gene 753 words KG: GAPDH
Contents

GAPDH Gene

🧬 Gene Info
Gene SymbolGAPDH
Full NameGlyceraldehyde-3-Phosphate Dehydrogenase
Chromosome12p13.31
Protein TypeEnzyme
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight37 kDa
PathwaysAkt, Apoptosis, Autophagy, Cell Cycle, Chaperone
UniProt IDP04406
NCBI Gene ID2597
Ensembl IDENSG00000111640
OMIM138400
GeneCardsGAPDH
Human Protein AtlasGAPDH
Associated DiseasesAging, Als, Alzheimer, Alzheimer's disease, Amyotrophic Lateral Sclerosis, Ataxia
Known Drugs/Compounds5-HT, dimethyl fumarate, levodopa, rapamycin, RAPAMYCIN, Vitamin C
InteractionsABP, ACAT1, ACTB, ACTG1, AGING, AIF1
KG Connections1395 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (30)

CYP46A1 Overexpression Gene Therapy
Score: 0.92
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.91
Transcriptional Autophagy-Lysosome Coupling
Score: 0.88
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78

Related Analyses (14)

Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived

Related Experiments (2)

DNA Damage Repair Deficiency Validation Study in Parkinson's
clinical · proposed · Score: 0.40
FXTAS Phenotypic Penetrance: Why Only 40% of FMR1 Premutatio
validation · proposed · Score: 0.40

See Also (5)

ACTB Gene
gene · KG edge: associated_with
ACTG1 Gene
gene · KG edge: interacts_with
AIF1 Gene
gene · KG edge: associated_with
AKT1 Gene
gene · KG edge: activates
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates

Knowledge Graph (12 edges)

STIP1 associated_with GAPDH
LGALS3 associated_with GAPDH
HSPA8 associated_with GAPDH
MCOLN1 associated_with GAPDH
SQSTM1 associated_with GAPDH
SOD1 associated_with GAPDH
BCL2 associated_with GAPDH
CTSB associated_with GAPDH
TPP1 associated_with GAPDH
GLA associated_with GAPDH

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