protein

SLC17A7

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SLC17A7: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

351Connections

2Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

Page for slc17a7 Protein

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🔬 Protein Info

Gene Symbol	SLC17A7
Full Name	Solute Carrier Family 17 Member 7
Chromosome	19q13.33
Protein Type	Transporter
Target Class	Transporter
Function	Expression restoration — upregulating SLC17A7 transcription or stabilizing VGLUT1 protein to preserve excitatory synaptic function
Mechanism of Action	Expression restoration — upregulating SLC17A7 transcription or stabilizing VGLUT1 protein to preserve excitatory synaptic function
Primary Expression	thalamocortical neurons and subpopulations of cortical and hippocampal neurons
Druggability	Medium (0.53)
Clinical Stage	Phase III
Molecular Weight	65 kDa
Pathways	Amyloid, Apoptosis, Excitability, Excitatory synaptic transmission, Insulin signalling
UniProt ID	Q9P2U8
NCBI Gene ID	8703
Ensembl ID	ENSG00000177508
GeneCards	SLC17A7
Human Protein Atlas	SLC17A7
Associated Diseases	Als, alzheimer_s_disease, Alzheimer's disease, Cancer
Known Drugs/Compounds	Riluzole, Troriluzole, Chicago Sky Blue 6B
Interactions	ADCYAP1R1, Albumin, ATP1A2, CANCER, CDK5R2, CLDN4
SciDEX Target	View Target Profile (8 clinical trials)
SciDEX Hypotheses	Excitatory Neuron Vulnerability via SLC17A7 Downre Layer V excitatory neurons show selectively enhanc
KG Connections	351 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: SLC17A7 — AlphaFold Q9P2U8 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

slc17a7 Gene

gene · 701 words

→

VGLUT1 Protein (SLC17A7)

protein · 1652 words

→

Pathway Diagram

graph TD
    SLC17A7("SLC17A7")
    h_seaad_7f15df4c["h-seaad-7f15df4c"]
    h_seaad_7f15df4c -->|"targets_gene"| SLC17A7
    Alzheimer_s_Disease{"Alzheimer's Disease"}
    SLC17A7 -->|"associated_with"| Alzheimer_s_Disease
    Glutamatergic_Transmission_Synaptic_Function(["Glutamatergic Transmission / Synaptic Function"])
    SLC17A7 -->|"participates_in"| Glutamatergic_Transmission_Synaptic_Function
    Excitatory_synaptic_transmission(["Excitatory synaptic transmission"])
    SLC17A7 -->|"involved_in"| Excitatory_synaptic_transmission
    Hippocampus["Hippocampus"]
    SLC17A7 -->|"expressed_in"| Hippocampus
    Subiculum["Subiculum"]
    SLC17A7 -->|"expressed_in"| Subiculum
    Alzheimer_s_disease{"Alzheimer's disease"}
    SLC17A7 -->|"associated_with"| Alzheimer_s_disease
    Excitatory_postsynaptic_injury(["Excitatory postsynaptic injury"])
    SLC17A7 -->|"implicated_in"| Excitatory_postsynaptic_injury
    neurodegeneration["neurodegeneration"]
    SLC17A7 -->|"studied_in"| neurodegeneration
    Glutamate["Glutamate"]
    SLC17A7 -->|"involved_in"| Glutamate
    Cognitive_function(["Cognitive function"])
    SLC17A7 -->|"associated_with"| Cognitive_function
    SLC17A7 -->|"biomarker_for"| Alzheimer_s_disease
    Insulin_signalling(["Insulin signalling"])
    SLC17A7 -->|"regulates"| Insulin_signalling
    L_glutamate["L-glutamate"]
    SLC17A7 -->|"binds_to"| L_glutamate
    Synaptic_vesicles["Synaptic vesicles"]
    SLC17A7 -->|"expressed_in"| Synaptic_vesicles

Outgoing (209)

Target	Relation	Type	Str
HIPPOCAMPUS	enriched_in	brain_region	0.95
LAYER_3_NEURONS	expressed_in	cell_type	0.90
LTP	required_for	process	0.90
SPATIAL_MEMORY	required_for	phenotype	0.85
ALZHEIMER'S DISEASE	downregulated_in	disease	0.85
LAYER_5_NEURONS	expressed_in	cell_type	0.85
Glutamate Release	mediates	process	0.85
COGNITIVE_DECLINE	loss_correlates_with	phenotype	0.85
SYNAPTOPHYSIN	co-expressed_with	protein	0.85
NMDA_RECEPTOR	functionally_coupled_to	receptor	0.80
PSD95	functionally_coupled_to	protein	0.80
AMYLOID-BETA	suppressed_by	protein	0.80
C1QA	synapse_loss_linked_to	gene	0.75
LEVETIRACETAM	potential_therapeutic_target	drug	0.70
autophagy pathway	participates_in	pathway	0.70
Dementia	expressed_in	disease	0.65
Alzheimer	expressed_in	disease	0.65
Encephalitis	therapeutic_target	disease	0.65
Cancer	associated_with	disease	0.65
Cancer	biomarker_for	disease	0.65
Neurodegeneration	causes	disease	0.65
Als	associated_with	disease	0.65
Alzheimer	regulates	disease	0.65
Schizophrenia	expressed_in	disease	0.65
excitatory neurons	expressed_in	cell_type	0.65
Inflammation	associated_with	disease	0.65
Dementia	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Pyroptosis	therapeutic_target	disease	0.65
Necroptosis	therapeutic_target	disease	0.65
neurons	expressed_in	cell_type	0.65
ALS	associated_with	disease	0.65
Neurodegeneration	encodes	disease	0.65
Tumor	associated_with	disease	0.65
Neurodegeneration	expressed_in	disease	0.65
Glutamatergic Transmission / Synaptic Function	participates_in	pathway	0.64
Alzheimer's Disease	associated_with	disease	0.64
L-glutamate	binds_to	drug	0.60
Synaptic vesicles	expressed_in	cell_type	0.60
Excitability	regulates	pathway	0.60
Epileptogenesis	implicated_in	disease	0.60
SLC17A6	biomarker_for	gene	0.60
SLC12A5	biomarker_for	gene	0.60
SYN2	biomarker_for	gene	0.60
GAD1	biomarker_for	gene	0.60
SYP	biomarker_for	gene	0.60
SLC32A1	biomarker_for	gene	0.60
GRIN2A	biomarker_for	gene	0.60
PVALB	biomarker_for	gene	0.60
SNAP25	biomarker_for	gene	0.60

