gene

VGLUT1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about VGLUT1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

204Connections

0Hypotheses

6Analyses

50Outgoing

50Incoming

0Experiments

8Debates

Summary

The SLC17A7 (VGLUT1) gene encodes vesicular glutamate transporter 1, essential for excitatory neurotransmission in the cerebral cortex and hippocampus. This page covers its role in synaptic function, expression patterns, and implications for neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, and epilepsy.

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🧬 Gene Info

Gene Symbol	VGLUT1
Aliases	Vesicular Glutamate Transporter 1
Chromosome	19q13.33
Primary Expression	glutamatergic (excitatory) neurons
Molecular Weight	62 kDa
Amino Acids	560 aa
Exons	12
Pathways	Amyloid, Apoptosis
Ensembl ID	ENSG00000177656
GeneCards	VGLUT1
Human Protein Atlas	VGLUT1
Cerebral cortex	Highest in layers II-III and V (pyramidal neurons)
Hippocampus	CA1-CA3 pyramidal cells, dentate gyrus granule cells
Olfactory bulb	Mitral and tufted cells
Thalamus	Specific relay nuclei
Associated Diseases	epilepsy, excitatory neuron loss, ISCHEMIA, neurodegeneration
Interactions	Akt, ALZHEIMER, ALZHEIMER'S DISEASE, AND, APOE, APOE3
KG Connections	204 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (5)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    VGLUT1["VGLUT1"]
    Ms{"Ms"}
    VGLUT1 -->|"activates"| Ms
    LAMP1["LAMP1"]
    VGLUT1 -->|"associated with"| LAMP1
    Apoptosis(["Apoptosis"])
    VGLUT1 -->|"activates"| Apoptosis
    Phagocytosis(["Phagocytosis"])
    VGLUT1 -->|"activates"| Phagocytosis
    neurodegeneration["neurodegeneration"]
    VGLUT1 -->|"implicated in"| neurodegeneration
    style VGLUT1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (137)

Target	Relation	Type	Str
SLC17A7	encoded_by	gene	0.99
SYNAPTIC_VESICLE	localized_to	structure	0.95
V-ATPASE	depends_on	protein	0.85
excitatory neuron loss	causes	phenotype	0.70
TRORILUZOLE	pharmacological_target	drug	0.70
C1Q deposition susceptibility	associated_with	mechanism	0.70
Als	inhibits	disease	0.65
Alzheimer	biomarker_for	disease	0.65
Neurodegeneration	activates	disease	0.65
Alzheimer	activates	disease	0.65
Alzheimer	regulates	disease	0.65
Diabetes	inhibits	disease	0.65
Ischemia	activates	disease	0.65
Epilepsy	inhibits	disease	0.65
Epilepsy	expressed_in	disease	0.65
Multiple Sclerosis	activates	disease	0.65
ALS	inhibits	disease	0.65
ALS	regulates	disease	0.65
Autoimmune	regulates	disease	0.65
Aging	activates	disease	0.65
Ms	activates	disease	0.65
oligodendrocytes	expressed_in	cell_type	0.60
neurons	expressed_in	cell_type	0.60
Synaptic Plasticity	activates	pathway	0.60
Aβ	biomarker_for	protein	0.60
Raf	expressed_in	protein	0.60
Phagocytosis	activates	pathway	0.60
Neuron	regulates	cell_type	0.60
SYNAPSE	activates	gene	0.60
Neuron	activates	cell_type	0.60
Stem Cell	regulates	cell_type	0.60
NEURON	activates	gene	0.60
Epigenetic	activates	pathway	0.60
Aβ	activates	protein	0.60
Nmda Receptor	transports	protein	0.60
epilepsy	activates	disease	0.60
neurodegeneration	activates	disease	0.60
Apoptosis	activates	pathway	0.60
Exocytosis	expressed_in	pathway	0.60
TAU	activates	gene	0.60
APOE	activates	gene	0.60
APOE4	activates	gene	0.60
VEGF	activates	gene	0.60
GFAP	activates	gene	0.60
EPILEPSY	inhibits	gene	0.60
ALZHEIMER	regulates	gene	0.60
APOPTOSIS	regulates	gene	0.60
PRESENILIN	regulates	gene	0.60
EPILEPSY	expressed_in	gene	0.60
Apoptosis	regulates	pathway	0.60

