Only Slow Decline 27%? — Mechanistic investig	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$7,100,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Amelioration of Tau and ApoE4-linked glial lipid accumulation and neurodegenerat [PMID:37995685]	Litvinchuk A, Suh JH, Guo JL, Lin K, Dav	Neuron	2024	1
The cell biology of APOE in the brain. [PMID:37805344]	Windham IA, Cohen S	Trends Cell Biol	2024	1
The APOE-R136S mutation protects against APOE4-driven Tau pathology, neurodegene [PMID:37957317]	Maxine R Nelson, Peng Liu, Ayushi Agrawa	Nature neuroscience	2023	1
APOE and Alzheimer's disease: advances in genetics, pathophysiology, and therape [PMID:33340485]	Serrano-Pozo A, Das S, Hyman BT	Lancet Neurol	2021	1
Lysosome-targeting chimaeras for degradation of extracellular proteins. [PMID:32728216]	Banik SM, Pedram K, Wisnovsky S, Ahn G,	Nature	2020	1
Alzheimer Disease: An Update on Pathobiology and Treatment Strategies. [PMID:31564456]	Long JM, Holtzman DM	Cell	2019	1
Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies. [PMID:31367008]	Yamazaki Y, Zhao N, Caulfield TR, Liu CC	Nat Rev Neurol	2019	1
Plasma GFAP outperforms CSF GFAP in detecting amyloid pathology and is associate [PMID:41905188]	Cetindag AC, Schipke CG, Esselmann H, Kr	The journal of prevention of A	2026	0
Perioperative polygenic and APOE-based genetic risk assessment for neurocognitiv [PMID:40562635]	Thedim M, Hu J, Maher M, Wiener-Kronish	Br J Anaesth	2026	0
Increased genetic protection against Alzheimer's disease in centenarians. [PMID:40615639]	Bae H, Song Z, Ali A, Sasaki T, Tesi N e	Geroscience	2026	0
Monocyte LOXHD1 and RHOB Expression Predictive of Progressive Systemic Sclerosis [PMID:40771159]	Padilla CM, Lafyatis R, Gibson KF, Morse	Arthritis Care Res (Hoboken)	2026	0
Integrative machine learning approach to risk prediction for dementia and Alzhei [PMID:40864401]	Stern A, Linial M	Geroscience	2026	0
Adipose Tissue Macrophage-Derived Proplatelet Basic Protein Exacerbates Psoriasi [PMID:40886963]	Zhu L, Du L, Wu J, Ding D, Wang J et al.	J Invest Dermatol	2026	0
Restoration of p53 mRNA combined with BRD4 silencing by brain targeted nanocapsu [PMID:41101204]	Sang Y, Cao Y, Li S, Quan Y, Wang S et a	Biomaterials	2026	0
Targeting KAT8 alleviates vascular senescence by modulating the INHBA/TGF-β path [PMID:41445196]	Lin Z, Xiong J, Zhang F, Zhang H, Zhu M	Mol Ther	2026	0
Obstructive sleep apnea, biomarker profiles, and clinical progression in Parkins [PMID:41499940]	Zhu S, An D, Liu X	Sleep Med	2026	0
Menopause, cognition, and Alzheimer's disease risk. [PMID:41531227]	Samudra N, Vemuri M, Weitlauf J	Curr Opin Obstet Gynecol	2026	0
Peripheral cancer attenuates amyloid pathology in Alzheimer's disease via cystat [PMID:41576952]	Li X, Tang X, Zeng J, Duan L, Hou Z et a	Cell	2026	0
SuPAR levels are increased in sera of euthymic patients with bipolar disorder an [PMID:41605346]	Kök Kendirlioğlu B, Çörekli Kaymakçı E,	J Affect Disord	2026	0
Chitinase-like Proteins YKL-40 and YKL-39 in Colorectal Cancer. [PMID:41677627]	Ivanova T, Kazakova M, Dikov D, Dzhambov	Cells	2026	0

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning GR in their description or question text

