gene

BMP2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BMP2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

124Connections

0Hypotheses

0Analyses

50Outgoing

30Incoming

0Experiments

0Debates

Summary

BMP2 is a gene implicated in neurodegeneration research. Key relationships include: activates, associated with, inhibits. Associated with ALS, Als, Arthritis. Connected to 46 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	BMP2
Full Name	Bone Morphogenetic Protein 2
Chromosome	20q12
Function	encodes a secreted signaling molecule belonging to the TGF-β superfamily.
Amino Acids	396 aa
Exons	3
Pathways	TGF-β
UniProt ID	P12643
NCBI Gene ID	645
Ensembl ID	ENSG00000125845
GeneCards	BMP2
Human Protein Atlas	BMP2
Signal peptide	N-terminal secretion signal
Prodomain	Cleaved to generate active dimer
C-terminal domain	Contains the mature, active dimer
Associated Diseases	ALS, Cancer, Carcinoma, MELANOMA, Ms, Tumor
Interactions	AGING, AKT, AND, ANGPT1, AXL, BMP
KG Connections	124 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: BMP2 — AlphaFold P12643 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

BMP2 — Bone Morphogenetic Protein 2

gene · 1293 words

→

BMP2 Protein

protein · 644 words

→

Pathway Diagram

graph TD
    BMP2["BMP2"]
    Als{"Als"}
    BMP2 -->|"activates"| Als
    Arthritis{"Arthritis"}
    BMP2 -->|"activates"| Arthritis
    Carcinoma{"Carcinoma"}
    BMP2 -->|"associated with"| Carcinoma
    Ms{"Ms"}
    BMP2 -->|"associated with"| Ms
    Cancer{"Cancer"}
    BMP2 -->|"associated with"| Cancer
    Tumor{"Tumor"}
    BMP2 -->|"associated with"| Tumor
    ALS{"ALS"}
    BMP2 -->|"activates"| ALS
    VEGF["VEGF"]
    BMP2 -->|"activates"| VEGF
    FGF2["FGF2"]
    BMP2 -->|"activates"| FGF2
    ANGPT1["ANGPT1"]
    BMP2 -->|"activates"| ANGPT1
    PDGFRB["PDGFRB"]
    BMP2 -->|"activates"| PDGFRB
    VEGFB["VEGFB"]
    BMP2 -->|"activates"| VEGFB
    VEGFB -->|"activates"| BMP2
    VEGF -->|"activates"| BMP2
    FGF2 -->|"activates"| BMP2
    RUNX2["RUNX2"]
    RUNX2 -->|"activates"| BMP2
    PDGFRB -->|"activates"| BMP2
    GENES["GENES"]
    GENES -->|"activates"| BMP2
    ANGPT1 -->|"activates"| BMP2
    TGFBR2["TGFBR2"]
    TGFBR2 -->|"associated with"| BMP2
    BMP4["BMP4"]
    BMP4 -->|"associated with"| BMP2
    MIRNAS["MIRNAS"]
    MIRNAS -->|"associated with"| BMP2
    MYC["MYC"]
    MYC -->|"associated with"| BMP2
    E2F5["E2F5"]
    E2F5 -->|"associated with"| BMP2
    style BMP2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (94)

Target	Relation	Type	Str
Osteogenesis	promotes	process	0.90
Osteogenic Differentiation	promotes	process	0.85
RUNX2	inhibits	gene	0.70
Cardiovascular	inhibits	disease	0.65
ALS	activates	disease	0.65
MELANOMA	causes	disease	0.65
Senescence	activates	disease	0.65
Arthritis	activates	disease	0.65
Tumor	activates	disease	0.65
Aging	activates	disease	0.65
Ms	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Tumor	associated_with	disease	0.65
Carcinoma	associated_with	disease	0.65
Als	activates	disease	0.65
VEGFB	activates	gene	0.60
DLAT	inhibits	gene	0.60
PI3K	activates	gene	0.60
AKT	activates	gene	0.60
EZH2	upregulates	entity	0.60
macrophages	expressed_in	cell_type	0.60
AXL	activates	gene	0.60
EZH2	activates	gene	0.60
Osteoblast	therapeutic_target	cell_type	0.60
PRMT1	expressed_in	gene	0.60
Angiogenesis	activates	pathway	0.60
BRAF	inhibits	entity	0.60
TGF-beta signaling	participates_in	pathway	0.60
neurons	expressed_in	cell_type	0.60
VEGF	activates	gene	0.60
FGF2	activates	gene	0.60
ANGPT1	activates	gene	0.60
PDGFRB	activates	gene	0.60
MITOPHAGY	inhibits	gene	0.60
NF-ΚB	inhibits	gene	0.60
Mitophagy	inhibits	pathway	0.60
Raf	inhibits	protein	0.60
Nf-Κb	inhibits	pathway	0.60
BMPR1A	activates	gene	0.60
RUNX2	activates	gene	0.60
Pdgf	activates	protein	0.60
Fgf	activates	protein	0.60
Ras	activates	protein	0.60
stem cells	expressed_in	cell_type	0.60
AND	inhibits	gene	0.60
EZH2	regulates	gene	0.60
CD31	activates	gene	0.60
ROS	activates	gene	0.60
MEK	inhibits	gene	0.60
TGFB2	associated_with	gene	0.60

Incoming (30)

Source	Relation	Type	Str
Irisin	upregulates	protein	0.90
H3K9la	associated_with	phenotype	0.85
BMPR1B	participates_in	gene	0.80
AGING	regulates	phenotype	0.65
VEGFB	activates	gene	0.60
BMP	activates	gene	0.60
FGF2	activates	gene	0.60
PDGFRB	activates	gene	0.60
ANGPT1	activates	gene	0.60
VEGF	activates	gene	0.60
AND	inhibits	gene	0.60
TGFBR2	associated_with	gene	0.60
BMP4	associated_with	gene	0.60
MYC	associated_with	gene	0.60
E2F5	associated_with	gene	0.60
CDKN2B	associated_with	gene	0.60
TGFBR1	associated_with	gene	0.60
AGING	activates	gene	0.60
MEK	inhibits	gene	0.60
RUNX2	activates	gene	0.60
GENES	activates	gene	0.60
MIRNAS	associated_with	gene	0.60
CANCER	associated_with	gene	0.60
AXL	activates	gene	0.60
JAG1	therapeutic_target	gene	0.60
ROS	activates	gene	0.60
EZH2	activates	gene	0.50
BRAF	inhibits	gene	0.50
AXL	co_expressed_with	gene	0.50
MELANOMA	associated_with	disease	0.45

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning BMP2 in their description or question text

No additional research found