Incoming (67)

Source	Relation	Type	Str
EPILEPSY	expressed_in	gene	0.60
COMPLEMENT	expressed_in	gene	0.60
AND	expressed_in	gene	0.60
SLC17A6	activates	gene	0.60
BDNF	inhibits	gene	0.60
ALZHEIMER	activates	gene	0.60
synaptic plasticity	activates	process	0.60
MAP	inhibits	gene	0.60
SLC17A7	activates	gene	0.60
KDM6B	activates	gene	0.60
AND	activates	gene	0.60
AND	inhibits	gene	0.60
INSULIN RESISTANCE	associated_with	gene	0.60
ALZHEIMER	regulates	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
APOPTOSIS	regulates	gene	0.60
NEURON	activates	gene	0.60
MAPT	regulates	gene	0.60
BACE1	regulates	gene	0.60
SYNAPTOPHYSIN	activates	gene	0.60
VGLUT2	expressed_in	gene	0.60
APP	regulates	gene	0.60
APOER2	activates	gene	0.60
AMYLOID	regulates	gene	0.60
EPILEPSY	inhibits	gene	0.60
SLC17A7	inhibits	gene	0.60
VGLUT2	associated_with	gene	0.60
PSD95	regulates	gene	0.60
APOE	activates	gene	0.60
APOE4	activates	gene	0.60
VEGF	activates	gene	0.60
APOE3	activates	gene	0.60
SYNAPTOPHYSIN	expressed_in	gene	0.60
GFAP	activates	gene	0.60
TAU	activates	gene	0.60
MMP9	expressed_in	gene	0.60
SYNAPSE	activates	gene	0.60
AXON	regulates	gene	0.60
AND	regulates	gene	0.60
MYELIN	regulates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
ALZHEIMER	biomarker_for	gene	0.60
GABA	biomarker_for	gene	0.60
AND	biomarker_for	gene	0.60
ALZHEIMER'S DISEASE	biomarker_for	gene	0.60
AMYLOID	biomarker_for	gene	0.60
PRESENILIN	regulates	gene	0.60
oxidative stress	co_mentioned	process	0.55
SLC17A7	associated_with	gene	0.55
TNF	activates	gene	0.55

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (6)

Scientific analyses that reference this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (8)

Multi-agent debates referencing this entity

Related Research

Hypotheses and analyses mentioning VGLUT1 in their description or question text

No additional research found

VGLUT1

Understanding Entity Pages

Summary

Wiki Pages (5)

vglut1

VGLUT1 Protein (SLC17A7)

VGLUT1 Gene

SLC17A1 — Solute Carrier Family 17 Member 1 (VGLUT1)

VGLUT1 Protein

Pathway Diagram

Outgoing (137)

Incoming (67)

Targeting Hypotheses (0)

Mentioning Analyses (6)

Do these mechanistic hypotheses from the SEA-AD Atlas bundle explain layer-speci

Do these mechanistic hypotheses explain layer-specific synaptic vulnerability in

Mechanistic validation of SEA-AD differential expression hypotheses: Complement

Tau propagation mechanisms and therapeutic interception points

Which cell types show the most significant expression changes for neurodegenerat

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas

Experiments (0)

Related Papers (0)

Debates (8)

Mechanistic validation of SEA-AD differential expression hypotheses: Complement

Mechanistic validation of SEA-AD differential expression hypotheses: Complement

Do these mechanistic hypotheses explain layer-specific synaptic vulnerability in

Do these mechanistic hypotheses from the SEA-AD Atlas bundle explain layer-speci

Investigate prion-like spreading of tau pathology through connected brain region

Tau propagation mechanisms and therapeutic interception points

The debate mentioned gene expression profiling but did not specify which neural

Cell-type specific expression patterns of neurodegeneration genes in SEA-AD

Related Research