Integrated Biomarker Panel for Therapeutic Window Identification

Score: 0.784 · neurodegeneration · 2026-04-15

## Mechanistic Overview Integrated Biomarker Panel for Therapeutic Window Identification starts from the claim that modu

Closed-loop tACS targeting entorhinal cortex layer II SST interneurons to activa

Score: 0.784 · Alzheimer's disease · 2026-04-05

## Mechanistic Overview Closed-loop tACS targeting entorhinal cortex layer II SST interneurons to activate AMPK-autophag

CX3CR1-TREM2 Integration for Synapse Pruning Normalization

Score: 0.776 · neurodegeneration · 2026-04-16

## Mechanistic Overview CX3CR1-TREM2 Integration for Synapse Pruning Normalization starts from the claim that modulating

TREM2-CSF1R Cross-Talk in Microglial Metabolic Reprogramming

Score: 0.748 · neurodegeneration · 2026-04-12

**Molecular Mechanism and Rationale** The TREM2-CSF1R metabolic cross-talk hypothesis centers on the intricate molecula

H2: Impaired Autophagy Receptor Recruitment Traps G3BP1 Granules

Score: 0.737 · neurodegeneration · 2026-04-22

**Molecular Mechanism and Rationale** The central molecular mechanism underlying this hypothesis involves the intricate

Metabolic Inflexibility Precedes Transcriptional Reprogramming (NAD+/SIRT3 Axis)

Score: 0.735 · neurodegeneration · 2026-04-22

**Molecular Mechanism and Rationale** The NAD+/SIRT3 axis represents a critical regulatory hub controlling mitochondria

SGMS1-Driven Sphingomyelin Accumulation Impairs BACE1 Lysosomal Degradation via

Score: 0.734 · neurodegeneration · 2026-04-15

## Mechanistic Overview SGMS1-Driven Sphingomyelin Accumulation Impairs BACE1 Lysosomal Degradation via Autophagosome-Ly

Integrated Multi-Analyte CSF Panel Combining YKL-40, sTREM2, and Neurogranin

Score: 0.730 · biomarkers · 2026-04-22

## Mechanistic Overview Integrated Multi-Analyte CSF Panel Combining YKL-40, sTREM2, and Neurogranin starts from the cla

Synthetic Biology BBB Endothelial Cell Reprogramming

Score: 0.727 · neurodegeneration · 2026-04-02

## Mechanistic Overview Synthetic Biology BBB Endothelial Cell Reprogramming starts from the claim that modulating TFR1,

TFAM overexpression creates mitochondrial donor-recipient gradients for directed

Score: 0.725 · neurodegeneration · 2026-04-02

## Mechanistic Overview TFAM overexpression creates mitochondrial donor-recipient gradients for directed organelle traff

Stress Granule Phase Separation Modulators

Score: 0.720 · neurodegeneration · 2026-04-02

## Mechanistic Overview Stress Granule Phase Separation Modulators starts from the claim that modulating G3BP1 within th

Disease-Associated Microglia Metabolic Reprogramming

Score: 0.718 · neurodegeneration · 2026-04-12

## Mechanistic Overview Disease-Associated Microglia Metabolic Reprogramming starts from the claim that modulating TREM2

C9orf72 DPRs Impair Autophagy Receptor Docking on Stress Granules

Score: 0.717 · neurodegeneration · 2026-04-22

## **Molecular Mechanism and Rationale** The hexanucleotide repeat expansion (GGGGCC) in the C9orf72 gene represents th

Liquid-to-Solid Transition Pathology Reveals Granule Weak Points

Score: 0.710 · neurodegeneration · 2026-04-21

## **Molecular Mechanism and Rationale** The liquid-to-solid phase transition of ribonucleoprotein (RNP) granules repre

Membrane Cholesterol Gradient Modulators

Score: 0.708 · neurodegeneration · 2026-04-02

## Mechanistic Overview Membrane Cholesterol Gradient Modulators starts from the claim that modulating ABCA1/LDLR/SREBF2

GR

Understanding Entity Pages

Wiki Pages (20)

RASGRP1 Gene

RASGRF1 — Ras Protein-Specific Guanine Nucleotide-Releasing Factor 1

GRIK3 - Glutamate Receptor Kainate Type Subunit 3

GRIN1 — NMDA Receptor Subunit 1

GRIN2D Protein

GRN Progranulin FTD Causal Chain

GRID1 — Glutamate Ionotropic Receptor Delta Type Subunit 1

GAB2 — GRB2 Associated Binding Protein 2

GRK6 Gene

GRK5 — G Protein-Coupled Receptor Kinase 5

GRK3 — G Protein-Coupled Receptor Kinase 3

GRIN2A Gene

GRIA3 Gene

GRIN2A Protein

GRM1 Gene

GIGYF2 — GRB10 Interacting GYF Protein 2

GRM5 Gene

RASGRF2

CGRP Receptor Modulators in Neurodegeneration

GRID2 — Glutamate Ionotropic Receptor Delta Type Subunit 2