concept

SYNAPTIC PLASTICITY

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SYNAPTIC PLASTICITY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1727Connections

2Hypotheses

1Analyses

50Outgoing

50Incoming

10Experiments

2Debates

Summary

SYNAPTIC PLASTICITY is a concept in neurodegeneration research. Key relationships include: co discussed, associated with, regulates. Associated with ALZHEIMER, ALZHEIMER'S, ALZHEIMER'S DISEASE. Connected to 54 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	SYNAPTIC PLASTICITY
Key Genes/Proteins	ALPHA-SYNUCLEIN, AMYLOID, AMYLOID-BETA
Related Diseases	ACETYLCHOLINE, AGING, ALS, ALZHEIMER, ALZHEIMER'S DISEASE

Pathway Diagram

graph TD
    SYNAPTIC_PLASTICITY["SYNAPTIC PLASTICITY"]
    SYNAPTIC_PLASTICITY -->|"interacts"| Complement["Complement"]
    SYNAPTIC_PLASTICITY -->|"interacts"| Nf__b["Nf-Kappab"]
    BDNF["BDNF"] -->|"regulates"| SYNAPTIC_PLASTICITY
    physical_exercise["physical exercise"] -->|"regulates"| SYNAPTIC_PLASTICITY
    APOE4["APOE4"] -->|"inhibits"| SYNAPTIC_PLASTICITY
    TrkB_FL["TrkB-FL"] -->|"regulates"| SYNAPTIC_PLASTICITY
    PI3K_AKT["PI3K/AKT"] -->|"regulates"| SYNAPTIC_PLASTICITY
    PI3K_AKT_pathway["PI3K/AKT pathway"] -->|"regulates"| SYNAPTIC_PLASTICITY
    SXD["SXD"] -->|"activates"| SYNAPTIC_PLASTICITY
    epigenetic_alterations["epigenetic alterations"] -->|"regulates"| SYNAPTIC_PLASTICITY

Outgoing (201)

Target	Relation	Type	Str
Cognitive Impairment	associated_with	disease	0.90
hippocampus	active_in	brain_region	0.90
astrocytes	active_in	cell_type	0.90
Sustained Antidepressant Effects	causes	phenotype	0.90
neurons	active_in	cell_type	0.90
learning and memory	mediates	process	0.90
Drug-Resistant Epilepsy	associated_with	disease	0.85
Chronic Inflammatory Pain-Related Depression	involved_in	disease	0.85
Depression	involved_in	disease	0.85
Depressive Behavior	mediates	phenotype	0.85
cognitive function	mediates	phenotype	0.84
Insomnia	associated_with	disease	0.80
microglia	active_in	cell_type	0.80
Depression-Like Phenotype	protects_against	phenotype	0.80
unfolded protein response	crosstalk_with	pathway	0.80
calcium signaling	mediates	process	0.70
dentate gyrus	active_in	brain_region	0.70
pyramidal neurons	active_in	cell_type	0.70
neural stem cells	active_in	cell_type	0.70
oligodendrocytes	active_in	cell_type	0.70
cortex	active_in	brain_region	0.70
Major depressive disorder	associated_with	disease	0.70
DEPRESSION	treats	disease	0.70
interneurons	active_in	cell_type	0.70
cerebral cortex	active_in	brain_region	0.70
EXCITOTOXICITY	causes	phenotype	0.70
LRP1	protects_against	gene	0.70
NMDAR	activates	gene	0.70
CYP46A1	stabilizes	gene	0.70
CYP46A1	treats	gene	0.70
CYP46A1	protects_against	gene	0.70
CYP46A1	inhibits	gene	0.70
AGING	stabilizes	phenotype	0.70
SEMAGLUTIDE	activates	drug	0.65
COGNITIVE DECLINE	regulates	phenotype	0.65
CA1	causes	brain_region	0.65
MINOCYCLINE	activates	drug	0.65
CREB1	interacts_with	gene	0.65
BDNF	treats	gene	0.65
BDNF	targets	gene	0.65
LONG-TERM DEPRESSION	treats	phenotype	0.60
GABAergic neurons	active_in	cell_type	0.60
phagocytosis	mediates	process	0.60
amygdala	active_in	brain_region	0.60
amyloid aggregation	mediates	process	0.60
synaptic pruning	mediates	process	0.60
VGLUT1	activates	gene	0.60
brainstem	active_in	brain_region	0.60
TRKB	activates	gene	0.60
LONG-TERM DEPRESSION	activates	phenotype	0.60

