gene

GSDME

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GSDME: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

262Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

GSDME (Gasdermin E/DFNA5) encodes a pore-forming protein executing pyroptosis, implicated in neuronal death in AD, PD, ALS, and stroke.

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🧬 Gene Info

Gene Symbol	GSDME
Full Name	Gasdermin E
Aliases	Gasdermin E/DFNA5
Chromosome	7p15.3
Function	Caspase-3 cleavage: Unlike GSDMD, GSDME is cleaved by executioner caspase-3
Primary Expression	cochlea, brain, and other tissues
Molecular Weight	55 kDa
Amino Acids	496 aa
Exons	12
Pathways	Pyroptosis
UniProt ID	[O60443](https://www.uniprot.org/uniprotkb/O60443)
GeneCards	GSDME
Human Protein Atlas	GSDME
N-terminal domain (residues 1-275)	The pore-forming region. This domain is auto-inhibited by the C-terminal domain in the full-length protein but becomes capable of oligomerizing into pores (10-20 nm diameter) upon cleavage[@xia2021].
C-terminal domain (residues 276-496)	The regulatory region that maintains the protein in an inactive conformation. C-terminal domain removal is both necessary and sufficient for pore formation.
Associated Diseases	Amyotrophic Lateral Sclerosis, Axon Loss, Cancer, Frontotemporal Dementia, Melanoma, Pyroptosis
Known Drugs/Compounds	Celastrol, XHP
Interactions	AKT, ALS, AMPK, amyotrophic lateral sclerosis, AMYOTROPHIC LATERAL SCLEROSIS, AND
KG Connections	262 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

GSDME — Gasdermin E

gene · 1996 words

→

GSDME Protein — Gasdermin E

protein · 635 words

→

Pathway Diagram

graph TD
    GSDME["GSDME"]
    Cancer{"Cancer"}
    GSDME -->|"activates"| Cancer
    Ms{"Ms"}
    GSDME -->|"activates"| Ms
    Tumor{"Tumor"}
    GSDME -->|"activates"| Tumor
    GSDME -->|"inhibits"| Cancer
    Als{"Als"}
    GSDME -->|"activates"| Als
    GSDME -->|"therapeutic target"| Ms
    Atherosclerosis{"Atherosclerosis"}
    GSDME -->|"activates"| Atherosclerosis
    Cardiovascular{"Cardiovascular"}
    GSDME -->|"regulates"| Cardiovascular
    GSDME -->|"regulates"| Atherosclerosis
    Leukemia{"Leukemia"}
    GSDME -->|"activates"| Leukemia
    Carcinoma{"Carcinoma"}
    GSDME -->|"inhibits"| Carcinoma
    ALS{"ALS"}
    GSDME -->|"degrades"| ALS
    CALR["CALR"]
    CALR -->|"activates"| GSDME
    NLRP3["NLRP3"]
    NLRP3 -->|"expressed in"| GSDME
    NLRP3 -->|"regulates"| GSDME
    GENES["GENES"]
    GENES -->|"activates"| GSDME
    CD8["CD8"]
    CD8 -->|"activates"| GSDME
    PYROPTOSIS["PYROPTOSIS"]
    PYROPTOSIS -->|"activates"| GSDME
    PYROPTOSIS -->|"inhibits"| GSDME
    PJA1["PJA1"]
    PJA1 -->|"inhibits"| GSDME
    PHAGOCYTOSIS["PHAGOCYTOSIS"]
    PHAGOCYTOSIS -->|"activates"| GSDME
    STAT3["STAT3"]
    STAT3 -->|"activates"| GSDME
    AND["AND"]
    AND -->|"activates"| GSDME
    CANCER["CANCER"]
    CANCER -->|"activates"| GSDME
    style GSDME fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (195)

