Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about H3K27me3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| h-e9c2d00456 | targeted_by | hypothesis | 1.00 |
| h-25cfa8f46c | targeted_by | hypothesis | 1.00 |
| Cancer Gene Expression | biomarker_for | process | 0.90 |
| MMP10 | regulates | gene | 0.85 |
| Cancer Gene Expression | associated_with | process | 0.85 |
| Cancer | associated_with | disease | 0.85 |
| Cancer | biomarker_for | disease | 0.80 |
| CLDN5 | inhibits | gene | 0.70 |
| neuronal function genes | represses | gene | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| h-25cfa8f46c | targets | hypothesis | 1.00 |
| h-e9c2d00456 | targets | hypothesis | 1.00 |
| Histone Methylation-Targeted Therapy | targets | drug | 0.90 |
| Histone Methylation-Targeted Therapy | targets | drug | 0.90 |
| EZH2 | deposits | enzyme | 0.90 |
| EZH2 | catalyzes | protein | 0.88 |
| KDM6A | demethylates | gene | 0.80 |
| EZH2 | regulates | gene | 0.70 |
| STAT3 | regulates | protein | 0.70 |
| JMJD3 | regulates | protein | 0.64 |
| EZH2 | catalytic_activity | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| KDM6A-Mediated H3K27me3 Rejuvenation | 0.653 | neurodegeneration | Epigenetic clocks and biological aging i |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-18 | 7 hypotheses Top: 0.620
neurodegeneration | 2026-04-18 | 0 hypotheses
neurodegeneration | 2026-04-16 | 7 hypotheses Top: 0.550
neurodegeneration | 2026-04-10 | 0 hypotheses
neurodegeneration | 2026-04-01 | 6 hypotheses Top: 0.710
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Proposed experiment from debate on Epigenetic clocks and biological ag | falsification | Neurodegeneration | 0.400 | 0.50 | mouse | proposed | $450,000 |
| Cognitive Reserve Mechanisms in Alzheimer's Disease — Molecular Basis | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $6,550,000 |
| DNA Damage Repair Deficiency Validation Study in Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $7,500,000 |
| Epigenetic Clocks in Neurodegeneration — Causal Drivers or Passive Mar | validation | Neurodegeneration | 0.400 | 0.50 | human | proposed | $3,000,000 |
| Epigenetic Dysregulation in Huntington's Disease — Therapeutic Targeti | validation | Neurodegeneration | 0.400 | 0.50 | human | proposed | $3,000,000 |
| LRRK2/GBA Mutation Carrier Resilience — Why Some Carriers Never Develo | validation | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $2,730,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| De novo germline and postzygotic mutations in AKT3, PIK3R2 and PIK3CA cause a sp [PMID:22729224] | ["Rivi\u00e8re J", "Mirzaa G", "O'Roak B | Nature Genetics | 2012 | 748 |
| High-Resolution Differentiation of Enteric Bacteria in Premature Infant Fecal Mi [PMID:33593974] | Graf J, Ledala N, Caimano MJ, Jackson E, | mBio | 2021 | 1 |
| Development of a deep learning-based software for calculating cleansing score in [PMID:33627678] | Nam JH, Hwang Y, Oh DJ, Park J, Kim KB, | Sci Rep | 2021 | 1 |
| Bacterial siderophores in community and host interactions. [PMID:31748738] | Kramer J, Özkaya Ö, Kümmerli R | Nat Rev Microbiol | 2020 | 1 |
| SARS-CoV-2 infection induces long-lived bone marrow plasma cells in humans. [PMID:33398264] | Turner JS, Kim W, Kalaidina E, Goss CW, | Res Sq | 2020 | 1 |
| ApoE-associated modulation of neuroprotection from Aβ-mediated neurodegeneration [PMID:30683808] | Griffin EF, Scopel SE, Stephen CA, Holzh | Dis Model Mech | 2019 | 1 |
| Endodermal Maternal Transcription Factors Establish Super-Enhancers during Zygot [PMID:31167141] | Paraiso KD, Blitz IL, Coley M, Cheung J, | Cell Rep | 2019 | 1 |
| Modification of ASC1 by UFM1 is crucial for ERα transactivation and breast cance [PMID:25219498] | Yoo HM, Kang SH, Kim JY, Lee JE, Seong M | Mol Cell | 2014 | 1 |
| Foxh1 is a locus-specific PRC2 recruiter governing germ layer silencing. [PMID:41040321] | ["Cho J", "Hendrickson C", "Mar N", "Bli | bioRxiv : the preprint server | 2025 | 0 |
| Epigenetic regulation of bladder cancer in the context of aging. [PMID:40918525] | ["Liu X", "Ding G", "Liu Y", "Yan X", "Z | Frontiers in pharmacology | 2025 | 0 |
| Loss of Kmt2c or Kmt2d drives brain metastasis via KDM6A-dependent upregulation [PMID:38926506] | Seehawer M, Li Z, Nishida J, Foidart P, | Nature cell biology | 2024 | 0 |
| Epigenetic regulation of CD38/CD48 by KDM6A mediates NK cell response in multipl [PMID:38355622] | Liu J, Xing L, Li J, Wen K, Liu N, Liu Y | Nature communications | 2024 | 0 |
| Wnt-deficient and hypoxic environment orchestrates squamous reprogramming of hum [PMID:39232216] | Tamagawa H, Fujii M, Togasaki K, Seino T | Nature cell biology | 2024 | 0 |
| KDM6A epigenetically regulates subtype plasticity in small cell lung cancer. [PMID:37591951] | Duplaquet L, Li Y, Booker MA, Xie Y, Ols | Nature cell biology | 2023 | 0 |
| H3K36 dimethylation shapes the epigenetic interaction landscape by directing rep [PMID:35396277] | ["Chen H", "Hu B", "Horth C", "Bareke E" | Genome research | 2022 | 0 |
| An intramembrane chaperone complex facilitates membrane protein biogenesis. [PMID:32814900] | ["Chitwood PJ", "Hegde RS"] | Nature | 2020 | 0 |
| In vitro anti-HIV-1 activity of the bioactive compound extracted and purified fr [PMID:31434919] | ["Sanniyasi E", "Venkatasubramanian G", | Scientific reports | 2019 | 0 |
| Targeting Excessive EZH1 and EZH2 Activities for Abnormal Histone Methylation an [PMID:31747604] | Yamagishi M, Hori M, Fujikawa D, Ohsugi | Cell reports | 2019 | 0 |
| Benefit of Adjuvant Chemoradiotherapy in Resected Gallbladder Carcinoma. [PMID:31409811] | ["Kim T", "Woo S", "Lee W", "Oh E", "You | Scientific reports | 2019 | 0 |
| Opportunities and obstacles for deep learning in biology and medicine. [PMID:29618526] | ["Ching T", "Himmelstein D", "Beaulieu-J | Journal of the Royal Society, | 2018 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 0 · Score: 0.50 · 2026-04-21
closed · Rounds: 0 · Score: 0.56 · 2026-04-21
closed · Rounds: 4 · Score: 1.00 · 2026-04-20
closed · Rounds: 4 · Score: 1.00 · 2026-04-20
closed · Rounds: 4 · Score: 0.50 · 2026-04-18
closed · Rounds: 4 · Score: 0.93 · 2026-04-06
Hypotheses and analyses mentioning H3K27me3 in their description or question text
No additional research found