pathway

NOTCH

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NOTCH: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1670Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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🔀 Pathway Info

Name	NOTCH
Key Genes/Proteins	ACHE, Actin, AD, ADAM10, AGING, AIF1
Related Diseases	Aging, Als, ALS, Alzheimer
Related Pathways	Adaptive Immunity, Akt

Wiki Pages (8)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    NOTCH["NOTCH"] -->|"participates in"| CANCER["CANCER"]
    NOTCH["NOTCH"] -->|"regulates"| CANCER_1["CANCER"]
    NOTCH["NOTCH"] -->|"participates in"| CERVICAL_CANCER["CERVICAL CANCER"]
    NOTCH["NOTCH"] -->|"therapeutic target"| Tumor["Tumor"]
    NOTCH["NOTCH"] -->|"therapeutic target"| Cancer["Cancer"]
    NOTCH["NOTCH"] -->|"therapeutic target"| Cardiovascular["Cardiovascular"]
    ENDOTHELIAL["ENDOTHELIAL"] -.->|"inhibits"| NOTCH["NOTCH"]
    MACROPHAGE["MACROPHAGE"] -.->|"inhibits"| NOTCH["NOTCH"]
    LRP1["LRP1"] -->|"regulates"| NOTCH["NOTCH"]
    DNA_DAMAGE["DNA DAMAGE"] -->|"regulates"| NOTCH["NOTCH"]
    style NOTCH fill:#1b5e20,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (499)

Target	Relation	Type	Str
Progenitor Cell Fate Determination	regulates	process	0.95
Neuronal Subtype Differentiation	involved_in	process	0.90
Notch signaling	participates_in	pathway	0.80
CERVICAL CANCER	participates_in	disease	0.80
CANCER	regulates	disease	0.80
CANCER	participates_in	disease	0.80
VEGF	mediates	gene	0.70
VEGF	expresses	gene	0.70
STING	expresses	gene	0.70
WNT	mediates	gene	0.70
PSEN1	expresses	gene	0.70
PSEN1	degrades	gene	0.70
PSEN1	interacts_with	gene	0.70
SIRT1	activates	gene	0.70
PSEN2	interacts_with	gene	0.70
apoptosis pathway	participates_in	pathway	0.70
Hepatitis	activates	disease	0.65
TUMOR	regulates	disease	0.65
T CELL	causes	cell_type	0.65
Alzheimer	activates	disease	0.65
Carcinoma	interacts_with	disease	0.65
Diabetes	associated_with	disease	0.65
Fibrosis	activates	disease	0.65
Als	inhibits	disease	0.65
Fibrosis	contributes_to	disease	0.65
Hepatitis	interacts_with	disease	0.65
ALS	causes	disease	0.65
Inflammation	activates	disease	0.65
Fibrosis	interacts_with	disease	0.65
T CELLS	causes	cell_type	0.65
Cancer	activates	disease	0.65
Als	interacts_with	disease	0.65
Neuroinflammation	therapeutic_target	disease	0.65
Multiple Sclerosis	therapeutic_target	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
PARKINSON	associated_with	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Als	associated_with	disease	0.65
Neurodegeneration	regulates	disease	0.65
Dementia	regulates	disease	0.65
Als	degrades	disease	0.65
Cancer	associated_with	disease	0.65
Neuroinflammation	regulates	disease	0.65
PARKIN	associated_with	gene	0.65
PARKINSON'S DISEASE	associated_with	disease	0.65
Ms	regulates	disease	0.65
UBIQUITIN	contributes_to	gene	0.65
Inflammation	therapeutic_target	disease	0.65
Metabolic Syndrome	therapeutic_target	disease	0.65
Cancer	regulates	disease	0.65

Incoming (1171)

Source	Relation	Type	Str
CANCER	therapeutic_target	gene	1.00
Als	therapeutic_target	disease	1.00
Cancer	therapeutic_target	disease	1.00
Tumor	therapeutic_target	disease	1.00
Als	regulates	disease	1.00
Inflammation	therapeutic_target	disease	1.00
Inflammation	activates	disease	1.00
SYNCRIP	regulates	gene	0.90
INFLAMMATION	activates	gene	0.90
GENES	associated_with	gene	0.90
Als	activates	disease	0.90
Inflammation	regulates	disease	0.90
GENES	regulates	gene	0.90
CANCER	regulates	gene	0.90
INFLAMMATION	therapeutic_target	gene	0.90
GENES	therapeutic_target	gene	0.90
NOTCH1	inhibits	gene	0.90
Cancer	regulates	disease	0.90
CANCER	associated_with	gene	0.90
ALZHEIMER'S DISEASE	associated_with	disease	0.88
Als	expressed_in	disease	0.80
Leukemia	therapeutic_target	disease	0.80
Cancer	associated_with	disease	0.80
PI3K	regulates	gene	0.80
NF-ΚB	associated_with	gene	0.80
Als	associated_with	disease	0.80
APOPTOSIS	regulates	gene	0.80
MIRNAS	regulates	gene	0.80
AKT	associated_with	gene	0.80
Tumor	inhibits	disease	0.80
NOTCH1	expressed_in	gene	0.80
PI3K	associated_with	gene	0.80
Aging	activates	disease	0.80
ALZHEIMER'S DISEASE	regulates	gene	0.80
ROS	activates	gene	0.80
NEURONS	activates	cell_type	0.70
ENDOTHELIAL	disrupts	cell_type	0.70
CX3CR1	activates	gene	0.70
NEURONS	expresses	cell_type	0.70
BACE1	inhibits	gene	0.70
FOXP3	activates	gene	0.70
AMPK	regulates	gene	0.70
ENDOTHELIAL	expresses	cell_type	0.70
APP	expresses	gene	0.70
CD38	activates	gene	0.70
GFAP	expressed_in	gene	0.70
DRD2	transports	gene	0.70
GABAERGIC	transports	cell_type	0.70
GABRA1	transports	gene	0.70
DRD1	transports	gene	0.70

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NOTCH in their description or question text

No additional research found

NOTCH

Understanding Entity Pages

Wiki Pages (8)

Notch Signaling Pathway in Neurodegeneration

NOTCH2 — Notch Receptor 2

NOTCH2NLC Gene

NOTCH3 Protein

NOTCH3 — Notch Receptor 3