gene 1,775 words KG: JAG1
Contents

JAG1 — Jagged 1

🧬 Gene Info
Gene SymbolJAG1
Full NameJagged 1
Chromosome20p12.2
Functionis a critical member of the Notch ligand family that plays essential roles in cell fate determination, embryonic development, tissue homeostasis, and increasingly recognized functions in neurodegen...
Primary ExpressionCerebral cortex, Cochlea, Liver, Heart
Molecular Weight134 kDa
Amino Acids218 aa
PathwaysNotch, NOTCH, Notch signaling
UniProt IDP78504
NCBI Gene ID1950
Ensembl IDENSG00000101384
OMIM184756
GeneCardsJAG1
Human Protein AtlasJAG1
Associated DiseasesALS, neurodegeneration
InteractionsAPOPTOSIS, AUTOPHAGY, NOTCH, NOTCH1, Rb, RNA
KG Connections180 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (1)

Epigenetic Memory Reprogramming for Alzheimer's Disease
Score: 0.61

Related Analyses (2)

Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
CRISPR-based therapeutic approaches for neurodegenerative di
neurodegeneration · archived

See Also (15)

Apoptosis in Neurodegeneration
entity · KG edge: inhibits
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: inhibits
ABCB1 (MDR1) - ATP Binding Cassette Subfamily B Member
gene · KG edge: therapeutic_target
ALDH1A1 Gene
gene · KG edge: therapeutic_target
APC Gene
gene · KG edge: therapeutic_target

Knowledge Graph (12 edges)

BRG1 therapeutic_target JAG1
NRCAM therapeutic_target JAG1
NOTCH2 therapeutic_target JAG1
EP300 therapeutic_target JAG1
CTNNB1 therapeutic_target JAG1
NEUROD1 therapeutic_target JAG1
MYC therapeutic_target JAG1
VEGFA therapeutic_target JAG1
FOXM1 therapeutic_target JAG1
LEF1 therapeutic_target JAG1

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