Incoming (1526)

Source	Relation	Type	Str
Neuroinflammation	activates	disease	1.00
Inflammation	activates	disease	1.00
ALZHEIMER'S DISEASE	activates	gene	1.00
NEUROINFLAMMATION	activates	gene	1.00
Alzheimer	therapeutic_target	disease	1.00
OXIDATIVE STRESS	activates	gene	1.00
NEURODEGENERATION	activates	gene	1.00
Alzheimer	activates	disease	1.00
Neurodegeneration	activates	disease	1.00
Als	activates	disease	1.00
ALZHEIMER'S DISEASE	therapeutic_target	gene	1.00
ALZHEIMER	therapeutic_target	gene	1.00
Als	regulates	disease	1.00
ALZHEIMER	activates	gene	1.00
BDNF	activates	gene	1.00
TRKB	activates	gene	1.00
INFLAMMATION	activates	gene	1.00
Als	therapeutic_target	disease	1.00
NEURODEGENERATION	regulates	gene	1.00
EXERCISE	activates	gene	1.00
AKT	activates	gene	1.00
AUTOPHAGY	activates	gene	1.00
RLN1	regulates	protein	0.95
Astrocytes	modulates	cell_type	0.95
Calcium Homeostasis	regulates	process	0.95
Channelrhodopsin-2	inhibits	protein	0.95
RLN	regulates	protein	0.95
BDNF	associated_with	protein	0.95
Microglia	regulates	cell_type	0.95
Neurodegeneration	regulates	disease	0.95
NEURON	activates	cell_type	0.95
WNT	regulates	pathway	0.95
Cytoskeleton Disruption	associated_with	mechanism	0.95
RELN	regulates	entity	0.95
IGF2	mediates	protein	0.95
Autophagy	involved_in	process	0.95
Complement System	involved_in	pathway	0.95
APP	participates_in	gene	0.90
Astrocytes	involved_in	cell_type	0.90
REELIN	regulates	protein	0.90
BDNF	regulates	protein	0.90
Ionotropic Astrocytes	suppresses	cell_type	0.90
BDNF	mediates	protein	0.90
NMDA receptor	activates	receptor	0.90
RAB3B	involved_in	gene	0.90
Physical Exercise	modulates	process	0.90
Activated Microglia	modulates	cell_type	0.90
Methamphetamine	causes	drug	0.90
Synaptic Pruning	regulates	process	0.90
APOE	associated_with	gene	0.90

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Sleep Spindle-Synaptic Plasticity Enhancement	0.721	neurodegeneration	Sleep disruption as cause and consequenc
Polycomb-to-Trithorax Switch at Synaptic Plasticity Genes	0.530	neurodegeneration	Comparative epigenetic signatures: DNA m

Mentioning Analyses (1)