Target	Relation	Type	Str
PYROPTOSIS	activates	gene	1.00
Pyroptosis	activates	pathway	1.00
pyroptosis	associated_with	process	0.98
Tumor	activates	disease	0.95
Tumor Suppressor	associated_with	biomarker	0.95
Cancer	activates	disease	0.95
Mitochondrial Depolarization	mediates	process	0.95
Neuron	expressed_in	cell_type	0.95
Mitochondrial Damage	mediates	process	0.95
Als	activates	disease	0.95
Anti-Tumor Immunity	activates	process	0.95
pyroptosis	mediates	process	0.95
Tumor Growth	inhibits	phenotype	0.95
Axon Loss	involved_in	phenotype	0.90
Pyroptosis	mediates	process	0.90
Amyotrophic Lateral Sclerosis	associated_with	disease	0.90
Axon Loss	causes	phenotype	0.90
Natural Killer Cells	modulates	cell_type	0.85
CD8+ T Lymphocyte Infiltration	associated_with	process	0.85
CD8+ T Lymphocytes	modulates	cell_type	0.85
Neurite Retraction	mediates	phenotype	0.85
Mitochondrial Depolarization	associated_with	process	0.85
Phagocytosis	associated_with	process	0.85
Cancer	associated_with	disease	0.85
Frontotemporal Dementia	associated_with	disease	0.85
Macrophage Phagocytosis	associated_with	process	0.85
Tumor-Associated Macrophages	modulates	cell_type	0.80
pyroptosis	participates_in	pathway	0.80
mitochondrial damage	causes	process	0.80
ROS	activates	gene	0.80
CANCER	activates	gene	0.80
GENES	activates	gene	0.70
UBIQUITIN	activates	gene	0.70
CYTOKINES	activates	gene	0.70
CD8	activates	gene	0.70
STING	activates	gene	0.70
apoptosis pathway	participates_in	pathway	0.70
oxidative stress response	participates_in	pathway	0.70
Apoptosis	activates	pathway	0.70
pyroptosis	activates	process	0.70
Inflammasome	activates	pathway	0.70
Carcinoma	activates	disease	0.65
Renal Cell Carcinoma	activates	disease	0.65
Osteoporosis	treats	disease	0.65
Lung Cancer	activates	disease	0.65
Melanoma	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Inflammation	regulates	disease	0.65
Melanoma	associated_with	disease	0.65
ALS	degrades	disease	0.65

Incoming (67)

Source	Relation	Type	Str
CASP3	activates	gene	0.95
p53	activates	protein	0.95
XHP	activates	drug	0.95
Celastrol	activates	compound	0.95
NLRP3-Caspase inflammatory signaling	activates	pathway	0.92
CASP3	associated_with	protein	0.90
GRANZYME B	cleaves	enzyme	0.90
GRZB	cleaves	enzyme	0.90
reactive oxygen species	cleaves	process	0.88
STAT3	regulates	entity	0.85
TDP-43	activates	protein	0.85
JNK	therapeutic_target	gene	0.60
SOD1	associated_with	gene	0.60
AKT	activates	gene	0.60
GSDMD	associated_with	gene	0.60
APOPTOSIS	associated_with	gene	0.60
CD8	activates	gene	0.60
STING	activates	gene	0.60
ROS	activates	gene	0.60
CANCER	inhibits	gene	0.60
CANCER	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
NLRP3	expressed_in	gene	0.60
NLRP3	regulates	gene	0.60
STAT3	activates	gene	0.60
PJA1	inhibits	gene	0.60
PYROPTOSIS	causes	gene	0.60
CALR	activates	gene	0.60
APOPTOSIS	therapeutic_target	gene	0.60
CYTOKINES	activates	gene	0.60
AND	associated_with	gene	0.60
PYROPTOSIS	regulates	gene	0.60
MITOCHONDRIA	activates	gene	0.60
ERK	associated_with	gene	0.60
ROS	therapeutic_target	gene	0.60
INFLAMMATION	regulates	gene	0.60
APOPTOSIS	expressed_in	gene	0.60
CANCER	associated_with	entity	0.60
ALS	activates	entity	0.60
FTD	activates	entity	0.60
ALS	protects_against	entity	0.60
GASDERMIN	activates	gene	0.60
GASDERMIN	associated_with	gene	0.60
AND	inhibits	gene	0.60
NEURODEGENERATION	activates	gene	0.60
DEMENTIA	activates	gene	0.60
MITOCHONDRIAL DYSFUNCTION	activates	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	activates	gene	0.60
MOTOR NEURONS	protects_against	gene	0.60
AXON	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning GSDME in their description or question text

No additional research found