concept

SGLT2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SGLT2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

22Connections

0Hypotheses

0Analyses

13Outgoing

9Incoming

0Experiments

0Debates

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💡 Concept Info

Name	SGLT2
Key Genes/Proteins	FUNDC1, HK2, HMGCS2, LDH, mTOR, MTOR
Related Diseases	neurodegeneration, Parkinson's disease
Related Pathways	ferroptosis, lipid metabolism, oxidative stress response

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    SGLT2[SGLT2]
    SGLT2 -->|regulates| Glucose_Reabsorption[Glucose Reabsorption]
    SGLT2 -.biomarker for.-> type_2_diabetes[type 2 diabetes]
    SGLT2 -->|involved_in| glucose_metabolism[glucose metabolism]
    SGLT2 -->|regulates| MTOR[MTOR]
    SGLT2 -->|regulates| mTOR[mTOR]
    SGLT2 -->|participates in| ferroptosis[ferroptosis]
    SGLT2 -->|inhibits| VDAC1[VDAC1]
    SGLT2 -->|inhibits| neurodegeneration[neurodegeneration]
    SGLT2 -->|participates in| oxidative_stress_response[oxidative stress response]
    SGLT2 -->|participates in| lipid_metabolism[lipid metabolism]
    Gliflozins[Gliflozins] -->|inhibits| SGLT2
    Glucose[Glucose] -->|upregulates| SGLT2
    HK2[HK2] -->|activates| SGLT2
    LDH[LDH] -->|activates| SGLT2
    PGC1A[PGC1A] -->|activates| SGLT2
    PLIN2[PLIN2] -->|activates| SGLT2
    PPARA[PPARA] -->|activates| SGLT2
    FUNDC1[FUNDC1] -->|inhibits| SGLT2

Outgoing (13)

Target	Relation	Type	Str
Glucose Reabsorption	regulates	process	0.95
glucose metabolism	involved_in	process	0.90
type 2 diabetes	biomarker_for	disease	0.90
MTOR	regulates	protein	0.70
mTOR	regulates	protein	0.70
oxidative stress response	participates_in	pathway	0.60
lipid metabolism	participates_in	pathway	0.60
neurodegeneration	inhibits	disease	0.60
ferroptosis	participates_in	pathway	0.60
VDAC1	inhibits	gene	0.60
senescence	participates_in	pathway	0.60
Parkinson's disease	inhibits	disease	0.60
stem cells	expressed_in	cell_type	0.55

Incoming (9)

Source	Relation	Type	Str
Gliflozins	inhibits	drug	0.95
Glucose	upregulates	compound	0.90
HK2	activates	gene	0.60
LDH	activates	gene	0.60
PGC1A	activates	gene	0.60
PLIN2	activates	gene	0.60
PPARA	activates	gene	0.60
FUNDC1	inhibits	gene	0.60
HMGCS2	associated_with	gene	0.35

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SGLT2 in their description or question text

No additional research found