| Gene Symbol | GAPDH |
| Full Name | Glyceraldehyde-3-Phosphate Dehydrogenase |
| Chromosome | 12p13.31 |
| Protein Type | Enzyme |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Molecular Weight | 37 kDa |
| Pathways | Akt, Apoptosis, Autophagy, Cell Cycle, Chaperone |
| UniProt ID | P04406 |
| NCBI Gene ID | 2597 |
| Ensembl ID | ENSG00000111640 |
| OMIM | 138400 |
| GeneCards | GAPDH |
| Human Protein Atlas | GAPDH |
| DNA repair | Binds single-strand breaks and abasic sites; stimulates base excision repair (BER) through uracil-DNA glycosylase activation. |
| mRNA regulation | Binds AU-rich elements in the 3′-UTR of transcripts encoding BDNF, APP, and inflammatory cytokines, modulating their stability and translation. |
| Associated Diseases | Aging, Als, Alzheimer, Alzheimer's disease, Amyotrophic Lateral Sclerosis, Ataxia |
| Known Drugs/Compounds | 5-HT, dimethyl fumarate, levodopa, rapamycin, RAPAMYCIN, Vitamin C |
| Interactions | ABP, ACAT1, ACTB, ACTG1, AGING, AIF1 |
| KG Connections | 1389 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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