concept

GLUTAMATE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GLUTAMATE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

638Connections

3Hypotheses

0Analyses

50Outgoing

50Incoming

1Experiments

0Debates

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💡 Concept Info

Name	GLUTAMATE
Key Genes/Proteins	ABCA7, ADRA2B, AKT, ALZHEIMER, AMPA RECEPTOR, AMPK
Related Diseases	acetylcholine, ACETYLCHOLINE, ALS, Alzheimer'S Disease, ALZHEIMER'S DISEASE
Related Pathways	AMPK SIGNALING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Glutamate Excitotoxicity Pathway in Neurodegeneration

mechanism · 2827 words

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Pathway Diagram

graph TD
    GLUTAMATE["GLUTAMATE"]
    GLUTAMATE -->|"causes"| Excitotoxicity["Excitotoxicity"]
    GLUTAMATE -->|"inhibits"| SYSTEM_XC_["SYSTEM XC-"]
    GLUTAMATE -->|"causes"| EXCITOTOXICITY["EXCITOTOXICITY"]
    GLUTAMATE -->|"causes"| excitotoxicity["excitotoxicity"]
    GLUTAMATE -->|"causes"| motor_neuron["motor neuron"]
    GLUTAMATE -->|"activates"| neurodegeneration["neurodegeneration"]
    GLUTAMATE -->|"interacts"| NF_KB["NF-KB"]
    GLUTAMATE -->|"inhibits"| AXONS["AXONS"]
    FERROPTOSIS["FERROPTOSIS"] -->|"inhibits"| GLUTAMATE
    MACROPHAGES["MACROPHAGES"] -->|"activates"| GLUTAMATE
    MITOPHAGY["MITOPHAGY"] -->|"activates"| GLUTAMATE
    PARKIN["PARKIN"] -->|"activates"| GLUTAMATE
    PINK1["PINK1"] -->|"activates"| GLUTAMATE
    PTEN["PTEN"] -->|"activates"| GLUTAMATE
    UBIQUITIN["UBIQUITIN"] -->|"activates"| GLUTAMATE
    NEUROINFLAMMATION["NEUROINFLAMMATION"] -->|"activates"| GLUTAMATE
    NEURODEGENERATION["NEURODEGENERATION"] -->|"inhibits"| GLUTAMATE

Outgoing (195)

Target	Relation	Type	Str
Excitotoxicity	causes	mechanism	0.90
ARHGEF7	activates	protein	0.87
SYSTEM XC-	inhibits	protein	0.85
SRC	activates	entity	0.85
Muscle Spindles	activates	structure	0.85
NFKB	activates	protein	0.80
Ferroptosis	associated_with	process	0.80
PVNCaMKII	targets	cell_type	0.80
Axonal Integrity	inhibits	process	0.80
Dementia	associated_with	disease	0.80
APOPTOSIS	associated_with	process	0.80
ASTROCYTES	expressed_in	cell_type	0.80
Axonal Integrity	modulates	phenotype	0.80
Amyotrophic Lateral Sclerosis	contributes_to	disease	0.75
EXCITOTOXICITY	causes	phenotype	0.72
LDHA	causes	gene	0.70
AMYLOID	inhibits	protein	0.70
PRION	activates	protein	0.70
GLUTAMATE EXCITOTOXICITY	causes	phenotype	0.70
excitotoxicity	causes	process	0.70
TAU	phosphorylates	protein	0.70
GLUTAMATE EXCITOTOXICITY	inhibits	phenotype	0.70
motor neuron	activates	cell_type	0.70
NEURONS	stabilizes	cell_type	0.70
motor neuron	causes	cell_type	0.70
neurodegeneration	activates	disease	0.70
NF-KB	interacts_with	protein	0.70
VASCULAR DEMENTIA	causes	disease	0.65
PARKINSON'S DISEASE	interacts_with	disease	0.65
HUNTINGTON'S DISEASE	inhibits	disease	0.65
HIPPOCAMPUS	regulates	brain_region	0.65
ACETYLCHOLINE	biomarker_for	phenotype	0.65
NEURONS	causes	cell_type	0.65
STROKE	produces	disease	0.65
WHITE MATTER	targets	brain_region	0.65
CHOLESTEROL	targets	phenotype	0.65
FERROPTOSIS	causes	phenotype	0.65
WHITE MATTER	produces	brain_region	0.65
WHITE MATTER	transports	brain_region	0.65
GFAP	transports	gene	0.65
PURKINJE CELLS	regulates	cell_type	0.65
ATG5	inhibits	gene	0.65
NUCLEUS ACCUMBENS	interacts_with	brain_region	0.65
CHOLESTEROL	activates	phenotype	0.65
LAMP1	activates	gene	0.65
ATG5	activates	gene	0.65
PCSK9	targets	gene	0.65
GLAUCOMA	activates	disease	0.65
NLRP3 INFLAMMASOME	activates	pathway	0.65
SYNAPTIC PLASTICITY	regulates	phenotype	0.65