Incoming (142)

Source	Relation	Type	Str
VGLUT1	encoded_by	protein	0.99
h-seaad-7f15df4c	targets	hypothesis	0.90
PAL	downregulates	drug	0.90
h_seaad_003	targets_gene	hypothesis	0.90
C1QA	loss_linked_to	gene	0.75
GRIN2A	biomarker_for	gene	0.60
GAD1	biomarker_for	gene	0.60
NEURON	activates	gene	0.60
GRIN2B	expressed_in	gene	0.60
GRID1	expressed_in	gene	0.60
SCN4B	associated_with	gene	0.60
AKT	expressed_in	gene	0.60
RAB11	expressed_in	gene	0.60
CACNA1G	biomarker_for	gene	0.60
BDNF	expressed_in	gene	0.60
TRKB	expressed_in	gene	0.60
SLC32A1	associated_with	gene	0.60
SST	associated_with	gene	0.60
SCN2B	associated_with	gene	0.60
STAT1	associated_with	gene	0.60
ISG15	associated_with	gene	0.60
SCN8A	associated_with	gene	0.60
FGF13	associated_with	gene	0.60
NTRK2	associated_with	gene	0.60
GENES	biomarker_for	gene	0.60
GENES	associated_with	gene	0.60
INS	associated_with	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
ENDOSOMES	expressed_in	gene	0.60
APOPTOSIS	regulates	gene	0.60
NPY	interacts_with	gene	0.60
NEURODEGENERATION	expressed_in	gene	0.60
GENES	expressed_in	gene	0.60
PRESENILIN	regulates	gene	0.60
ALZHEIMER	regulates	gene	0.60
AMYLOID	regulates	gene	0.60
CLDN4	associated_with	gene	0.60
SYP	biomarker_for	gene	0.60
CALB1	biomarker_for	gene	0.60
RAB7	expressed_in	gene	0.60
GRIA2	associated_with	gene	0.60
RAB5	expressed_in	gene	0.60
AKT	associated_with	gene	0.60
BDNF	associated_with	gene	0.60
GRIN2B	co_discussed	gene	0.60
APP	associated_with	gene	0.60
BACE1	associated_with	gene	0.60
MAPT	associated_with	gene	0.60
PYROPTOSIS	therapeutic_target	gene	0.60
NEURODEGENERATION	causes	gene	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Excitatory Neuron Vulnerability via SLC17A7 Downregulation	0.675	Alzheimer's Disease	SEA-AD Gene Expression Profiling — Allen
Layer V excitatory neurons show selectively enhanced vulnera	0.632	Alzheimer's disease	SEA-AD Single-Cell Analysis: Cell-Type V

Mentioning Analyses (1)

Scientific analyses that reference this entity

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas

neurodegeneration | 2026-04-02 | 5 hypotheses Top: 0.761

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (8)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Social Processing in the Amygdala: Single-Nucleus RNA-Sequencing Reveals Distinc [PMID:41727617]	Dwortz MF, Hofmann HA, Curley JP	Res Sq	2026
Sevoflurane aggravates hypoxic-ischemic encephalopathy in preterm neonates via V [PMID:40602692]	Qin M, Shi D, Song X, Zhang R, Feng Z, L	Brain research bulletin	2025
Audiogenic kindling activates glutamatergic system in the hippocampus of rats wi [PMID:38325559]	Aleksandrova EP, Ivlev AP, Kulikov AA, N	Brain research	2024
Alzheimer's Disease-associated Region-specific Decrease of Vesicular Glutamate T [PMID:38552733]	Wood OWG, Walby J, Yeung JH, Ke S, Palpa	Neuroscience	2024
Single-cell atlas reveals correlates of high cognitive function, dementia, and r [PMID:37774677]	Mathys H, Peng Z, Boix CA, Victor MB, Le	Cell	2023
Neurovascular dysfunction in GRN-associated frontotemporal dementia identified b [PMID:35879464]	Gerrits E, Giannini LAA, Brouwer N, Melh	Nature neuroscience	2022
Deciphering molecular interactions by proximity labeling. [PMID:33432242]	Qin W, Cho KF, Cavanagh PE, Ting AY	Nature methods	2021
Bolstering human rabies surveillance in Africa is crucial to eliminating canine- [PMID:30188896]	Anaïs Broban; Mathurin C Tejiokem; Issak	PLoS neglected tropical diseas	2018

Debates (1)

Multi-agent debates referencing this entity

Cell-type specific expression patterns of neurodegeneration genes in SEA-AD

closed · Rounds: 3 · Score: 0.68 · 2026-04-02

Related Research

Hypotheses and analyses mentioning SLC17A7 in their description or question text

No additional research found