Scientific analyses that reference this entity

Investigate mechanisms of epigenetic reprogramming in aging neurons

neurodegeneration | 2026-04-10 | 0 hypotheses

Experiments (10)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Brain Connectivity-Targeted tACS Trial in Early AD	clinical	Alzheimer's Disease	0.509	0.50	human postmortem brain tissue	proposed	$520,000
s:** - Test whether HCN1 knockout specifically in EC layer II accelera	falsification	Alzheimer's Disease	0.400	0.50	cell_line	proposed	$80,000
tACS Connectivity Trial in Early Alzheimer's	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000
Brain Connectivity-Targeted tACS Trial in Early AD	clinical	Alzheimer's Disease	0.400	0.50	mouse	proposed	$730,000
DLB Cognitive Fluctuation Mechanism Experiment	clinical	Neurodegeneration	0.400	0.50	human	proposed	$6,550,000
Migraine Cortical Hyperexcitability and Alzheimer's Disease Risk: Long	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000
Neural Oscillation Dysfunction Validation in Parkinson's Disease	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$5,460,000
Non-Motor Symptom Progression in Parkinson's Disease — Mechanisms and	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$5,460,000
Sleep and Circadian Dysfunction as Driver of Neurodegeneration	clinical	Neurodegeneration	0.400	0.50	human	proposed	$5,460,000
Sleep Disruption and Alzheimer's Disease — mechanism and intervention	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Effects of caffeine on sleep and cognition. [PMID:21531247]	Snel J, Lorist MM	Prog Brain Res	2011	1
Functional dissection of Timekeeper (Tik) implicates opposite roles for CK2 and [PMID:19536808]	Kunttas-Tatli E, Bose A, Kahali B, Bisho	Genesis	2009	1
CI-994 is a dual modulator of class I HDACs and Wnt/β-catenin signaling for the [PMID:41654970]	Lu W, Kawatani K, Ren Y	Alzheimers Res Ther	2026	0
Molecular brake on firing pattern transitions in MHbChAT neurons to mediate nico [PMID:41903536]	Zheng ZW, Min PX, Luo YL, Mao XF, Zhang	Neuron	2026	0
Estradiol modulates neuronal network hyperexcitability in select NDD risk genes. [PMID:41757108]	Pruitt A, Yang L, Lee S, Balafkan N, Sea	bioRxiv : the preprint server	2026	0
Vitamin D supplementation and COVID-19 risk: a population-based, cohort study. [PMID:34273098]	["Oristrell J", "Oliva J", "Casado E", "	Journal of endocrinological in	2022	0
Intracellular calcium homeostasis and its dysregulation underlying epileptic sei [PMID:36403388]	Zhou X, Chen Z, Xiao L, Zhong Y, Liu Y,	Seizure	2022	0
Homeostatic plasticity and burst activity are mediated by hyperpolarization-acti [PMID:33547341]	Rátkai A, Tárnok K, Aouad HE, Micska B,	Scientific reports	2021	0
Machine learning reveals bilateral distribution of somatic L1 insertions in huma [PMID:33432196]	["Zhu X", "Zhou B", "Pattni R", "Gleason	Nature neuroscience	2021	0
Cryo-EM structures of full-length Tetrahymena ribozyme at 3.1 Å resolution. [PMID:34381213]	["Su Z", "Zhang K", "Kappel K", "Li S",	Nature	2021	0
Prevalence and follow-up of potentially inappropriate medication and potentially [PMID:32641251]	["van Loveren F", "van Berlo-van de Laar	Journal of geriatric oncology	2021	0
COPD exacerbations: finally, a more than ACCEPTable risk score. [PMID:32178778]	Surya P Bhatt	The Lancet. Respiratory medici	2020	0
Neuronal Cav3 channelopathies: recent progress and perspectives. [PMID:32638069]	Lory P, Nicole S, Monteil A	Pflugers Archiv : European jou	2020	0
Single-cell epigenomic analyses implicate candidate causal variants at inherited [PMID:33106633]	["Corces M", "Shcherbina A", "Kundu S",	Nature genetics	2020	0
Reciprocal associations between depression, anxiety and work-related injury. [PMID:31685530]	["Gerasimaviciute V", "B\u00fcltmann U",	Injury prevention : journal of	2020	0
Editorial [PMID:30896375]	Graham John	Cochlear Implants Internationa	2019	0
On-surface synthesis of planar dendrimers via divergent cross-coupling reaction. [PMID:31160575]	["Li D", "Li S", "Xie Y", "Hua X", "Long	Nature communications	2019	0
STAT4 Directs a Protective Innate Lymphoid Cell Response to Gastrointestinal Inf [PMID:31562212]	["Dulson S", "Watkins E", "Crossman D",	Journal of immunology (Baltimo	2019	0
Epidemiology of Bradykinin-mediated angioedema: a systematic investigation of ep [PMID:29728119]	["Ayg\u00f6ren-P\u00fcrs\u00fcn E", "Mag	Orphanet journal of rare disea	2018	0
Predictors of Extended Length of Hospital Stay Following Surgical Repair of Cong [PMID:30171266]	["Azhar A", "Aljefri H"]	Pediatric cardiology	2018	0

Debates (2)

Multi-agent debates referencing this entity

Investigate mechanisms of epigenetic reprogramming in aging neurons [TARGET_ART

closed · Rounds: 0 · Score: 0.50 · 2026-04-21

Investigate mechanisms of epigenetic reprogramming in aging neurons

closed · Rounds: 0 · Score: 0.56 · 2026-04-21

Related Research

Hypotheses and analyses mentioning SYNAPTIC PLASTICITY in their description or question text

No additional research found