Incoming (443)

Source	Relation	Type	Str
AMYLOID	associated_with	protein	1.00
TAU	associated_with	protein	1.00
ALZHEIMER'S DISEASE	associated_with	disease	1.00
ASTROCYTES	associated_with	cell_type	1.00
ALS	associated_with	disease	0.98
EAAT2	transports	protein	0.95
EAAT1	transports	protein	0.95
Gap Junctional Intercellular Communication	transports	pathway	0.90
GJA1	promotes	protein	0.90
APOE	associated_with	gene	0.82
NF-KB	associated_with	protein	0.82
APP	associated_with	gene	0.82
ASTROCYTES	activates	cell_type	0.80
Macrophages	product_of	cell_type	0.80
CASP3	associated_with	gene	0.74
PARKINSON'S DISEASE	associated_with	disease	0.74
TARDBP	associated_with	gene	0.74
SOD1	associated_with	gene	0.74
AKT	associated_with	gene	0.74
ASTROCYTES	protects_against	cell_type	0.70
CYTOKINES	regulates	phenotype	0.70
AMYLOID	causes	protein	0.70
NEURODEGENERATION	treats	phenotype	0.70
APOE	regulates	gene	0.70
APOE	causes	gene	0.70
MICROGLIA	associated_with	cell_type	0.66
ALS	causes	disease	0.66
TNF	associated_with	gene	0.66
BDNF	associated_with	gene	0.66
UBIQUITIN	associated_with	protein	0.66
LRRK2	treats	gene	0.65
DEPRESSION	inhibits	disease	0.65
HIPPOCAMPUS	causes	brain_region	0.65
SLC7A11	regulates	gene	0.65
STING	causes	gene	0.65
TAU	regulates	protein	0.65
KETAMINE	activates	drug	0.65
KDM6B	regulates	gene	0.65
NEUROINFLAMMATION	inhibits	phenotype	0.65
AXONAL DEGENERATION	activates	phenotype	0.65
GLIAL FIBRILLARY ACIDIC PROTEIN	causes	biomarker	0.65
ROS	protects_against	phenotype	0.65
GFAP	causes	gene	0.65
CELL DEATH	causes	phenotype	0.65
LIPID PEROXIDATION	inhibits	phenotype	0.65
ALZHEIMER'S DISEASE	treats	disease	0.65
ABCA7	exacerbates	gene	0.65
BDNF	causes	gene	0.65
BDNF	protects_against	gene	0.65
BIN1	causes	gene	0.65

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
AQP4-Dependent Astrocyte Swelling Exacerbates Excitotoxic Ne	0.670	neurodegeneration	What are the specific molecular mechanis
Microglial xCT/SLC7A11 Selective Inhibition to Reduce Non-Ce	0.620	-	Ferroptosis in ALS and motor neuron dise
Reactive astrocyte glutamate-handling failure sustains dendr	0.490	neurodegeneration	Does tau dendritic missorting persist in

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Gandouling protection against brain injury in Wilson's disease via SIR	validation	Hepatolenticular degeneration	0.900	0.00	TX mice (Wilson's disease mode	proposed	N/A

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning GLUTAMATE in their description or question text

No additional research found